The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Retrotransposition‐Competent Human LINE‐1 Induces Apoptosis in Cancer Cells With Intact p53
Abstract
Retrotransposition of human LINE‐1 (L1) element, a major representative non‐LTR retrotransposon in the human genome, is known to be a source of insertional mutagenesis. However, nothing is known about effects of L1 retrotransposition on cell growth and differentiation. To investigate the potential for such biological effects and the impact that human L1 retrotransposition has upon cancer cell growth, we examined a panel of human L1 transformed cell lines following a complete retrotransposition process. The results demonstrated that transposition of L1 leads to the activation of the p53‐mediated apoptotic pathway in human cancer cells that possess a wild‐type p53. In addition, we found that inactivation of p53 in cells, where L1 was undergoing retrotransposition, inhibited the induction of apoptosis. This suggests an association between active retrotransposition and a competent p53 response in which induction of apoptosis is a major outcome. These data are consistent with a model in which human retrotransposition is sensed by the cell as a “genetic damaging event” and that massive retrotransposition triggers signaling pathways resulting in apoptosis.
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“When p53 is absent, cells overexpressing synthetic retrotransposon genes are able to avoid apoptosis.82”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [82]
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Cites
Human L1 element target‐primed reverse transcription in vitro
Cost, G. J., Feng, Q., Jacquier, A., & Boeke, J. D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf592 · Cited by 519
Asymmetric methylation in the hypermethylated CpG promoter region of the human L1 retrotransposon
Woodcock, D. M., Lawler, C. B., Linsenmeyer, M. E., Doherty, J. P., & Warren, W. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7810 · Cited by 168
Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks
Gasior, S. L., Wakeman, T. P., Xu, B., & Deininger, P. L. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.01.089 · Cited by 519
Restricting retrotransposons: a review
Goodier, J. L. (2016) · Mobile DNA · doi:10.1186/s13100-016-0070-z · Cited by 436
Coufal, N. G., Garcia-Perez, J. L., Peng, G. E., Marchetto, M. C. N., Muotri, A. R., Mu, Y., Carson, C. T., Macia, A., Moran, J. V., & Gage, F. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100273108 · Cited by 229
Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells
Belgnaoui, S. M., Gosden, R. G., Semmes, O. J., & Haoudi, A. (2006) · Cancer Cell International · doi:10.1186/1475-2867-6-13 · Cited by 219
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Metadata
- Authors
- Haoudi, A., Semmes, O. J., Mason, J. M., & Cannon, R. E.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2004-01
- Volume
- 2004
- Issue
- 4
- Pages
- 185-194
- ISSN
- 2314-6133
- 2314-6141
- Cited by
- 50
- References
- 2
- Language
- en
- Funders
- Fogarty International Center (HHS CA76595)
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- Haoudi, A., Semmes, O. J., Mason, J. M., & Cannon, R. E. (2004). Retrotransposition‐Competent Human LINE‐1 Induces Apoptosis in Cancer Cells With Intact p53. BioMed Research International. https://doi.org/10.1155/s1110724304403131
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