The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Role of Carbonic Anhydrase IX in Human Tumor Cell Growth, Survival, and Invasion
Open accessAbstract
Carbonic anhydrase IX (CAIX) is a membrane-associated carbonic anhydrase (CA), strongly induced by hypoxia. CAIX is overexpressed in a variety of tumor types and associated with increased metastasis and poor prognosis. An inhibitor of CAs, acetazolamide has been reported to inhibit invasion. We used RNA interference (RNAi) to examine the function of CAIX in MDA468 and MDA231 breast carcinoma cells, which express high levels of CAIX under hypoxia. Hypoxia-induced CA activity was completely blocked by specific RNAi (P < 0.01). RNAi-treated cells showed growth delay in dense monolayer culture and a 50% reduction in clonogenic survival under hypoxia. In the MDA468 cells, there was no effect of RNAi treatment on invasion. In a cell line that did not induce CAIX under hypoxia, RT112, we found no effect on the ability of cells transfected with CAIX to invade or migrate. Thus, CAIX plays an important role in the growth and survival of tumor cells under normoxia and hypoxia, making it a potential target for cancer therapy, but is not involved in invasion.
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Cites
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
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Self-citationELECTROMETRIC AND COLORIMETRIC DETERMINATION OF CARBONIC ANHYDRASE
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Acidic pH enhances the invasive behavior of human melanoma cells
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Cited by
Hypoxia in cancer: significance and impact on clinical outcome
Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
Chiche, J., Brahimi‐Horn, M. C., & Pouysségur, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00994.x · Cited by 667
Disrupting proton dynamics and energy metabolism for cancer therapy
Parks, S. K., Chiche, J., & Pouysségur, J. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3579 · Cited by 607
Regulation of tumor pH and the role of carbonic anhydrase 9
Swietach, P., Vaughan-Jones, R. D., & Harris, A. L. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9064-0 · Cited by 539
Self-citationRoles of p53, MYC and HIF-1 in regulating glycolysis–the seventh hallmark of cancer
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Metadata
- Authors
- Robertson, N., Potter, C., & Harris, A. L.
- Venue
- Cancer Research
- Published
- 2004-09-01
- Volume
- 64
- Issue
- 17
- Pages
- 6160-6165
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2156387230
- Cited by
- 304
- References
- 22
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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