The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst
Abstract
Aneurysmal bone cyst (ABC) is a locally aggressive osseous lesion that typically occurs during the first two decades of life. ABC was regarded historically as a nonneoplastic process, but recent cytogenetic data have shown clonal rearrangements of chromosomal bands 16q22 and 17p13, indicating a neoplastic basis in at least some ABCs. Herein we show that a recurring ABC chromosomal translocation t(16;17)(q22;p13) creates a fusion gene in which the osteoblast cadherin 11 gene (CDH11) promoter region on 16q22 is juxtaposed to the entire ubiquitin-specific protease USP6 (Tre2) coding sequence on 17p13. CDH11-USP6 fusion transcripts were demonstrated only in ABC with t(16;17) but other ABCs had CDH11 or USP6 rearrangements resulting from alternate cytogenetic mechanisms. CDH11 is expressed strongly in bone, and our findings implicate a novel oncogenic mechanism in which deregulated USP6 transcription results from juxtaposition to the highly active CDH11 promoter.
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Cites
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Self-citationThe Tre2 ( USP6 ) oncogene is a hominoid-specific gene
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Cited by
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Oliveira, A. M., Perez-Atayde, A. R., Dal Cin, P., Gebhardt, M. C., Chen, C.-J., Neff, J. R., Demetri, G. D., Rosenberg, A. E., Bridge, J. A., & Fletcher, J. A. (2005) · Oncogene · doi:10.1038/sj.onc.1208506 · Cited by 256
Self-citation
Metadata
- Authors
- Oliveira, A. M., Hsi, B.-L., Weremowicz, S., Rosenberg, A. E., Cin, P. D., Joseph, N., Bridge, J. A., Perez-Atayde, A. R., & Fletcher, J. A.
- Venue
- Cancer Research
- Published
- 2004-03-15
- Volume
- 64
- Issue
- 6
- Pages
- 1920-1923
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2125243526
- Cited by
- 313
- References
- 13
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oliveira, A. M., Hsi, B.-L., Weremowicz, S., Rosenberg, A. E., Cin, P. D., Joseph, N., Bridge, J. A., Perez-Atayde, A. R., & Fletcher, J. A. (2004). USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst. Cancer Research. https://doi.org/10.1158/0008-5472.can-03-2827
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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