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Cited by 275

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts.

Open access
Okazaki, M., Takeshita, S., Kawai, S., Kikuno, R., Tsujimura, A., Kudo, A., Amann, E.·1994·Journal of Biological Chemistry

Abstract

The preferential screening of cDNA libraries derived from the mouse osteoblastic cell line MC3T3-E1 has yielded a cDNA clone encoding 796 amino acids including the typical 24-residue-long signal sequence. The predicted amino acid sequence revealed that this protein constitutes a new member of the cadherin family. We propose the name OB-cadherin (OB for osteoblast) for this new protein. RNA analyses revealed that the OB-cadherin gene is selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels. Transfection of OB-cadherin cDNA into L cells resulted in the acquisition of the Ca(2+)-dependent adhesive property. Two different forms of the human OB-cadherin cDNA were subsequently cloned; one is a counterpart of mouse OB-cadherin gene, and the other encodes a protein with a truncated cytoplasmic domain. The results suggest that the newly found OB-cadherin might have an important role in bone formation.

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Metadata

Authors
Okazaki, M., Takeshita, S., Kawai, S., Kikuno, R., Tsujimura, A., Kudo, A., & Amann, E.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1994-04
Volume
269
Issue
16
Pages
12092-12098
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1587777046
Cited by
275
References
36
FWCI
3.68
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. https://app.cochat.ai/papers/10.1016/s0021-9258(17)32685-6
The paper
Okazaki, M., Takeshita, S., Kawai, S., Kikuno, R., Tsujimura, A., Kudo, A., & Amann, E. (1994). Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)32685-6

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.