The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays
Open accessAbstract
Changes in DNA copy number contribute to cancer pathogenesis. We now show that high-density single nucleotide polymorphism (SNP) arrays can detect copy number alterations. By hybridizing genomic representations of breast and lung carcinoma cell line and lung tumor DNA to SNP arrays, and measuring locus-specific hybridization intensity, we detected both known and novel genomic amplifications and homozygous deletions in these cancer samples. Moreover, by combining genotyping with SNP quantitation, we could distinguish loss of heterozygosity events caused by hemizygous deletion from those that occur by copy-neutral events. The simultaneous measurement of DNA copy number changes and loss of heterozygosity events by SNP arrays should strengthen our ability to discover cancer-causing genes and to refine cancer diagnosis.
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Cites
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Self-citationA human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
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Cited by
A haplotype map of the human genome
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The landscape of somatic copy-number alteration across human cancers
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Self-citationA collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
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Self-citationStructural Variation of Chromosomes in Autism Spectrum Disorder
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Metadata
- Authors
- Zhao, X., Li, C., Paez, J. G., Chin, K., Jänne, P. A., Chen, T.-H., Girard, L., Minna, J., Christiani, D., Leo, C., Gray, J. W., Sellers, W. R., & Meyerson, M.
- Venue
- Cancer Research
- Published
- 2004-05-01
- Volume
- 64
- Issue
- 9
- Pages
- 3060-3071
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2110227850
- Cited by
- 543
- References
- 28
- FWCI
- 32.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhao, X., Li, C., Paez, J. G., Chin, K., Jänne, P. A., Chen, T.-H., Girard, L., Minna, J., Christiani, D., Leo, C., Gray, J. W., Sellers, W. R., & Meyerson, M. (2004). An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays. Cancer Research. https://doi.org/10.1158/0008-5472.can-03-3308
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
