The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
X-Linked Inhibitor of Apoptosis Protein (XIAP) Is a Nonredundant Modulator of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)- Mediated Apoptosis in Human Cancer Cells
Abstract
Although the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to play an important role in the immunosurveillance of neoplasia, apoptotic factors that modulate the sensitivity of cancer cells to TRAIL are poorly understood. The inhibitor of apoptosis proteins (IAPs) have generated considerable interest as potential targets for cancer therapy, but the lack of a phenotype in X-linked IAP (XIAP) knockout mice has generated speculation that IAP function may be redundant. Using gene targeting technology, we show that disruption of the gene encoding XIAP in human cancer cells did not interfere with basal proliferation, but caused a remarkable sensitivity to TRAIL. These results demonstrate that XIAP is a nonredundant modulator of TRAIL-mediated apoptosis and provide a rationale for XIAP as a therapeutic target.
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“Apoptosis protein inhibitors (IAPs), such as XIAP, C-IAP1, C-IAP2, are a crucial class of endogenous anti-apoptosis proteins.453,454”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [453]
Citations
Cites
IAP family proteins---suppressors of apoptosisPreprint
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TRAIL and apoptosis induction by TNF-family death receptors
Wang, S., & El‐Deiry, W. S. (2003) · Oncogene · doi:10.1038/sj.onc.1207232 · Cited by 869
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Characterization of XIAP-Deficient Mice
Harlin, H., Reffey, S. B., Duckett, C. S., Lindsten, T., & Thompson, C. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3604-3608.2001 · Cited by 422
Nature's TRAIL—On a Path to Cancer Immunotherapy
Smyth, M. J., Takeda, K., Hayakawa, Y., Peschon, J. J., van den Brink, M. R. M., & Yagita∥, H. (2003) · Immunity · doi:10.1016/s1074-7613(02)00502-2 · Cited by 360
Targeted transgene insertion into human chromosomes by adeno-associated virus vectors
Hirata, R. K., Chamberlain, J. R., Dong, R., & Russell, D. W. (2002) · Nature Biotechnology · doi:10.1038/nbt0702-735 · Cited by 172
Guo, F., Nimmanapalli, R., Paranawithana, S. R., Wittmann, S., Griffin, D. R., Bali, P., O’Bryan, E., Fumero, C., Wang, H., & Bhalla, K. N. (2002) · Blood · doi:10.1182/blood.v99.9.3419 · Cited by 162
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Metadata
- Authors
- Cummins, J. M., Kohli, M., Rago, C., Kinzler, K. W., Vogelstein, B., & Bunz, F.
- Affiliations
- Johns Hopkins University (US)
- Sidney Kimmel Cancer Center (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cancer Research
- Published
- 2004-05-01
- Volume
- 64
- Issue
- 9
- Pages
- 3006-3008
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2074501845
- Cited by
- 200
- References
- 14
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 10 · 2016: 4 · 2015: 4 · 2014: 16 · 2013: 8 · 2012: 18
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA43460)
- National Institute of General Medical Sciences (T32GM007309, GM07309)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- XIAP, inhibitor of apoptosis proteins, TRAIL, TRAIL resistance, apoptosis, cancer cells, gene targeting, cancer therapy targets, immune surveillance
- MeSH terms
- Cell Survival, Colonic Neoplasms, Humans, Membrane Glycoproteins, Proteins, Tumor Necrosis Factor-alpha, Apoptosis, Caspases, HCT116 Cells, Cell Line, Tumor, Apoptosis Regulatory Proteins, X-Linked Inhibitor of Apoptosis Protein, TNF-Related Apoptosis-Inducing Ligand
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