The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
X-Linked Inhibitor of Apoptosis Protein (XIAP) Is a Nonredundant Modulator of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)- Mediated Apoptosis in Human Cancer Cells
Abstract
Although the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to play an important role in the immunosurveillance of neoplasia, apoptotic factors that modulate the sensitivity of cancer cells to TRAIL are poorly understood. The inhibitor of apoptosis proteins (IAPs) have generated considerable interest as potential targets for cancer therapy, but the lack of a phenotype in X-linked IAP (XIAP) knockout mice has generated speculation that IAP function may be redundant. Using gene targeting technology, we show that disruption of the gene encoding XIAP in human cancer cells did not interfere with basal proliferation, but caused a remarkable sensitivity to TRAIL. These results demonstrate that XIAP is a nonredundant modulator of TRAIL-mediated apoptosis and provide a rationale for XIAP as a therapeutic target.
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“Apoptosis protein inhibitors (IAPs), such as XIAP, C-IAP1, C-IAP2, are a crucial class of endogenous anti-apoptosis proteins.453,454”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [453]
Citations
Cites
IAP family proteins---suppressors of apoptosisPreprint
Deveraux, Q. L., & Reed, J. C. (1999) · Genes & Development · doi:10.1101/gad.13.3.239 · Cited by 2,535
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The inhibitors of apoptosis (IAPs) and their emerging role in cancer
LaCasse, E. C., Baird, S. D., Korneluk, R. G., & MacKenzie, A. (1998) · Oncogene · doi:10.1038/sj.onc.1202569 · Cited by 980
TRAIL and apoptosis induction by TNF-family death receptors
Wang, S., & El‐Deiry, W. S. (2003) · Oncogene · doi:10.1038/sj.onc.1207232 · Cited by 869
Fulda, S., Wick, W., Weller, M., & Debatin, K. (2002) · Nature Medicine · doi:10.1038/nm735 · Cited by 736
Wang, S. L., Hawkins, C. J., Yoo, S. J., Müller, H. ‐. J., & Hay, B. A. (1999) · Cell · doi:10.1016/s0092-8674(00)81974-1 · Cited by 517
Characterization of XIAP-Deficient Mice
Harlin, H., Reffey, S. B., Duckett, C. S., Lindsten, T., & Thompson, C. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3604-3608.2001 · Cited by 422
Nature's TRAIL—On a Path to Cancer Immunotherapy
Smyth, M. J., Takeda, K., Hayakawa, Y., Peschon, J. J., van den Brink, M. R. M., & Yagita∥, H. (2003) · Immunity · doi:10.1016/s1074-7613(02)00502-2 · Cited by 360
Targeted transgene insertion into human chromosomes by adeno-associated virus vectors
Hirata, R. K., Chamberlain, J. R., Dong, R., & Russell, D. W. (2002) · Nature Biotechnology · doi:10.1038/nbt0702-735 · Cited by 172
Guo, F., Nimmanapalli, R., Paranawithana, S. R., Wittmann, S., Griffin, D. R., Bali, P., O’Bryan, E., Fumero, C., Wang, H., & Bhalla, K. N. (2002) · Blood · doi:10.1182/blood.v99.9.3419 · Cited by 162
Cited by
Sorted by citations
Lu, H., Zhou, Q., He, J., Jiang, Z., Peng, C., Tong, R., & Shi, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00315-3 · Cited by 891
“Inhibitors of XIAP/caspase-9 interaction (small molecules) Inhibitors of apoptosis proteins (IAPs) are an important class of endogenous anti-apoptotic proteins.(90) They bind to the caspase or other pro-apoptotic proteins, results in the inhibition of the proapoptotic proteins functions and promotes their degradation,…”
BackgroundMutant PIK3CA promotes cell growth and invasion of human cancer cells.
Samuels, Y., Diaz, L. A., Schmidt-Kittler, O., Cummins, J. M., DeLong, L., Cheong, I., Rago, C., Huso, D. L., Lengauer, C., Kinzler, K. W., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.014 · Cited by 915
“TRAIL treatment was performed as described (Cummins et al., 2004a).”
MethodInfluentialSelf-citationIAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
Gyrd-Hansen, M., & Meier, P. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2889 · Cited by 790
“Conversely, cells that lack XIAP are sensitized to apoptosi”
BackgroundThe inhibitors of apoptosis (IAPs) as cancer targets
Hunter, A. M., LaCasse, E. C., & Korneluk, R. G. (2007) · Apoptosis · doi:10.1007/s10495-007-0087-3 · Cited by 565
“Targeted disruption in human HCT-116 colon carcinoma cells XIAP-null HCT-116 cells are remarkably sensitive to TRAIL in vitro [141] while XIAP-null HCT-116 tumor xenografts in mice are cured by adoptive cellular immunotherapy [142].”
BackgroundRecent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396
Metadata
- Authors
- Cummins, J. M., Kohli, M., Rago, C., Kinzler, K. W., Vogelstein, B., & Bunz, F.
- Affiliations
- Johns Hopkins University (US)
- Sidney Kimmel Cancer Center (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cancer Research
- Published
- 2004-05-01
- Volume
- 64
- Issue
- 9
- Pages
- 3006-3008
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2074501845
- Cited by
- 200
- References
- 14
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 10 · 2016: 4 · 2015: 4 · 2014: 16 · 2013: 8 · 2012: 18
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA43460)
- National Institute of General Medical Sciences (T32GM007309, GM07309)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- XIAP, inhibitor of apoptosis proteins, TRAIL, TRAIL resistance, apoptosis, cancer cells, gene targeting, cancer therapy targets, immune surveillance
- MeSH terms
- Cell Survival, Colonic Neoplasms, Humans, Membrane Glycoproteins, Proteins, Tumor Necrosis Factor-alpha, Apoptosis, Caspases, HCT116 Cells, Cell Line, Tumor, Apoptosis Regulatory Proteins, X-Linked Inhibitor of Apoptosis Protein, TNF-Related Apoptosis-Inducing Ligand
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