IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
Abstract
The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance, disease progression and poor prognosis, has sparked a worldwide frenzy in the development of small pharmacological inhibitors of IAPs. The development of such inhibitors has radically changed our knowledge of the signalling processes that are regulated by IAPs. Recent studies indicate that IAPs not only regulate caspases and apoptosis, but also modulate inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis, as well as cell invasion and metastasis.
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IAPs bind to caspase or other pro-apoptotic proteins, hinder their functions, promote their degradation, and thus regulate apoptosis.
“IAPs bind to caspase or other pro-apoptotic proteins, hinder their functions, promote their degradation, and thus regulate apoptosis.455,456”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [456]
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- Authors
- Gyrd-Hansen, M., & Meier, P.
- Affiliations
- Institute of Cancer Research (GB)
- ORCID
- Meier, Pascal
- Venue
- Nature Reviews Cancer
- Published
- 2010-08
- Volume
- 10
- Issue
- 8
- Pages
- 561-574
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1993262772
- Cited by
- 790
- References
- 6
- Citations by year
- 2026: 17 · 2025: 30 · 2024: 22 · 2023: 33 · 2022: 39 · 2021: 46 · 2020: 44 · 2019: 47 · 2018: 41 · 2017: 51 · 2016: 55 · 2015: 57 · 2014: 66 · 2013: 76 · 2012: 85
- FWCI
- 6.92
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-11-24)
- Open access
- closed
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- inhibitor of apoptosis proteins, IAP inhibitors, cIAP1, cIAP2, XIAP, caspase inhibition, apoptosis, NF-κB signaling, inflammation, chemoresistance, tumor progression, cell proliferation, mitosis, cell invasion, metastasis
- MeSH terms
- Animals, Humans, Inflammation, Neoplasm Metastasis, Neoplasms, Signal Transduction, NF-kappa B, Apoptosis, Lymphoma, B-Cell, Marginal Zone, Caspases, Ubiquitin, Inhibitor of Apoptosis Proteins, Toll-Like Receptors, Caspase Inhibitors
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