Integrin α4β1 Promotes Monocyte Trafficking and Angiogenesis in Tumors
Published version of a preprint
Abstract
Monocytes and macrophages extensively colonize solid tumors, where they are thought to promote tumor angiogenesis. Here, we show that integrin alpha4beta1 (VLA4) promotes the invasion of tumors by myeloid cells and subsequent neovascularization. Antagonists of integrin alpha4beta1, but not of other integrins, blocked the adhesion of monocytes to endothelium in vitro and in vivo as well as their extravasation into tumor tissue. These antagonists prevented monocyte stimulation of angiogenesis in vivo, macrophage colonization of tumors, and tumor angiogenesis. These studies indicate the usefulness of antagonists of integrin alpha4beta1 in suppressing macrophage colonization of tumors and subsequent tumor angiogenesis. These studies further indicate that suppression of myeloid cell homing to tumors could be a useful supplementary approach to suppress tumor angiogenesis and growth.
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α4β1/αvβ3 integrins are expressed in hematopoietic and endothelial cells and play a key role in inflammation.
“The α4β1/αvβ3 integrins are expressed in hematopoietic and endothelial cells [14] and play a key role in inflammation [15], [29], [46], [47].”
From Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo (2014) · cites this paper as [15]
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Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., et al. (2001) · Nature Medicine · doi:10.1038/nm1101-1194 · Cited by 1,860 · see citing works
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History of myeloid-derived suppressor cells
Talmadge, J. E., & Gabrilovich, D. I. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3581 · Cited by 1,148 · see citing works
Schmid, M. C., Avraamides, C. J., Dippold, H. C., Franco, I., Foubert, P., Ellies, L. G., Acevedo, L. M., Manglicmot, J. R. E., Song, X., Wrasidlo, W., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.04.016 · Cited by 378 · see citing works
Self-citationHaist, M., Stege, H., Grabbe, S., & Bros, M. (2021) · Cancers · doi:10.3390/cancers13020210 · Cited by 295 · see citing works
Mesenchymal Stem Cells in Cancer: Tumor-Associated Fibroblasts and Cell-Based Delivery Vehicles
Hall, B., Dembinski, J., Sasser, A., Studeny, M., Andreeff, M., & Marini, F. (2007) · International Journal of Hematology · doi:10.1532/ijh97.06230 · Cited by 171 · see citing works
Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo
Joshi, S., Singh, A. R., Zulcic, M., Bao, L., Messer, K., Ideker, T., Dutkowski, J., & Durden, D. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095893 · Cited by 128 · see citing works
Pleiotrophin: Activity and mechanism
(2020) · Advances in Clinical Chemistry · doi:10.1016/bs.acc.2020.02.003 · Cited by 98 · see citing works
Maenhout, S. K., Thielemans, K., & Aerts, J. L. (2014) · OncoImmunology · doi:10.4161/21624011.2014.956579 · Cited by 74 · see citing works
- Authors
- Jin, H., Su, J., Garmy-Susini, B., Kleeman, J., & Varner, J.
- Affiliations
- University of California San Diego (US)
- 1John and Rebecca Moores Comprehensive Cancer Center and
- Venue
- Cancer Research
- Published
- 2006-02-15
- Volume
- 66
- Issue
- 4
- Pages
- 2146-2152
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2089929639
- Cited by
- 127
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 12 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- alpha4beta1 integrin, VLA-4, monocyte trafficking, tumor angiogenesis, tumor-associated macrophages, integrin antagonists, extravasation, neovascularization, tumor invasion
- MeSH terms
- Animals, Cell Adhesion, Colonic Neoplasms, Humans, Leukocytes, Mononuclear, Macrophages, Mice, Nude, Neovascularization, Pathologic, Carcinoma, Lewis Lung, HT29 Cells, Myeloid Cells, Integrin alpha4beta1, Lymphangiogenesis, Endothelial Cells, Mice
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