Pleiotrophin: Activity and mechanism
Open accessAbstract
Pleiotrophin (PTN) is a potent mitogenic cytokine with a high affinity for the polysaccharide glycosaminoglycan (GAG). Although it is most strongly associated with neural development during embryogenesis and the neonatal period, its expression has also been linked to a plethora of other physiological events including cancer metastasis, angiogenesis, bone development, and inflammation. A considerable amount of research has been carried out to understand the mechanisms by which PTN regulates these events. In particular, PTN has now been shown to bind a diverse collection of receptors including many GAG-containing proteoglycans. These interactions lead to the activation of many intracellular kinases and, ultimately, activation and transformation of cells. Structural studies of PTN in complex with both GAG and domains from its non-proteoglycan receptors reveal a binding mechanism that relies on electrostatic interactions and points to PTN-induced receptor oligomerization as one of the possible ways PTN uses to control cellular functions.
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The Ptn-Ncl interaction facilitates internalization of the Ptn-Ncl complex.
“This interaction facilitates the internalization of the Ptn-Ncl complex [Wang, 2020].”
From Cell signaling pathways discovery from multi-modal data (2025) · cites this paper as Wang, 2020
The Nucleolin section (page unavailable) says cell-surface nucleolin interacts with PTN and presents its delivery of PTN into the nucleus as a hypothesis. The Structure of PTN section likewise says intracellular localization may result from their interaction. These passages support a possible transport role, but do not establish that the interaction facilitates internalization of a PTN–nucleolin complex. (LLM, conf=0.84)
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αMI-domain of integrin Mac-1 binds the cytokine pleiotrophin using multiple mechanisms
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Cell signaling pathways discovery from multi-modal data
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Targeting the PTN/PTPRZ1-ROS Pathway to Promote Bone Regeneration
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Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics
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An exposome-wide assessment of 6600 SomaScan proteins with non-genetic factors in Chinese adultsPreprint
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Short-term, Long-term, and Genetic Determinants of Human Plasma Proteome VariabilityPreprint
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- Authors
- Wang, X.
- Affiliations
- Arizona State University (US)
- Corresponding author
- Xu Wang
- ORCID
- Xu Wang
- Venue
- Advances in Clinical Chemistry
- Publisher
- Elsevier
- Published
- 2020
- Volume
- 98
- Pages
- 51-89
- ISSN
- 0065-2423 (ISSN-L)
- PMC
- PMC7672882
- OpenAlex
- W3011324370
- Cited by
- 98
- References
- 166
- Citations by year
- 2026: 22 · 2025: 16 · 2024: 26 · 2023: 22 · 2022: 10 · 2021: 2
- FWCI
- 14.22
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in clinical chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM118518)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Keywords
- pleiotrophin, glycosaminoglycan binding, proteoglycans, receptor oligomerization, electrostatic interactions, receptor activation, cell transformation, metastasis, angiogenesis, skeletal development, inflammation, neural development, protein structure
- MeSH terms
- Animals, Carrier Proteins, Cell Differentiation, Humans, Neoplasms, Cytokines
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