Oncogene-Induced Senescence: Putting the Brakes on Tumor Development

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477

The limited in vitro lifetime of human diploid cell strains

Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218

Regulation of chromatin structure by site-specific histone H3 methyltransferases

Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · cited 2×

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Beauséjour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., & Campisi, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg417 · Cited by 1,457

Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance

Scarpa, M., Ruffolo, C., Canal, F., Scarpa, M., Basato, S., Erroi, F., Fiorot, A., Dallagnese, L., Pozza, A., Porzionato, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6179 · Cited by 34

EBV finds a polycomb-mediated, epigenetic solution to the problem of oncogenic stress responses triggered by infection

Allday, M. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00212 · Cited by 32

Pathogenesis of bowel endometriosis

Yong, P. J., Bedaiwy, M. A., Alotaibi, F. T., & Anglesio, M. S. (2020) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2020.05.009 · Cited by 35

Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin

Yamaguchi, J., Sasaki, M., Harada, K., Zen, Y., Sato, Y., Ikeda, H., Itatsu, K., Yokoyama, Y., Ando, H., Ohta, T., et al. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.65 · Cited by 34

Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells

Keith, W. N., Thomson, C. M., Howcroft, J., Maitland, N. J., & Shay, J. W. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.06.009 · Cited by 32

Oncogenic BRAF and KRAS mutations in endosalpingiosis

Chui, M. H., & Shih, I. (2019) · The Journal of Pathology · doi:10.1002/path.5353 · Cited by 30

p53: a molecular marker for the detection of cancer

Boyd, M. T., & Vlatković, N. (2008) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2.9.1013 · Cited by 30

Dissecting the Senescence-like Program in Tumor Cells Activated by Ras Signaling

Bihani, T., Chicas, A., Lo, C. P.-K., & Lin, A. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608127200 · Cited by 30

Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process

Radiloff, D. R., Wakeman, T. P., Feng, J., Schilling, S. H., Seto, E., & Wang, X. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017269108 · Cited by 32

The Intricate Interplay between Mechanisms Underlying Aging and Cancer

Piano, A. (2014) · Aging and Disease · doi:10.14336/ad.2014.0209 · Cited by 28

Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence

Thorin‐Trescases, N., Labbé, P., Mury, P., Lambert, M., & Thorin, É. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212232 · Cited by 31

Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway

Chuang, J., & Hung, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.03.068 · Cited by 27

Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: A role in ovarian pathogenesis

Nanjundan, M., Cheng, K. W., Zhang, F., Lahad, J., Kuo, W.-L., Schmandt, R., Smith-McCune, K., Fishman, D., Gray, J. W., & Mills, G. B. (2008) · Molecular Oncology · doi:10.1016/j.molonc.2008.05.001 · Cited by 26

Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma

Lafferty‐Whyte, K., Bilsland, A. E., Cairney, C. J., Hanley, L., Jamieson, N. B., Zaffaroni, N., Oien, K. A., Burns, S., Roffey, J., Boyd, S. M., et al. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-532 · Cited by 25

Oncogene-Induced Senescence and its Role in Tumor Suppression

Reddy, J. P., & Li, Y. (2011) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-011-9221-5 · Cited by 25

High serum Hsp70 level predicts poor survival in colorectal cancer: Results obtained in an independent validation cohort

Gráf, L., Barabás, L., Madaras, B., Garam, N., Maláti, É., Horváth, L., Prohászka, Z., Horváth, Z., & Kocsis, J. (2018) · Cancer Biomarkers · doi:10.3233/cbm-181683 · Cited by 25

Stress-induced senescence exaggerates postinjury neointimal formation in the old vasculature

Khan, S. J., Pham, S. M., Wei, Y., Mateo, D., St-Pierre, M., Fletcher, T. M., & Vázquez-Padrón, R. I. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00501.2009 · Cited by 25

Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer

He, Y., Qiu, Y., Yang, X., Lu, G., & Zhao, S. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.11.002 · Cited by 25

The impact of cellular senescence in cancer therapy: is it true or not?

Zhang, Y., & Yang, J. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.108 · Cited by 24

The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence

Ask, T. F., Lugo, R. G., & Sütterlin, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00726 · Cited by 23

Role of Hsp70 in Cancer Growth and Survival

Hatfield, M. P. D., & Lovas, S. (2012) · Protein and Peptide Letters · doi:10.2174/092986612800493968 · Cited by 23

Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression

Paschos, K., Bazot, Q., Ho, G., Parker, G. A., Lees, J. G., Barton, G. R., & Allday, M. J. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1167 · Cited by 22

Chronic NF-κB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response

Batsi, C., Markopoulou, S., Vartholomatos, G., Georgiou, I. A., Kanavaros, P., Gorgoulis, V. G., Marcu, K. B., & Kolettas, E. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.04.002 · Cited by 22

Ultraviolet light exposure triggers nuclear accumulation of p21WAF1 and accelerated senescence in human normal and nucleotide excision repair‐deficient fibroblast strains

Mirzayans, R., Scott, A., Andrais, B., Pollock, S., & Murray, D. L. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21284 · Cited by 23

Senolytic Therapy: A Potential Approach for the Elimination of Oncogene-Induced Senescent HPV-Positive Cells

Saleh, T., Khasawneh, A. I., Himsawi, N. M., Abu-Raideh, J. A., Ejeilat, V., Elshazly, A. M., & Gewirtz, D. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415512 · Cited by 21

Translational control of cell fate: From integration of environmental signals to breaching anticancer defense

Bitterman, P. B., & Polunovsky, V. A. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19610 · Cited by 23

Accumulation of DNA Damage and Cell Death after Fractionated Irradiation

Řezáčová, M., Rudolfová, G., Tichý, A., Bačíková, A., Mutná, D., Havelek, R., Vávrová, J., Odrážka, K., Lukášová, E., & Kozubek, S. (2011) · Radiation Research · doi:10.1667/rr2478.1 · Cited by 20

hTERT Extends the Life of Human Fibroblasts without Compromising Type I Interferon Signaling

Smith, M. C., Goddard, E. T., Lanfranca, M. P., & Davido, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058233 · Cited by 21

Une re-vue de la sénescence cellulaire

Bischof, O., Dejean, A., & Pineau, P. (2009) · médecine/sciences · doi:10.1051/medsci/2009252153 · Cited by 30

Endothelial‐like cells derived directly from human tumor xenografts

Sajithlal, G. B., McGuire, T. F., Lu, J. L., Beer–Stolz, D., & Prochownik, E. V. (2010) · International Journal of Cancer · doi:10.1002/ijc.25251 · Cited by 21

Senescence‐secreted factors activate M yc and sensitize pretransformed cells to TRAIL‐induced apoptosis

Vjetrovic, J., Shankaranarayanan, P., Mendoza-Parra, M. A., & Gronemeyer, H. (2014) · Aging Cell · doi:10.1111/acel.12197 · Cited by 21

Proliferation Arrest in B-Raf Mutant Melanoma Cell Lines upon MAPK Pathway Activation

Houben, R., Ortmann, S., Drasche, A., Troppmair, J., Herold, M. J., & Becker, J. C. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.214 · Cited by 19

Identification of Hsc70 as target for AGE modification in senescent human fibroblasts

Unterluggauer, H., Micutkova, L., Lindner, H., Sarg, B., Hernebring, M., Nystrom, T., & Jansen-Dürr, P. (2009) · Biogerontology (Dordrecht) · doi:10.1007/s10522-008-9193-z · Cited by 18

The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21WAF1/CIP1-mediated cell cycle delay

Medendorp, K., van Groningen, J. J. M., Vreede, L., Hetterschijt, L., Brugmans, L., van den Hurk, H., & van Kessel, A. G. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.04.022 · Cited by 22

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

Dreute, J., Stengel, J., Becher, J., van den Borre, D. R., Pfisterer, M., Bartkuhn, M., Beutgen, V. M., Ndreshkjana, B., Gärtner, U., Graumann, J., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01532-5 · Cited by 21

Senescence-Associated Molecules and Tumor-Immune-Interactions as Prognostic Biomarkers in Colorectal Cancer

Kellers, F., Fernandez, A., Konukiewitz, B., Schindeldecker, M., Tagscherer, K. E., Heintz, A., Jesinghaus, M., Roth, W., & Foersch, S. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.865230 · Cited by 20

Robust Multiparametric Assessment of Cellular Senescence

Correia‐Melo, C., Jurk, D., & Passos, J. F. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-239-1_27 · Cited by 18

BCR-ABL but Not JAK2 V617F Inhibits Erythropoiesis through the Ras Signal by Inducing p21CIP1/WAF1

Tokunaga, M., Ezoe, S., Tanaka, H., Satoh, Y., Fukushima, K., Matsui, K., Shibata, M., Tanimura, A., Oritani, K., Matsumura, I., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118653 · Cited by 18

Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells

Wang, M., Chen, J., Song, S., Su, J., Zhao, L., Liu, Q., Yang, T., Chen, Z., Liu, C., Fu, Z., et al. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s296234 · Cited by 18

Human papillomavirus targets the YAP1-LATS2 feedback loop to drive cervical cancer development

Huang, C., Lv, X., Chen, P., Liu, J., He, C., Chen, L., Wang, H., Moness, M. L., Dong, J., Rueda, B. R., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02390-y · Cited by 18

Ras Downstream Effector GGCT Alleviates Oncogenic Stress

He, Z., Wang, S., Shao, Y., Zhang, J., Wu, X., Chen, Y., Hu, J., Zhang, F., & Liu, X. (2019) · iScience · doi:10.1016/j.isci.2019.07.036 · Cited by 16

Transcriptional landscape of oncogene-induced senescence: a machine learning-based meta-analytic approach

Han, Y., Micklem, G., & Kim, S. Y. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101849 · Cited by 16

Formation of vasculogenic mimicry in bone metastasis of prostate cancer: Correlation with cell apoptosis and senescence regulation pathways

Luo, F., Yang, K., Liu, R., Meng, C., Dang, R.-F., & Xu, Y. (2014) · Pathology - Research and Practice · doi:10.1016/j.prp.2014.01.005 · Cited by 16

Regulatory mechanisms, expression levels and proliferation effects of the FUS–DDIT3 fusion oncogene in liposarcoma

Åman, P., Dolatabadi, S., Švec, D., Jonasson, E., Safavi, S., Andersson, D., Grundevik, P., Thomsen, C., & Ståhlberg, A. (2016) · The Journal of Pathology · doi:10.1002/path.4700 · Cited by 17

Senescence in cancer: Hallmarks, paradoxes, and therapeutic promise

Hinterleitner, C., Goldberg, H. V., McHugh, D., Barthet, V. J. A., Filliol, A. A., & Lowe, S. W. (2026) · Cell · doi:10.1016/j.cell.2026.03.005 · Cited by 20

Senescent macrophages: A new “old” player in lung cancer development

Zhou, L., & Ruscetti, M. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.05.008 · Cited by 16

p14ARF Post-Transcriptional Regulation of Nuclear Cyclin D1 in MCF-7 Breast Cancer Cells: Discrimination between a Good and Bad Prognosis?

McGowan, E. M., Tran, N., Alling, N., Yagoub, D., Sedger, L. M., & Martiniello‐Wilks, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042246 · Cited by 16

Cell Senescence in Myxoid/Round Cell Liposarcoma

Gustafsson, C. K., Ståhlberg, A., Engtröm, K., Danielsson, A., Turesson, I., & Åman, P. (2014) · Sarcoma · doi:10.1155/2014/208786 · Cited by 14

Increased expression of hras induces early, but not full, senescence in the immortal fish cell line, EPC

Futami, K., Aoyama, K., Fukuda, K., Maita, M., & Katagiri, T. (2020) · Gene · doi:10.1016/j.gene.2020.145116 · Cited by 14

Targeting the Pro-survival Protein BCL-2 to Prevent Breast Cancer

Young, A. I. J., Bu, W., Jiang, W., Ku, A., Kapali, J., Dhamne, S., Qin, L., Hilsenbeck, S. G., Du, Y.-C. N., & Li, Y. (2021) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-21-0031 · Cited by 14

The senescence pathway in prostatic carcinogenesis

Sharma, S., Shin, J., Grimshaw, M. J., Clarke, R. A., & Lee, C. S. (2010) · Pathology · doi:10.3109/00313025.2010.508791 · Cited by 14

The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence

Li, X., Xu, H., Chong-an, X., Lin, M., Song, X., Yi, F., Feng, Y., Coughlan, K. A., Cho, W., Kim, S. W., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14022431 · Cited by 18

Exploring replication stress and cellular senescence as key targets in novel cancer therapies

Ray, S. K., & Mukherjee, S. (2025) · Cancer Genetics · doi:10.1016/j.cancergen.2025.09.002 · Cited by 14

Combinatorial Therapy Using Dovitinib and ICI182.780 (Fulvestrant) Blocks Tumoral Activity of Endometrial Cancer Cells

Eritja, N., Domingo, M., Dosil, M. A., Mirantes, C., Santacana, M., Valls, J., Llombart‐Cussac, A., Matías‐Guiu, X., & Dolcet, X. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0794 · Cited by 13

Amentoflavone-Enriched Selaginella rossii Protects against Ultraviolet- and Oxidative Stress-Induced Aging in Skin Cells

Lee, H., Kim, S.-Y., Lee, S.-W., Kwak, S., Li, H., Piao, R., Park, H.-Y., Choi, S., & Jeong, T. (2022) · Life · doi:10.3390/life12122106 · Cited by 14

Why is PAK4 overexpressed in cancer?

Costa, T. D. F., & Strömblad, S. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.106041 · Cited by 12

Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension

Aifuwa, I., Kim, B. C., Kamat, P., Starich, B., Agrawal, A., Tanrioven, D., Luperchio, T. R., Valencia, A. M. J., Perestrelo, T., Reddy, K. L., et al. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgac270 · Cited by 12

Navitoclax improves acute‐on‐chronic liver failure by eliminating senescent cells in mice

Watanabe, Y., Abé, H., Kimura, N., Arao, Y., Ishikawa, N., Yuichiro, M., Setsu, T., Sakamaki, A., Kamimura, H., Yokoo, T., et al. (2023) · Hepatology Research · doi:10.1111/hepr.13879 · Cited by 12

Pine needle hexane extract promote cell cycle arrest and premature senescence via p27KIP1 upregulation gastric cancer cells

Kim, W., Park, C., Park, J., Cheong, H., & Kim, S. (2020) · Food Science and Biotechnology · doi:10.1007/s10068-019-00730-5 · Cited by 13

Lack of a p16/ARF locus in fish genome may underlie senescence resistance in the fish cell line, EPC

Futami, K., Sato, S., Maita, M., & Katagiri, T. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104420 · Cited by 11

PI3Ks—Drug Targets in Inflammation and Cancer

Wymann, M. P. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3012-0_5 · Cited by 11

The Morphologic and Molecular Characteristics of Pilocytic Astrocytomas and the Role of MAPK Pathway

Aktaş, O. N., & Tihan, T. (2014) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000007 · Cited by 11

Synergism between RIZ1 gene therapy and paclitaxel in SiHa cervical cancer cells

Cheng, H., Zhang, T., Qu, Y., Shi, W. J., Lou, G., Liu, Y., Zhang, Y. Y., & Cheng, L. (2016) · Cancer Gene Therapy · doi:10.1038/cgt.2016.44 · Cited by 11

ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis

Kwon, O., Lee, H., Kim, Y.-J., Cha, H., Song, N., & Lee, M. (2020) · Cancers · doi:10.3390/cancers12040909 · Cited by 11

Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost during hepatocarcinogenesis

Ikeda, H., Sasaki, M., Sato, Y., Harada, K., Zen, Y., Mitsui, T., & Nakanuma, Y. (2009) · Pathology International · doi:10.1111/j.1440-1827.2009.02395.x · Cited by 11

Expression status of the autophagy‐regulatory gene ATG6/BECN1 in ERBB2‐positive breast carcinomas: Bypassing ERBB2‐induced oncogenic senescence to regulate the efficacy of ERBB2‐targeted therapies

Vázquez‐Martín, A., Cufí, S., Oliveras‐Ferraros, C., Martı́n-Castillo, B., Barco, S. D., López‐Bonet, E., & Menéndez, J. A. (2011) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20846 · Cited by 10

Discovery of 4H-chromeno[2,3-d]pyrimidin-4-one derivatives as senescence inducers and their senescence-associated antiproliferative activities on cancer cells using advanced phenotypic assay

Oh, S., Lee, J. Y., Choi, I., Ogier, A., Kwon, D. Y., Jeong, H., Son, S. J., Kim, Y., Kwon, H., Park, S., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112550 · Cited by 10

Impaired Mitochondria Promote Aging-Associated Sebaceous Gland Dysfunction and Pathology

Ahmed, N. S., Foote, J. B., & Singh, K. K. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.07.006 · Cited by 10

Knockdown of core binding factorβ alters sphingolipid metabolism

Greer, A. H., Yong, T., Fennell, K. A., Moustafa, Y. W., Fowler, M., Galiano, F. J., Ng, S., Berkowitz, R. S., Cardelli, J. A., Meyers, S., et al. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24406 · Cited by 10

Genome wide expression analysis of radiation-induced DNA damage responses in isogenic HCT116 p53+/+ and HCT116 p53−/− colorectal carcinoma cell lines

Lindgren, T., Stigbrand, T. I., Råberg, A., Riklund, K., Johansson, L. F., & Eriksson, D. (2014) · International Journal of Radiation Biology · doi:10.3109/09553002.2015.959668 · Cited by 10

The Dual Role of Senescence in Tumorigenesis

Chuaire, L., Sánchez, M. C., & Ramírez-Clavijo, S. R. (2010) · International Journal of Morphology · doi:10.4067/s0717-95022010000100006 · Cited by 10

Temporally distinct roles for tumor suppressor pathways in cell cycle arrest and cellular senescence in Cyclin D1-driven tumor

Zalzali, H., Harajly, M., Abdul-Latif, L., El-Chaar, N. N., Dbaibo, G. S., Skapek, S. X., & Saab, R. H. (2012) · Molecular Cancer · doi:10.1186/1476-4598-11-28 · Cited by 10

Ring-Like Distribution of Constitutive Heterochromatin in Bovine Senescent Cells

Pichugin, A., Beaujean, N., Vignon, X., & Vassetzky, Y. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026844 · Cited by 10

Novel cellular senescence-related risk model identified as the prognostic biomarkers for lung squamous cell carcinoma

Hu, X., Guo, L., Liu, G., Dai, Z., Wang, L., Zhang, J., & Wang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.997702 · Cited by 10

Screening and Treating Prostate Cancer in the Older Patient: Decision Making Across the Clinical Spectrum

Morgans, A. K., Dale, W., & Briganti, A. (2017) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_175491 · Cited by 9

Alteration in gene expression profile and oncogenicity of esophageal squamous cell carcinoma byRIZ1upregulation

Dong, S. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i37.6170 · Cited by 8

Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence

Gupta, K. P., Dholaniya, P. S., Chekuri, A., & Kondapi, A. K. (2015) · AGE · doi:10.1007/s11357-015-9789-6 · Cited by 8

Regenerative Medicine

Marongiu, F., Serra, M. P., Fanti, M., Cadoni, E., Serra, M., & Laconi, E. (2017) · Cell Transplantation · doi:10.1177/0963689717721224 · Cited by 7

Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue

Khasawneh, A. I., Shboul, S. A., Himsawi, N. M., Rousan, A. A., Shahin, N. A., El‐Sadoni, M., Alhesa, A., Ghalioun, A. A., Khawaldeh, S., Shawish, B., et al. (2025) · BMC Cancer · doi:10.1186/s12885-025-13499-0 · Cited by 7

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Xia, N., Cai, J., Wang, F., Dong, B., Liu, S., Chen, F., Cheng, J., & Zuo, Y. (2016) · Scientific Reports · doi:10.1038/srep34099 · Cited by 7

Targeting senescent cells and tumor therapy (Review)

Wang, Z., Gao, J., Liu, H., Ohno, Y., & Xu, C. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4705 · Cited by 8

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Trumpp, A. (2007) · Springer eBooks · doi:10.1007/2789_2007_042 · Cited by 8

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Chowdhury, S. R., Murphy, K. C., Parikh, C. N., DeMarco, K. D., Zhou, L., & Ruscetti, M. A. (2024) · Methods in cell biology · doi:10.1016/bs.mcb.2024.07.010 · Cited by 6

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Shlush, L. I., & Selig, S. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-556-9_2 · Cited by 6

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Lazarus, A., Banerjee, K. K., & Kolthur‐Seetharam, U. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4525-4_8 · Cited by 6

Senotherapy for attenuation of cellular senescence in aging and organ implantation

Kang, D. H., Park, Y. S., & Lee, D. Y. (2017) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2017.08.053 · Cited by 6

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Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers

Dosch, A. R., Chatila, W. K., Ban, Y. J., Bianchi, A., Deshpande, N. U., Silva, I. D. C., Merchant, N. B., & Datta, J. (2021) · Oncotarget · doi:10.18632/oncotarget.27983 · Cited by 5

Resistance to mutant KRAS-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line

Muraki, N., Yamada, M., Doki, H., Nakai, R., Komeda, K., Goto, D., Kawabe, N., Matsuoka, K., Matsushima, M., Kawabe, T., et al. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113053 · Cited by 5

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Turnham, D. J., Smith, H., & Clarkson, R. W. E. (2024) · Biomedicines · doi:10.3390/biomedicines12010143 · Cited by 4

Nevogenesis: Changing Theories

Burnett, M. E., Marghoob, A. A., & Scope, A. (2012) · Springer eBooks · doi:10.1007/978-3-642-28397-0_1 · Cited by 4

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Krause, A., Conboy, M. J., & Conboy, I. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802734-9.00012-3 · Cited by 4

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Ponnamperuma, R. M., King, K. E., Elsir, T., Glick, A. B., Wahl, G. M., Nistér, M., & Weinberg, W. C. (2009) · The Journal of Pathology · doi:10.1002/path.2600 · Cited by 4

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Meiliana, A., Dewi, N. M., & Wijaya, A. (2015) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v7i2.72 · Cited by 3

Erratum to: Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence

Gupta, K. P., Dholaniya, P. S., Chekuri, A., & Kondapi, A. K. (2015) · AGE · doi:10.1007/s11357-015-9810-0 · Cited by 4

Ras Mutations in Cancer

Barault, L., Lamba, S., & Nicolantonio, F. D. (2013) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0025010 · Cited by 4

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Gorbunova, V. A., & Seluanov, A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1075-2_7 · Cited by 2

Basics of Molecular Biology

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Prx1/PHB2 axis mediates mitophagy in oral leukoplakia cellular senescence

Lu, Y., Li, L., Li, J., Wang, M., Yang, J., Zhang, M., Jiang, Q., & Tang, X. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155411 · Cited by 2

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Wei, B., Yu, Q., Jin, J., Zhu, D., Lai, B., Gu, J., Yang, R., Huang, H., Lin, H., Zhang, L., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02247-2 · Cited by 3

Cellular senescence: Its role in tumor suppression and aging

Ohtani, N., Mann, D. J., & Hara, E. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01123.x · Cited by 119

Senescence comes of age

Narita, M., & Lowe, S. W. (2005) · Nature Medicine · doi:10.1038/nm0905-920 · Cited by 153

Oncogene-Induced Cell Senescence — Halting on the Road to Cancer

Mooi, W. J., & Peeper, D. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062285 · Cited by 371

Senescence is a defensive mechasim against oncogene-induced tumorigenesis

Zhang, H. (2008) · Basic & Clinical Medicine · Cited by 1

Cellular senescence in vivo: a barrier to tumorigenesis

Prieur, A., & Peeper, D. S. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.007 · Cited by 260