The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Impaired Notch Signaling Promotes De novo Squamous Cell Carcinoma Formation
Open accessAbstract
Signaling through Notch receptors in the skin has been implicated in the differentiation, proliferation, and survival of keratinocytes, as well as in the pathogenesis of basal cell carcinoma (BCC). To determine the composite function of Notch receptor–mediated signaling in the skin and overcome potential redundancies between receptors, conditional transgenic mice were generated that express the pan-Notch inhibitor, dominant-negative Mastermind Like 1 (DNMAML1), to repress all canonical [CBF-1/Suppressor of hairless/LAG-1 (CSL)–dependent] Notch signaling exclusively in the epidermis. Here, we report that DNMAML1 mice display hyperplastic epidermis and spontaneously develop cutaneous squamous cell carcinoma (SCC) as well as dysplastic precursor lesions, actinic keratoses. Mice expressing epidermal DNMAML1 display enhanced accumulation of nuclear β-catenin and cyclin D1 in suprabasilar keratinocytes and in lesional cells from SCCs, which was also observed in human cutaneous SCC. These results suggest a model wherein CSL-dependent Notch signaling confers protection against cutaneous SCC. The demonstration that inhibition of canonical Notch signaling in mice leads to spontaneous formation of SCC and recapitulates the disease in humans yields fundamental insights into the pathogenesis of SCC and provides a unique in vivo animal model to examine the pathobiology of cutaneous SCC and for evaluating novel therapies. (Cancer Res 2006; 66(15): 7438-44)
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Cites
NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
Dajee, M., Lazarov, M., Zhang, J. Y., Cai, T., Green, C. L., Russell, A. J., Marinkovich, M. P., Tao, S., Lin, Q., Kubo, Y., et al. (2003) · Nature · doi:10.1038/nature01283 · Cited by 535
Devgan, V., Mammucari, C., Millar, S. E., Brisken, C., & Dotto, G. P. (2005) · Genes & Development · doi:10.1101/gad.341405 · Cited by 209
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Cited by
Notch signaling pathway: architecture, disease, and therapeutics
Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,114
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Liu, J., Pan, S., Hsieh, M. H., Ng, N., Sun, F., Wang, T., Kasibhatla, S., Schuller, A. G., Li, A. G., Cheng, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314239110 · Cited by 831
The Varied Roles of Notch in Cancer
Aster, J. C., Pear, W. S., & Blacklow, S. C. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100127 · Cited by 710
Self-citationNotch Promotes Radioresistance of Glioma Stem Cells
Wang, J., Wakeman, T. P., Lathia, J. D., Hjelmeland, A. B., Wang, X.-F., White, R. R., Rich, J. N., & Sullenger, B. A. (2010) · Stem Cells · doi:10.1002/stem.261 · Cited by 656
Signaling Involved in Hair Follicle Morphogenesis and Development
Rishikaysh, P., Dev, K., Diaz, D., Qureshi, W., Filip, S., & Mokry, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011647 · Cited by 393
Metadata
- Authors
- Proweller, A., Tu, L., Lepore, J. J., Cheng, L., Lu, M. M., Seykora, J., Millar, S. E., Pear, W. S., & Parmacek, M. S.
- Venue
- Cancer Research
- Published
- 2006-08-01
- Volume
- 66
- Issue
- 15
- Pages
- 7438-7444
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2140357331
- Cited by
- 213
- References
- 2
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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