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CD151 Accelerates Breast Cancer by Regulating α6 Integrin Function, Signaling, and Molecular Organization
Open accessPublished version of a preprint
Abstract
CD151, a master regulator of laminin-binding integrins (alpha(6)beta(4), alpha(6)beta(1), and alpha(3)beta(1)), assembles these integrins into complexes called tetraspanin-enriched microdomains. CD151 protein expression is elevated in 31% of human breast cancers and is even more elevated in high-grade (40%) and estrogen receptor-negative (45%) subtypes. The latter includes triple-negative (estrogen receptor, progesterone receptor, and HER2 negative) basal-like tumors. CD151 ablation markedly reduced basal-like mammary cell migration, invasion, spreading, and signaling (through FAK, Rac1, and lck) while disrupting epidermal growth factor receptor (EGFR)-alpha(6) integrin collaboration. Underlying these defects, CD151 ablation redistributed alpha(6)beta(4) integrins subcellularly and severed molecular links between integrins and tetraspanin-enriched microdomains. In a prototypical basal-like mammary tumor line, CD151 ablation notably delayed tumor progression in ectopic and orthotopic xenograft models. These results (a) establish that CD151-alpha(6) integrin complexes play a functional role in basal-like mammary tumor progression; (b) emphasize that alpha(6) integrins function via CD151 linkage in the context of tetraspanin-enriched microdomains; and (c) point to potential relevance of CD151 as a high-priority therapeutic target, with relative selectivity (compared with laminin-binding integrins) for pathologic rather than normal physiology.
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“ITGB1 and CD151 are known to be pro-tumorigenic by enhancing cell migration and stromal invasion (Reuter et al., 2009, White et al., 2004, Yang et al., 2008, Zijlstra et al., 2008).”
From Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020) · cites this paper as Yang et al., 2008
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Cites
Molecular portraits of human breast tumours
Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., Clark, L., Bayani, N., Coppé, J., Tong, F. K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.008 · Cited by 3,224
Focal adhesion kinase: in command and control of cell motility
Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,657
Tetraspanin functions and associated microdomains
Hemler, M. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1736 · Cited by 1,355 · cited 1×
“CD151 may link laminin-binding integrins to other proteins within the plasma membrane (38, 39).”
BackgroundSelf-citationHemler, M. E. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.153609 · Cited by 831
Self-citationActivation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion
Shaw, L. M., Rabinovitz, I., Wang, H. H.-F., Toker, A., & Mercurio, A. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80486-9 · Cited by 613
Complexes of tetraspanins with integrins: more than meets the eye
Berditchevski, F. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.23.4143 · Cited by 597
Genetic programs of epithelial cell plasticity directed by transforming growth factor-β
Zavadil, J., Bitzer, M., Liang, D., Yang, Y.-C., Massimi, A. B., Kneitz, S., Piek, E., & Böttinger, E. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111614398 · Cited by 534
Control of motile and invasive cell phenotypes by focal adhesion kinase
Schlaepfer, D. D., Mitra, S. K., & Ilić, D. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.04.008 · Cited by 475
β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis
Guo, W., Pylayeva, Y., Pepe, A., Yoshioka, T., Muller, W. J., Inghirami, G., & Giancotti, F. G. (2006) · Cell · doi:10.1016/j.cell.2006.05.047 · Cited by 466
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Wang, Z., Wang, C., Zhou, Z., Sun, M., Zhou, C., Chen, J., Yin, F., Wang, H., Lin, B., Zuo, D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11380 · Cited by 22
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Finke, J., Mikuličić, S., Loster, A.-L., Gawlitza, A., Florin, L., & Lang, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-62202-9 · Cited by 22
Scales, T. M. E., Jayo, A., Obara, B., Holt, M., Hotchin, N. A., Berditchevski, F., & Parsons, M. (2012) · Oncogene · doi:10.1038/onc.2012.415 · Cited by 21
TIMP-1 and CD82, a promising combined evaluation marker for PDAC
Zhang, J., Wu, T., Zhan, S., Qiao, N., Zhang, X., Zhu, Y., Yang, N., Sun, Y., Zhang, X. A., Bleich, D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14133 · Cited by 21
Expression of KAI1/CD82 in distant metastases from estrogen receptor‐negative breast cancer
Christgen, M., Christgen, H., Heil, C., Krech, T., Länger, F. P., Kreipe, H. H., & Lehmann, U. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01231.x · Cited by 21
Mosig, R., Lin, L., Senturk, E., Shah, H., Huang, F., Schlosshauer, P. W., Cohen, S., Fruscio, R., Marchini, S., D’Incalci, M., et al. (2012) · Journal of Ovarian Research · doi:10.1186/1757-2215-5-4 · Cited by 21
Prognostic significance of tetraspanin CD151 in newly diagnosed glioblastomas
Lee, D., Suh, Y., Park, T. I., Do, I., Seol, H. J., Nam, D., & Kim, S. T. (2012) · Journal of Surgical Oncology · doi:10.1002/jso.23249 · Cited by 20
Zevian, S., Johnson, J. L., Winterwood, N. E., Walters, K. S., Herndon, M. E., Henry, M. D., & Stipp, C. S. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1095396 · Cited by 19
TSPAN8 serves as a prognostic marker involving Akt/MAPK pathway in nasopharyngeal carcinoma
Lin, X., Bi, Z., Hu, Q., Li, Q., Liu, J., Luo, M., Xiang, Y., & Yao, H. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.08.02 · Cited by 19
Tetraspanins in mammalian reproduction: spermatozoa, oocytes and embryos
Jankovičová, J., Neuerová, Z., Sečová, P., Bartóková, M., Bubeníčková, F., Komrsková, K., Manaskova-Postlerova, P., & Antalíková, J. (2020) · Medical Microbiology and Immunology · doi:10.1007/s00430-020-00676-0 · Cited by 18
Weitzenfeld, P., Meron, N., Leibovich-Rivkin, T., Meshel, T., & Ben‐Baruch, A. (2013) · Mediators of Inflammation · doi:10.1155/2013/720536 · Cited by 18
Laminin‐421 produced by lymphatic endothelial cells induces chemotaxis for human melanoma cells
Saito, N., Hamada, J., Furukawa, H., Tsutsumida, A., Oyama, A., Funayama, E., Saito, A., Tsuji, T., Tada, M., Moriuchi, T., et al. (2009) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2009.00590.x · Cited by 18
The tetraspanin CD151 marks a unique population of activated human T cells
Perez, M. D., Seu, L., Lowman, K. E., Moylan, D. C., Tidwell, C., Samuel, S., Duverger, A. E., Wagner, F. H., Carlin, E., Sharma, V. K., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72719-8 · Cited by 17
Virtanen, S., Schulte, R., Stingl, J., Caldas, C., & Shehata, M. (2021) · Breast Cancer Research · doi:10.1186/s13058-021-01444-5 · Cited by 17
Gavara, M. M., Zaveri, K., Badana, A. K., Gugalavath, S., Amajala, K. C., Patnala, K., & Malla, R. R. (2017) · Process Biochemistry · doi:10.1016/j.procbio.2017.12.004 · Cited by 16
Tetraspanin CD151 expression associated with prognosis for patients with advanced gastric cancer
Kang, B. W., Lee, D., Chung, H. Y., Han, J. H., & Kim, Y. (2013) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-013-1503-4 · Cited by 15
Aggarwal, A., Al-Rohil, R. N., Batra, A., Feustel, P. J., Jones, D., & DiPersio, C. M. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-459 · Cited by 15
Li, H., Li, J., Han, R., Deng, X., Shi, J., Huang, H., Hamad, N., McCaughley, A., Liu, J., Wang, C., et al. (2019) · Neoplasia · doi:10.1016/j.neo.2019.08.005 · Cited by 15
Self-citationLi, D., Lai, W., Wang, Q., Xiang, Z., Nan, X., Yang, X., & Fang, Q. (2021) · Biochimie · doi:10.1016/j.biochi.2021.06.007 · Cited by 15
Self-citationCD151 Expression Is Associated with a Hyperproliferative T Cell Phenotype
Seu, L., Tidwell, C., Timares, L., Duverger, A. E., Wagner, F. H., Goepfert, P., Westfall, A. O., Sabbaj, S., & Kutsch, O. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700648 · Cited by 15
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Yin, Y., Deng, X., Liu, Z., Baldwin, L. A., Lefringhouse, J., Zhang, J., Hoff, J. J., Erfani, S., Rucker, E. B., O’Connor, K. L., et al. (2014) · Cell Cycle · doi:10.4161/15384101.2015.945823 · Cited by 15
Self-citationLin, B., Zhang, W.-B., Jing, Z., Zhou, X., Li, Y., Deng, J., Zhao, Q., Fu, G., Xie, C., Xu, Y., et al. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s312921 · Cited by 14
Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model
Roselli, S., Kahl, R. G. S., Copeland, B. T., Naylor, M. J., Weidenhofer, J., Muller, W. J., & Ashman, L. K. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-509 · Cited by 13
CD151 promotes cell metastasis via activating TGF-β1/Smad signaling in renal cell carcinoma
Yu, Y., Liang, C., Wang, S., Zhu, J., Miao, C., Hua, Y., Bao, M., Cao, Q., Qin, C., Shao, P., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24028 · Cited by 13
Joint features and complementarities of Tspan8 and CD151 revealed in knockdown and knockout models
Yue, S., Zhao, K., Erb, U., Rana, S., & Zöller, M. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160298 · Cited by 13
Kelil, A., Gallo, E., Banerjee, S., Adams, J., & Sidhu, S. S. (2021) · Communications Biology · doi:10.1038/s42003-021-02066-5 · Cited by 12
MMP26: A potential biomarker for prostate cancer
Cheng, T., Li, F., Wei, R., Lv, M., Zhou, Y., Dai, Y., Yuan, Y., Jiang, G.-Y., Ma, D., & Gao, Q. (2017) · Current Medical Science · doi:10.1007/s11596-017-1823-8 · Cited by 12
Dynamic Change of Tetraspanin CD151 Membrane Protein Expression in Colorectal Cancer Patients
Lin, P., Lin, S.-C., Lee, C., Lin, Y., & Lee, J. (2011) · Cancer Investigation · doi:10.3109/07357907.2011.606251 · Cited by 11
Integrin-associated CD151 is a suppressor of prostate cancer progression.
Han, R., Hensley, P. J., Li, J., Zhang, Y., Stark, T. W., Heller, A., Qian, H., Shi, J., Liu, Z., Huang, J., et al. (2020) · PubMed Central · Cited by 11
Self-citationThe Functional Importance of Tetraspanins in Exosomes
Rana, S., & Zöller, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3697-3_4 · Cited by 11
Therapeutic targeting of membrane-associated proteins in central nervous system tumors
Roy, P., Rajesh, Y., & Mandal, M. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112760 · Cited by 10
Production of human tetraspanin proteins in Escherichia coli
Tarry, M. J., Skaar, K., von HEIJNE, G., Draheim, R. R., & Högbom, M. (2012) · Protein Expression and Purification · doi:10.1016/j.pep.2012.02.003 · Cited by 9
Tetraspanin CD151 impairs heterodimerization of ErbB2/ErbB3 in breast cancer cells
Mieszkowska, M., Piasecka, D., Potemski, P., Dębska-Szmich, S., Rychłowski, M., Kordek, R., Sądej, R., & Romańska, H. (2018) · Translational research · doi:10.1016/j.trsl.2018.12.007 · Cited by 9
Tetraspanin CD151 mediates communication between prostate cancer cells and osteoblasts
Grudowska, A., Czaplińska, D., Połom, W., Matuszewski, M., Sądej, R., & Składanowski, A. C. (2017) · Acta Biochimica Polonica · doi:10.18388/abp.2016_1356 · Cited by 9
Liu, T., Wang, S., Wang, L., Wang, J., & Li, Y. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2459-2 · Cited by 9
Organisation of the Tetraspanin Web
Rubinstein, E., Charrin, S., & Tomlinson, M. G. (2013) · Springer eBooks · doi:10.1007/978-94-007-6070-7_3 · Cited by 8
Regulation of FAK Activity by Tetraspan Proteins: Potential Clinical Implications in Cancer
Yu, Q., Mohandessi, S., Gordon, L. K., & Wadehra, M. (2015) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v20.i5-6.110 · Cited by 8
Romańska, H., Potemski, P., Kusińska, R., Kopczyński, J., Sądej, R., & Kordek, R. (2015) · PubMed Central · Cited by 8
The Role of Exosomal Tetraspanins and Proteases in Tumor Progression
Yunusova, N. V., Tugutova, E. A., TAMKOVICH, S. N., & Кондакова, И. В. (2018) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750818030095 · Cited by 8
Wong, A. H., Nga, M. E., Chin, C. Y., Tai, Y. K., Wong, H. C., Soo, R. A., An, Ö., Yang, H. H., Seet, J. E., Lim, Y. C., et al. (2024) · Cell Proliferation · doi:10.1111/cpr.13708 · Cited by 7
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McCabe, K. L., & Bronner-Fraser, M. E. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07190.x · Cited by 6
The requirement of integrins for breast epithelial proliferation
Moreno‐Layseca, P., Uçar, A., Sun, H., Wood, A., Olabi, S., Gilmore, A. P., Brennan, K. R., & Streuli, C. H. (2017) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2017.03.005 · Cited by 6
Hou, Y., Xia, H., Xu, C., Yu, Y., Ji, C., Ruan, W., Kong, W., Zhou, Y., & Zhang, X. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01634-w · Cited by 5
Purushothaman, G., & Thiruvenkatam, V. (2019) · Molecular Biotechnology · doi:10.1007/s12033-019-00212-3 · Cited by 5
Palmer, T. D., & Zijlstra, A. (2011) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a004123.01 · Cited by 4
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Nienstedt, J. C., Gröbe, A., Lebok, P., Büscheck, F., Clauditz, T. S., Simon, R., Heumann, A., Sauter, G., Moebius, C., Münscher, A., et al. (2016) · Clinical Oral Investigations · doi:10.1007/s00784-016-1911-3 · Cited by 4
Ashman, L. K., & Zöller, M. (2013) · Springer eBooks · doi:10.1007/978-94-007-6070-7_11 · Cited by 5
Zakaria, Z., Bong, I. P. N., Bagali, P. G., Muhammad, R., Abdullah, N., Ibrahim, N., Emran, N. A., Abdullah, N. H., & Hussain, S. N. A. S. (2010) · The Open Breast Cancer Journal · doi:10.2174/1876817201002010016 · Cited by 3
CD151 up-regulation contributes to the invasion of pituitary adenomas.
Li, S., Wu, C., Gao, H., Wu, X., Yu, L., Tao, B., & Hong, Y. K. (2018) · PubMed Central · Cited by 3
Tran, M. H., Freitas, T. C., Cooper, L. T., Gaze, S. T., Gatton, M. L., Jones, M. K., Lovas, E. M., Pearce, E. J., & Loukas, A. C. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000840 · Cited by 2
Genetic Evidence for Tetraspanin Functions
Hemler, M. E. (2013) · Springer eBooks · doi:10.1007/978-94-007-6070-7_7 · Cited by 1
Self-citationTetraspanins and Cancer Metastasis
Zöller, M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6615-5_26 · Cited by 1
Roles of Integrins in the Development and Progression of Squamous Cell Carcinomas
Lamar, J. M., & DiPersio, C. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7203-3_2 · Cited by 1
Liu, T., Zhou, L., & Rong, W. (2012) · International Conference on Biomedical Engineering and Biotechnology · doi:10.1109/icbeb.2012.330 · Cited by 1
The Role of Tetraspanins in Cell Migration and Intercellular Adhesion
Tejera, E., Sala-Valdés, M., Rocha‐Perugini, V., & Yáñez‐Mó, M. (2013) · Springer eBooks · doi:10.1007/978-94-007-6070-7_6
Emerging links of CD151 and Integrins to Tumorigenesis and EMT Induction in Ovarian Cancer
(2015) · Cancer Cell & Microenvironment · doi:10.14800/ccm.670
Studies on Memo, an important ErbB2 receptor-mediated component of the cellular migratory machinery
Meira, M. (2009) · edoc (University of Basel) · doi:10.5451/unibas-004780709
Use of tetraspanins CD151 and CD9 as biomarkers for breast cancer
Bond, D. R., Brzozowski, J. S., Skelding, K. A., Roselli, S., & Weidenhofer, J. (2014) · Breast Cancer Management · doi:10.2217/bmt.14.2
CD151 (CD151 molecule (Raph blood group))
Weidenhofer, J., & Ashman, L. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/44770
Liu, T., & Rong, W. (2012) · International Conference on Biomedical Engineering and Biotechnology · doi:10.1109/icbeb.2012.215
Determining the Effects of CD151 and β 1 on Tumor Cell Adhesion and Migration
Essex, R. R. (2015) · UKnowledge (University of Kentucky)
UNIVERSITÁ DEGLI STUDI DI MILANO FACOLTÁ DI MEDICINA E CHIRURGIA
Ricerca, D. D. (2010)
Shema, E., Tirosh, I., & Aylon, Y. (2008)
Sutherland, R. L. (2008) · Breast Cancer Online · doi:10.1017/s1470903108008420
Chang, C. (2015) · eScholarship@UMassChan · doi:10.13028/m2vg60
El-Dien, M. M. S., Gadallah, M., Alhanafy, A. M., & Holah, N. S. (2024) · Egyptian Journal of Pathology · doi:10.4103/egjp.egjp_20_24
CD151 interacts with integrin beta 2 in B cell lymphomas
Hagemann, P. M., Kenyon, A. N., Cabrera‐Orefice, A., Arp, A. B., Hesius, E. A. M., van den Brand, M., van Deventer, S. J., de Jong, D., Scheijen, B., Xu-Monette, Z. Y., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05747-0
Voss, M. A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Virtanen, S., Schulte, R., Stingl, J., Caldas, C., & Shehata, M. (2021) · Figshare · doi:10.6084/m9.figshare.14776646
Virtanen, S., Schulte, R., Stingl, J., Caldas, C., & Shehata, M. (2021) · Figshare · doi:10.6084/m9.figshare.14776643
Virtanen, S., Schulte, R., Stingl, J., Caldas, C., & Shehata, M. (2021) · Figshare · doi:10.6084/m9.figshare.14776655
Virtanen, S., Schulte, R., Stingl, J., Caldas, C., & Shehata, M. (2021) · Figshare · doi:10.6084/m9.figshare.14776652
Cytotoxic and immunomodulatory activity of CD151-LEL-based peptides in breast cancer and THP-1 cells
Vempati, R. K., & Malla, R. R. (2026) · Human Immunology · doi:10.1016/j.humimm.2026.111676
Rôle et modes d'action de la Tétraspanine 8 dans l'invasion précoce du mélanome cutané
Kharbili, M. E. (2013) · theses.fr (ABES) · doi:10.70675/3e596898z95f7z4eb2za2aaz44ee31529d70
Influence of gangliosides in the dynamics and partitioning of CD82 and its partners
Fernandez, L. (2017) · theses.fr (ABES) · doi:10.70675/fb9b9b63zf102z44b4z90f9z2f1908d70871
Manzano, R. N. (2022) · theses.fr (ABES) · doi:10.70675/8f71254bz5af6z4fdbz8550z05cb2822e327
Perez, M. D., Zhu, F., Carlin, E., Greer, B. D., Schroeder, A. R., Lowman, K. E., Opsteen, S., Fram, T., Tidwell, C., Duverger, A. E., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag208
Structural basis for tetraspanin-dependent surface export and adhesive function of integrin α3β1Preprint
Litzau, L. A., Wren, E., Kruse, A. C., & Blacklow, S. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.01.748654
Metadata
- Authors
- Yang, X. H., Richardson, A. L., Torres-Arzayus, M. I., Zhou, P., Sharma, C., Kazarov, A. R., Andzelm, M. M., Strominger, J. L., Brown, M., & Hemler, M. E.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- 2Medical Oncology, and
- ORCID
- Venue
- Cancer Research
- Published
- 2008-05-01
- Volume
- 68
- Issue
- 9
- Pages
- 3204-3213
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC4764302
- OpenAlex
- W2102040455
- Cited by
- 183
- References
- 53
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 13 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 14 · 2014: 7 · 2013: 21 · 2012: 22
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Breast Cancer Research Foundation
- National Institutes of Health
- National Cancer Institute (CA-42368, R01CA042368)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- CD151, CD49f, breast cancer, basal-like breast cancer, triple-negative breast cancer, tetraspanin-enriched microdomains, laminin-binding integrins, integrin signaling, tumor progression, EGFR, focal adhesion kinase, Rac1, Lck, tumor cell migration and invasion, therapeutic target
- MeSH terms
- Animals, Breast Neoplasms, Cell Adhesion, Cell Movement, Epidermal Growth Factor, Humans, Mice, Nude, Neoplasm Invasiveness, Protein Binding, Tissue Distribution, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Antigens, CD, Gene Expression Regulation, Neoplastic, Disease Progression, Integrin alpha6, Mammary Glands, Human, Mice, Tetraspanin 24
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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