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CD151 Accelerates Breast Cancer by Regulating α6 Integrin Function, Signaling, and Molecular Organization
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Abstract
CD151, a master regulator of laminin-binding integrins (alpha(6)beta(4), alpha(6)beta(1), and alpha(3)beta(1)), assembles these integrins into complexes called tetraspanin-enriched microdomains. CD151 protein expression is elevated in 31% of human breast cancers and is even more elevated in high-grade (40%) and estrogen receptor-negative (45%) subtypes. The latter includes triple-negative (estrogen receptor, progesterone receptor, and HER2 negative) basal-like tumors. CD151 ablation markedly reduced basal-like mammary cell migration, invasion, spreading, and signaling (through FAK, Rac1, and lck) while disrupting epidermal growth factor receptor (EGFR)-alpha(6) integrin collaboration. Underlying these defects, CD151 ablation redistributed alpha(6)beta(4) integrins subcellularly and severed molecular links between integrins and tetraspanin-enriched microdomains. In a prototypical basal-like mammary tumor line, CD151 ablation notably delayed tumor progression in ectopic and orthotopic xenograft models. These results (a) establish that CD151-alpha(6) integrin complexes play a functional role in basal-like mammary tumor progression; (b) emphasize that alpha(6) integrins function via CD151 linkage in the context of tetraspanin-enriched microdomains; and (c) point to potential relevance of CD151 as a high-priority therapeutic target, with relative selectivity (compared with laminin-binding integrins) for pathologic rather than normal physiology.
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“ITGB1 and CD151 are known to be pro-tumorigenic by enhancing cell migration and stromal invasion (Reuter et al., 2009, White et al., 2004, Yang et al., 2008, Zijlstra et al., 2008).”
From Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020) · cites this paper as Yang et al., 2008
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Self-citation
Metadata
- Authors
- Yang, X. H., Richardson, A. L., Torres-Arzayus, M. I., Zhou, P., Sharma, C., Kazarov, A. R., Andzelm, M. M., Strominger, J. L., Brown, M., & Hemler, M. E.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- 2Medical Oncology, and
- ORCID
- Venue
- Cancer Research
- Published
- 2008-05-01
- Volume
- 68
- Issue
- 9
- Pages
- 3204-3213
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC4764302
- OpenAlex
- W2102040455
- Cited by
- 183
- References
- 53
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 13 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 14 · 2014: 7 · 2013: 21 · 2012: 22
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Breast Cancer Research Foundation
- National Institutes of Health
- National Cancer Institute (CA-42368, R01CA042368)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- CD151, CD49f, breast cancer, basal-like breast cancer, triple-negative breast cancer, tetraspanin-enriched microdomains, laminin-binding integrins, integrin signaling, tumor progression, EGFR, focal adhesion kinase, Rac1, Lck, tumor cell migration and invasion, therapeutic target
- MeSH terms
- Animals, Breast Neoplasms, Cell Adhesion, Cell Movement, Epidermal Growth Factor, Humans, Mice, Nude, Neoplasm Invasiveness, Protein Binding, Tissue Distribution, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Antigens, CD, Gene Expression Regulation, Neoplastic, Disease Progression, Integrin alpha6, Mammary Glands, Human, Mice, Tetraspanin 24
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