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A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling
Abstract
Smac mimetic compounds targeting the inhibitor of apoptosis proteins (IAP) baculoviral IAP repeat-3 domain are presumed to reduce the threshold for apoptotic cell death by alleviating caspase-9 repression. We explored this tenet in an unbiased manner by searching for small interfering RNAs that are able to confer resistance to the Smac mimetic compound LBW242. Among the screening hits were multiple components of the tumor necrosis factor α (TNFα) signaling pathway as well as X-linked inhibitor of apoptosis (XIAP) itself. Here, we show that in a subset of highly sensitive tumor cell lines, activity of LBW242 is dependent on TNFα signaling. Mechanistic studies indicate that in this context, XIAP is a positive modulator of TNFα induction whereas cellular inhibitor of apoptosis protein 1 negatively regulates TNFα-mediated apoptosis. [Cancer Res 2007;67(24):11493–8]
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The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases
Eckelman, B. P., & Salvesen, G. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510863200 · Cited by 391
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Metadata
- Authors
- Gaither, A., Porter, D., Yao, Y., Borawski, J., Yang, G., Donovan, J., Sage, D., Slisz, J., Tran, M., Straub, C., Ramsey, T., Iourgenko, V., Huang, A., Chen, Y., Schlegel, R., Labow, M., Fawell, S., Sellers, W. R., & Zawel, L.
- Venue
- Cancer Research
- Published
- 2007-12-15
- Volume
- 67
- Issue
- 24
- Pages
- 11493-11498
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2093475144
- Cited by
- 224
- References
- 1
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Gaither, A., Porter, D., Yao, Y., Borawski, J., Yang, G., Donovan, J., Sage, D., Slisz, J., Tran, M., Straub, C., Ramsey, T., Iourgenko, V., Huang, A., Chen, Y., Schlegel, R., Labow, M., Fawell, S., Sellers, W. R., & Zawel, L. (2007). A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling. Cancer Research. https://doi.org/10.1158/0008-5472.can-07-5173
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