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Cited by 331Cancer Cells and MetastasisImmune cells in cancerAngiogenesis and VEGF in Cancer

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White Adipose Tissue Cells Are Recruited by Experimental Tumors and Promote Cancer Progression in Mouse Models

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Zhang, Yan, Daquinag, Alexes, Traktuev, Dmitry O., Amaya-Manzanares, Felipe, Simmons, Paul J., March, Keith L., Pasqualini, Renata, Arap, Wadih, Kolonin, Mikhail G.·2009·Cancer Research
DOI 10.1158/0008-5472.can-08-3444PMC PMC3857703

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Abstract

The connection between obesity and accelerated cancer progression has been established, but the mediating mechanisms are not well understood. We have shown that stromal cells from white adipose tissue (WAT) cooperate with the endothelium to promote blood vessel formation through the secretion of soluble trophic factors. Here, we hypothesize that WAT directly mediates cancer progression by serving as a source of cells that migrate to tumors and promote neovascularization. To test this hypothesis, we have evaluated the recruitment of WAT-derived cells by tumors and the effect of their engraftment on tumor growth by integrating a transgenic mouse strain engineered for expansion of traceable cells with established allograft and xenograft cancer models. Our studies show that entry of adipose stromal and endothelial cells into systemic circulation leads to their homing to and engraftment into tumor stroma and vasculature, respectively. We show that recruitment of adipose stromal cells by tumors is sufficient to promote tumor growth. Finally, we show that migration of stromal and vascular progenitor cells from WAT grafts to tumors is also associated with acceleration of cancer progression. These results provide a biological insight for the clinical association between obesity and cancer, thus outlining potential avenues for preventive and therapeutic strategies. [Cancer Res 2009;69(12):5259–66]

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Metadata

Authors
Zhang, Y., Daquinag, A., Traktuev, D. O., Amaya-Manzanares, F., Simmons, P. J., March, K. L., Pasqualini, R., Arap, W., & Kolonin, M. G.
Affiliations
  • Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (US)
  • Indiana University Indianapolis (US)
  • 1The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Disease, University of Texas Health Science Center at Houston;
  • The University of Texas MD Anderson Cancer Center (US)
ORCID
Venue
Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2009-06-15
Volume
69
Issue
12
Pages
5259-5266
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
DOI
10.1158/0008-5472.can-08-3444
PMC
PMC3857703
OpenAlex
W2129204158
Cited by
331
References
55
Citations by year
2026: 8 · 2025: 9 · 2024: 21 · 2023: 20 · 2022: 17 · 2021: 22 · 2020: 20 · 2019: 11 · 2018: 15 · 2017: 19 · 2016: 24 · 2015: 30 · 2014: 22 · 2013: 29 · 2012: 23
FWCI
10.50
Type
journal article
Language
en
Open access
Locations
  • Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders
National Cancer Institute (P50CA140388)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
white adipose tissue, tumor microenvironment, adipose stromal cells, tumor cell recruitment, neovascularization, tumor angiogenesis, obesity and cancer, tumor progression, endothelial cells, vascular progenitor cells, cell homing, tumor stroma, transgenic mouse model
MeSH terms
Adipose Tissue, Animals, Disease Models, Animal, Mice, Transgenic, Neoplasms, Experimental, Disease Progression, Mice

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