Cited by 2,332Mesenchymal stem cell researchTissue Engineering and Regenerative MedicineAdipose Tissue and Metabolism

Adipose-derived stem cells for regenerative medicine

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Gimble, Jeffrey M., Katz, Adam J., Bunnell, Bruce A.·2007·Circulation Research

Abstract

The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article.

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Crossref · 10.1161/01.res.0000265074.83288.09

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  • Mesenchymal stem/stromal cells possess pro-regenerative properties: they can differentiate into multiple lineages, home to injury and inflammation, and exert paracrine immunomodulatory, pro-angiogenic, anti-apoptotic and pro-proliferative effects.

    “Mesenchymal stem/stromal cells (MSC) exhibit a set of pro-regenerative features (multi-lineage differentiation capacity, homing to sites of injury and inflammation, and paracrine immunomodulatory, pro-angiogenic, anti-apoptotic and pro-proliferative effects, Figure 1) that make them an attractive candidate for modulation of immune disorders and regenerative therapy approaches [1–3].”

    From Mesenchymal stem cell secretome and regenerative therapy after cancer (2013) · cites this paper as [1]

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Research works printed but not linked: 4

  1. [19]19. Neese RA, Misell LM, Turner S, Chu A, Kim J, Cesar D, Hoh R, Antelo F, Strawford A, McCune JM, Christiansen M, Hellerstein MK. Mea- surement in vivo of proliferation rates of slow turnover cells by 2h2o labeling of the deoxyribose moiety of DNA. Proc Natl Acad Sci U S A. 2002;99:15345-15350.
  2. [20]20. Strawford A, Antelo F, Christiansen M, Hellerstein MK. Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2h2o. Am J Physiol Endocrinol Metab. 2004; 286:E577-E588.
  3. [94]94. Katz AJ, Zang Z, Shang H, Chamberlain AT, Berr SS, Roy RJ, Khurgel M, Epstein FH, French BA. Serial MRI assessment of human adipose- derived stem cells (HASCS) in a murine model of reperfused myocardial infarction. Adipocytes. In press.
  4. [98]98. Hausman GJ, Richardson RL. Adipose tissue angiogenesis. J Anim Sci. 2004;82:925-934.

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Authors
Gimble, J. M., Katz, A. J., & Bunnell, B. A.
Affiliations
Pennington Biomedical Research Center (US)
Venue
Circulation Research
Published
2007-05-11
Volume
100
Issue
9
Pages
1249-1260
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
OpenAlex
W2115062578
Cited by
2,332
References
150
Citations by year
2026: 32 · 2025: 67 · 2024: 61 · 2023: 77 · 2022: 91 · 2021: 105 · 2020: 129 · 2019: 127 · 2018: 160 · 2017: 163 · 2016: 183 · 2015: 172 · 2014: 179 · 2013: 221 · 2012: 160
FWCI
8.06
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Louisiana Gene Therapy Research Consortium
  • Pennington Biomedical Research Foundation
  • Tulane University
  • National Institutes of Health (DK072476, RR00164)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072476)
  • National Center for Research Resources (P51RR000164, RR00164.)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adipose-derived stem cells, regenerative medicine, adipose tissue, stem cell isolation, stem cell characterization, multilineage differentiation, clinical application, preclinical applications
MeSH terms
Adipose Tissue, Cell Differentiation, Cell Separation, Humans, Lipoma, Liposarcoma, Terminology as Topic, Obesity, Immunophenotyping, Cell Lineage, Proteome, Tissue Engineering, Cell Proliferation, Adipogenesis, Adult Stem Cells

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