Adipose-derived stem cells for regenerative medicine
Open accessAbstract
The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article.
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Mesenchymal stem/stromal cells possess pro-regenerative properties: they can differentiate into multiple lineages, home to injury and inflammation, and exert paracrine immunomodulatory, pro-angiogenic, anti-apoptotic and pro-proliferative effects.
“Mesenchymal stem/stromal cells (MSC) exhibit a set of pro-regenerative features (multi-lineage differentiation capacity, homing to sites of injury and inflammation, and paracrine immunomodulatory, pro-angiogenic, anti-apoptotic and pro-proliferative effects, Figure 1) that make them an attractive candidate for modulation of immune disorders and regenerative therapy approaches [1–3].”
From Mesenchymal stem cell secretome and regenerative therapy after cancer (2013) · cites this paper as [1]
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“Since initial reports in the late 1960s (3), multiple independent laboratories have established that stromal cells similar to those identified in bone marrow (4) can be isolated in a reproducible manner from adipose tissue that is either resected as intact tissue or aspirated using tumescent liposuction (5,6).”
BackgroundSelf-citationDefining stem and progenitor cells within adipose tissue
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- Authors
- Gimble, J. M., Katz, A. J., & Bunnell, B. A.
- Affiliations
- Pennington Biomedical Research Center (US)
- Venue
- Circulation Research
- Published
- 2007-05-11
- Volume
- 100
- Issue
- 9
- Pages
- 1249-1260
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC5679280
- OpenAlex
- W2115062578
- Cited by
- 2,332
- References
- 150
- Citations by year
- 2026: 32 · 2025: 67 · 2024: 61 · 2023: 77 · 2022: 91 · 2021: 105 · 2020: 129 · 2019: 127 · 2018: 160 · 2017: 163 · 2016: 183 · 2015: 172 · 2014: 179 · 2013: 221 · 2012: 160
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Louisiana Gene Therapy Research Consortium
- Pennington Biomedical Research Foundation
- Tulane University
- National Institutes of Health (DK072476, RR00164)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072476)
- National Center for Research Resources (P51RR000164, RR00164.)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adipose-derived stem cells, regenerative medicine, adipose tissue, stem cell isolation, stem cell characterization, multilineage differentiation, clinical application, preclinical applications
- MeSH terms
- Adipose Tissue, Cell Differentiation, Cell Separation, Humans, Lipoma, Liposarcoma, Terminology as Topic, Obesity, Immunophenotyping, Cell Lineage, Proteome, Tissue Engineering, Cell Proliferation, Adipogenesis, Adult Stem Cells
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