The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Multipotent CD15+ Cancer Stem Cells in Patched-1 –Deficient Mouse Medulloblastoma
Open accessAbstract
Subpopulations of tumorigenic cells have been identified in many human tumors, although these cells may not be very rare in some types of cancer. Here, we report that medulloblastomas arising from Patched-1–deficient mice contain a subpopulation of cells that show a neural precursor phenotype, clonogenic and multilineage differentiation capacity, activated Hedgehog signaling, wild-type Patched-1 expression, and the ability to initiate tumors following allogeneic orthotopic transplantation. The normal neural stem cell surface antigen CD15 enriches for the in vitro proliferative and in vivo tumorigenic potential from uncultured medulloblastomas, supporting the existence of a cancer stem cell hierarchy in this clinically relevant mouse model of cancer. [Cancer Res 2009;69(11):4682–90]
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Cites
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Cited by
Cancer Stem Cells: Current Status and Evolving Complexities
Visvader, J. E., & Lindeman, G. J. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.007 · Cited by 1,287
Gholamin, S., Mitra, S. S., Feroze, A. H., Liu, J., Kahn, S. A., Zhang, M., Esparza, R., Richard, C., Ramaswamy, V., Remke, M., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2968 · Cited by 426
Kim, J., Aftab, B. T., Tang, J. Y., Kim, D., Lee, A. H., Rezaee, M., Kim, J., Chen, B., King, E. M., Borodovsky, A., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.017 · Cited by 346
Vanner, R. J., Remke, M., Gallo, M., Selvadurai, H. J., Coutinho, F., Lee, L., Kushida, M., Head, R., Morrissy, S., Zhu, X., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.005 · Cited by 305
Self-citationMedulloblastomics revisited: biological and clinical insights from thousands of patients
Hovestadt, V., Ayrault, O., Swartling, F. J., Robinson, G. W., Pfister, S. M., & Northcott, P. A. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0223-8 · Cited by 271
Metadata
- Authors
- Ward, R. J., Lee, L., Graham, K., Satkunendran, T., Yoshikawa, K., Ling, E., Harper, L., Austin, R., Nieuwenhuis, E., Clarke, I. D., Hui, C.-C., & Dirks, P. B.
- Venue
- Cancer Research
- Published
- 2009-06-01
- Volume
- 69
- Issue
- 11
- Pages
- 4682-4690
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W1989715997
- Cited by
- 182
- References
- 1
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Ward, R. J., Lee, L., Graham, K., Satkunendran, T., Yoshikawa, K., Ling, E., Harper, L., Austin, R., Nieuwenhuis, E., Clarke, I. D., Hui, C.-C., & Dirks, P. B. (2009). Multipotent CD15+ Cancer Stem Cells in Patched-1 –Deficient Mouse Medulloblastoma. Cancer Research. https://doi.org/10.1158/0008-5472.can-09-0342
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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