The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma
Open accessAbstract
SUMMARY Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2+ cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism that mirrors a neurogenic program. Rare Sox2+ cells produce rapidly cycling doublecortin+ progenitors that, together with their postmitotic progeny expressing NeuN, comprise tumor bulk. Sox2+ cells are enriched following anti-mitotic chemotherapy and Smoothened inhibition, creating a reservoir for tumor regrowth. Lineage traces from Sox2+ cells increase following treatment, suggesting that this population is responsible for relapse. Targeting Sox2+ cells with the antineoplastic mithramycin abrogated tumor growth. Addressing functional heterogeneity and eliminating Sox2+ cells presents a promising therapeutic paradigm for treatment of sonic hedgehog subgroup medulloblastoma.
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Metadata
- Authors
- Vanner, R. J., Remke, M., Gallo, M., Selvadurai, H. J., Coutinho, F., Lee, L., Kushida, M., Head, R., Morrissy, S., Zhu, X., Aviv, T., Voisin, V., Clarke, I. D., Li, Y., Mungall, A. J., Moore, R. A., Ma, Y., Jones, S. J. M., Marra, M. A., Malkin, D., Northcott, P. A., Kool, M., Pfister, S. M., Bader, G., Hochedlinger, K., Korshunov, A., Taylor, M. D., & Dirks, P. B.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 26
- Issue
- 1
- Pages
- 33-47
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2130264065
- Cited by
- 305
- References
- 56
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma. https://app.cochat.ai/papers/10.1016/j.ccr.2014.05.005
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- Vanner, R. J., Remke, M., Gallo, M., Selvadurai, H. J., Coutinho, F., Lee, L., Kushida, M., Head, R., Morrissy, S., Zhu, X., Aviv, T., Voisin, V., Clarke, I. D., Li, Y., Mungall, A. J., Moore, R. A., Ma, Y., Jones, S. J. M., Marra, M. A., . . . Dirks, P. B. (2014). Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma. Cancer Cell. https://doi.org/10.1016/j.ccr.2014.05.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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