The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation
Open accessAbstract
Autophagy that is induced by starvation or cellular stress can enable cancer cell survival by sustaining energy homeostasis and eliminating damaged organelles and proteins. In response to stress, cancer cells have been reported to accumulate the protein p62/SQSTM1 (p62), but its role in the regulation of autophagy is controversial. Here, we report that the plant phytoalexin resveratrol (RSV) triggers autophagy in imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia (CML) cells via JNK-dependent accumulation of p62. JNK inhibition or p62 knockdown prevented RSV-mediated autophagy and antileukemic effects. RSV also stimulated AMPK, thereby inhibiting the mTOR pathway. AMPK knockdown or mTOR overexpression impaired RSV-induced autophagy but not JNK activation. Lastly, p62 expression and autophagy in CD34+ progenitors from patients with CML was induced by RSV, and disrupting autophagy protected CD34+ CML cells from RSV-mediated cell death. We concluded that RSV triggered autophagic cell death in CML cells via both JNK-mediated p62 overexpression and AMPK activation. Our findings show that the JNK and AMPK pathways can cooperate to eliminate CML cells via autophagy. Cancer Res; 70(3); 1042–52
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Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
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Sahra, I. B., Laurent, K., Loubat, A., Giorgetti-Peraldi, S., Colosetti, P., Auberger, P., Tanti, J. F., Le Marchand-Brustel, Y., & Bost, F. (2008) · Oncogene · doi:10.1038/sj.onc.1211024 · Cited by 861
Self-citationResveratrol stimulates AMP kinase activity in neurons
Dasgupta, B., & Milbrandt, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610068104 · Cited by 723
The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis
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Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells
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Cited by
Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
Wu, Y., Li, X., Zhu, J. X., Xie, W., Le, W., Fan, Z., Jankovic, J., & Pan, T. (2011) · Neurosignals · doi:10.1159/000328516 · Cited by 492
MAPK/JNK signalling: a potential autophagy regulation pathway
Zhou, Y.-Y., Li, Y., Jiang, W.-Q., & Zhou, L.-F. (2015) · Bioscience Reports · doi:10.1042/bsr20140141 · Cited by 444
Sphingolipids: regulators of crosstalk between apoptosis and autophagy
Young, M. M., Kester, M., & Wang, H.-G. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r031278 · Cited by 329
Targeting autophagy using natural compounds for cancer prevention and therapy
Deng, S., Shanmugam, M. K., Kumar, A. P., Yap, C. T., Sethi, G., & Bishayee, A. (2019) · Cancer · doi:10.1002/cncr.31978 · Cited by 320
Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis
Gali-Muhtasib, H., Hmadi, R., Kareh, M., Tohme, R., & Darwiche, N. (2015) · Apoptosis · doi:10.1007/s10495-015-1169-2 · Cited by 293
Metadata
- Authors
- Puissant, A., Robert, G., Fenouille, N., Luciano, F., Cassuto, J.-P., Raynaud, S., & Auberger, P.
- Venue
- Cancer Research
- Published
- 2010-01-31
- Volume
- 70
- Issue
- 3
- Pages
- 1042-1052
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2143017085
- Cited by
- 374
- References
- 7
- FWCI
- 22.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Puissant, A., Robert, G., Fenouille, N., Luciano, F., Cassuto, J.-P., Raynaud, S., & Auberger, P. (2010). Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation. Cancer Research. https://doi.org/10.1158/0008-5472.can-09-3537
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