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Detection of Circulating Tumor Cells in Human Peripheral Blood Using Surface-Enhanced Raman Scattering Nanoparticles
Open accessAbstract
The detection and characterization of circulating tumor cells (CTC) holds great promise for personalizing medicine and optimizing systemic therapy. However, low specificity, low sensitivity, and the time consuming nature of current approaches have impeded clinical adoption. Here we report a new method using surface-enhanced Raman spectroscopy (SERS) to directly measure targeted CTCs in the presence of white blood cells. SERS nanoparticles with epidermal growth factor peptide as a targeting ligand have successfully identified CTCs in the peripheral blood of 19 patients with squamous cell carcinoma of the head and neck (SCCHN), with a range of 1 to 720 CTCs per milliliter of whole blood. Our technique may provide an important new clinical tool for management of patients with SCCHN and other cancers. Cancer Res; 71(5); 1526–32. ©2011 AACR.
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In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
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Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800668 · Cited by 1,617
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Self-citationSERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging
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Shen, Z., Wu, A., & Chen, X. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00803h · Cited by 433
Metadata
- Authors
- Wang, X., Qian, X., Beitler, J. J., Chen, Z. G., Khuri, F. R., Lewis, M. M., Shin, H. J. C., Nie, S., & Shin, D. M.
- Venue
- Cancer Research
- Published
- 2011-03-01
- Volume
- 71
- Issue
- 5
- Pages
- 1526-1532
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2168309066
- Cited by
- 358
- References
- 2
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, X., Qian, X., Beitler, J. J., Chen, Z. G., Khuri, F. R., Lewis, M. M., Shin, H. J. C., Nie, S., & Shin, D. M. (2011). Detection of Circulating Tumor Cells in Human Peripheral Blood Using Surface-Enhanced Raman Scattering Nanoparticles. Cancer Research. https://doi.org/10.1158/0008-5472.can-10-3069
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