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Effects of Photoacoustic Imaging and Photothermal Ablation Therapy Mediated by Targeted Hollow Gold Nanospheres in an Orthotopic Mouse Xenograft Model of Glioma
Open accessAbstract
Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously to image and treat cancers. For example, hollow gold nanospheres (HAuNS) have been shown to generate intense photoacoustic signals and induce efficient photothermal ablation (PTA) therapy. In this study, we used photoacoustic tomography, a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma. Mice were then treated with near-infrared laser, which elevated tumor temperature by 20.7°C. We found that PTA treatment significantly prolonged the survival of tumor-bearing mice. Taken together, these results show the feasibility of using a single nanostructure for image-guided local tumor PTA therapy with photoacoustic molecular imaging. Cancer Res; 71(19); 6116–21. ©2011 AACR.
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Citations
Cited by
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Riley, R. S., & Day, E. S. (2017) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1449 · Cited by 801
Wang, Y., Wang, K., Zhao, J., Liu, X., Bu, J., Yan, X., & Huang, R. (2013) · Journal of the American Chemical Society · doi:10.1021/ja312221g · Cited by 527
Jin, C. S., Lovell, J. F., Chen, J., & Zheng, G. (2013) · ACS Nano · doi:10.1021/nn3058642 · Cited by 414
Multifunctional nanoparticles for brain tumor imaging and therapy
Cheng, Y., Morshed, R. A., Auffinger, B., Tobias, A. L., & Lesniak, M. S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.006 · Cited by 349
Metadata
- Authors
- Lu, W., Melancon, M. P., Xiong, C., Huang, Q., Elliott, A., Song, S., Zhang, R., Flores, L. G., Gelovani, J. G., Wang, L. V., Ku, G., Stafford, R. J., & Li, C.
- Venue
- Cancer Research
- Published
- 2011-09-29
- Volume
- 71
- Issue
- 19
- Pages
- 6116-6121
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2135803705
- Cited by
- 205
- References
- 0
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Lu, W., Melancon, M. P., Xiong, C., Huang, Q., Elliott, A., Song, S., Zhang, R., Flores, L. G., Gelovani, J. G., Wang, L. V., Ku, G., Stafford, R. J., & Li, C. (2011). Effects of Photoacoustic Imaging and Photothermal Ablation Therapy Mediated by Targeted Hollow Gold Nanospheres in an Orthotopic Mouse Xenograft Model of Glioma. Cancer Research. https://doi.org/10.1158/0008-5472.can-10-4557
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