The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma
Abstract
Current therapy of malignant glioma in clinic is unsatisfactory with poor patient compliance due to low therapeutic efficiency and strong systemic side effects. Herein, we combined chemo-photothermal targeted therapy of glioma within one novel multifunctional drug delivery system. A targeting peptide (IP)-modified mesoporous silica-coated graphene nanosheet (GSPI) was successfully synthesized and characterized, and first introduced to the drug delivery field. A doxorubicin (DOX)-loaded GSPI-based system (GSPID) showed heat-stimulative, pH-responsive, and sustained release properties. Cytotoxicity experiments demonstrated that combined therapy mediated the highest rate of death of glioma cells compared to that of single chemotherapy or photothermal therapy. Furthermore, the IP modification could significantly enhance the accumulation of GSPID within glioma cells. These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.
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Cites
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
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Graphene-based smart materials
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25th Anniversary Article: Hybrid Nanostructures Based on Two‐Dimensional Nanomaterials
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Zeng, X., Luo, M., Liu, G., Wang, X., Tao, W., Lin, Y., Ji, X., Nie, L., & Mei, L. (2018) · Advanced Science · doi:10.1002/advs.201800510 · Cited by 598
Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights
Vallet-Regí, M., Colilla, M., Izquierdo-Barba, I., & Manzano, M. (2017) · Molecules · doi:10.3390/molecules23010047 · Cited by 538
Metadata
- Authors
- Wang, Y., Wang, K., Zhao, J., Liu, X., Bu, J., Yan, X., & Huang, R.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-03-15
- Volume
- 135
- Issue
- 12
- Pages
- 4799-4804
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2329969567
- Cited by
- 527
- References
- 37
- FWCI
- 33.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, Y., Wang, K., Zhao, J., Liu, X., Bu, J., Yan, X., & Huang, R. (2013). Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma. Journal of the American Chemical Society. https://doi.org/10.1021/ja312221g
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