The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
TRPM7 Is Required for Breast Tumor Cell Metastasis
Abstract
TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether TRPM7 activity contributes to cancer progression has not been established. Here we report that high levels of TRPM7 expression independently predict poor outcome in breast cancer patients and that it is functionally required for metastasis formation in a mouse xenograft model of human breast cancer. Mechanistic investigation revealed that TRPM7 regulated myosin II–based cellular tension, thereby modifying focal adhesion number, cell–cell adhesion and polarized cell movement. Our findings therefore suggest that TRPM7 is part of a mechanosensory complex adopted by cancer cells to drive metastasis formation. Cancer Res; 72(16); 4250–61. ©2012 AACR.
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Jaalouk, D. E., & Lammerding, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2597 · Cited by 1,396
Calcium flickers steer cell migration
Wei, C., Wang, X., Chen, M., Ouyang, K., Song, L.-S., & Cheng, H. (2009) · Nature · doi:10.1038/nature07577 · Cited by 611
Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow
Oancea, E., Wolfe, J. T., & Clapham, D. E. (2006) · Circulation Research · doi:10.1161/01.res.0000200179.29375.cc · Cited by 249
Cited by
Nilius, B., & Szallasi, A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008268 · Cited by 506
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Davis, F. M., Azimi, I., Faville, R. A., Peters, A. A., Jalink, K., Putney, J. W., Goodhill, G. J., Thompson, E. W., Roberts-Thomson, S. J., & Monteith, G. R. (2014) · Oncogene · doi:10.1038/onc.2013.187 · Cited by 333
Self-citationCancer as a channelopathy: ion channels and pumps in tumor development and progression
Litan, A., & Langhans, S. A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00086 · Cited by 276
Ion channel expression as promising cancer biomarker
Lastraioli, E., Iorio, J., & Arcangeli, A. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.12.016 · Cited by 187
Metadata
- Authors
- Middelbeek, J., Kuipers, A. J., Henneman, L., Visser, D., Eidhof, I., van Horssen, R., Wieringa, B., Canisius, S. V., Zwart, W., Wessels, L. F., Sweep, F. C. G. J., Bult, P., Span, P. N., van Leeuwen, F. N., & Jalink, K.
- Venue
- Cancer Research
- Published
- 2012-08-14
- Volume
- 72
- Issue
- 16
- Pages
- 4250-4261
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2132264780
- Cited by
- 210
- References
- 3
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Middelbeek, J., Kuipers, A. J., Henneman, L., Visser, D., Eidhof, I., van Horssen, R., Wieringa, B., Canisius, S. V., Zwart, W., Wessels, L. F., Sweep, F. C. G. J., Bult, P., Span, P. N., van Leeuwen, F. N., & Jalink, K. (2012). TRPM7 Is Required for Breast Tumor Cell Metastasis. Cancer Research. https://doi.org/10.1158/0008-5472.can-11-3863
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