The DOI matches its Crossref record; 47 of the 49 references it cites were found in a registry or an index.
JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells
Published version of a preprint
Abstract
Interleukin (IL)-6 overexpression and constitutive STAT3 activation occur in many cancers, including prostate cancer. However, their contribution to prostate stem and progenitor cells has not been explored. In this study, we show that stem-like cells from patients with prostate cancer secrete higher levels of IL-6 than their counterparts in non-neoplastic prostate. Tumor grade did not influence the levels of expression or secretion. Stem-like and progenitor cells expressed the IL-6 receptor gp80 with concomitant expression of pSTAT3. Blockade of activated STAT3, by either anti-IL-6 antibody siltuximab (CNTO 328) or LLL12, a specific pSTAT3 inhibitor, suppressed the clonogenicity of the stem-like cells in patients with high-grade disease. In a murine xenograft model used to determine the in vivo effects of pSTAT3 suppression, LLL12 treatment effectively abolished outgrowth of a patient-derived castrate-resistant tumor. Our results indicate that the most primitive cells in prostate cancer require pSTAT3 for survival, rationalizing STAT3 as a therapeutic target to treat advanced prostate cancer. Cancer Res; 73(16); 5288–98. ©2013 AACR.
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“The IL-6/JAK/STAT3 signalling pathway plays an important role in human malignancies such as CRC.12,15,46,48,49”
From PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells (2022) · cites this paper as [49]
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Cites
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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
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Identification of Pancreatic Cancer Stem Cells
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Self-citationProspective Identification of Tumorigenic Prostate Cancer Stem Cells
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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
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Revisiting STAT3 signalling in cancer: new and unexpected biological functions
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Tackling the cancer stem cells — what challenges do they pose?
Pattabiraman, D. R., & Weinberg, R. A. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4253 · Cited by 1,013
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
Taniguchi, K., & Karin, M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.001 · Cited by 724
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Chen, X., Yao, Q., Gu, X., Shi, Q., Yuan, X., Chu, Q., Bao, Z., Lu, J., & Li, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01468-7 · Cited by 797
Cancer stem cells: advances in knowledge and implications for cancer therapy
Chu, X., Tian, W., Ning, J., Xiao, G., Zhou, Y., Wang, Z., Zhai, Z., Tanzhu, G., Yang, J., & Zhou, R. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01851-y · Cited by 656
Metadata
- Authors
- Kroon, P., Berry, P. A., Stower, M. J., Rodrigues, G., Mann, V. M., Simms, M., Bhasin, D., Chettiar, S., Li, C., Li, P.-K., Maitland, N. J., & Collins, A. T.
- Affiliations
- York Hospital (GB)
- Venue
- Cancer Research
- Published
- 2013-08-13
- Volume
- 73
- Issue
- 16
- Pages
- 5288-5298
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2069303628
- Cited by
- 175
- References
- 49
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 10 · 2023: 13 · 2022: 13 · 2021: 12 · 2020: 10 · 2019: 13 · 2018: 13 · 2017: 15 · 2016: 19 · 2015: 26 · 2014: 18 · 2013: 1
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Prostate Cancer UK (PG12-01)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- prostate cancer, cancer stem-like cells, STAT3 activation, interleukin-6, siltuximab, tumor initiation, castration-resistant prostate cancer, therapeutic target
- MeSH terms
- Aged, Aged, 80 and over, Animals, Anthraquinones, Antibodies, Monoclonal, Humans, Male, Middle Aged, Sulfonamides, Neoplastic Stem Cells, Interleukin-6, Receptors, Interleukin-6, Cell Line, Tumor, STAT3 Transcription Factor, Mice, Janus Kinases, Prostatic Neoplasms, Castration-Resistant
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