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Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
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Abstract
The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of HGG that arise in the brainstem almost exclusively in children. Genome-wide analyses of copy number imbalances previously showed that platelet-derived growth factor receptor α (PDGFRA) is the most frequent target of focal amplification in pediatric HGGs, including DIPGs. To determine whether PDGFRA is also targeted by more subtle mutations missed by copy number analysis, we sequenced all PDGFRA coding exons from a cohort of pediatric HGGs. Somatic-activating mutations were identified in 14.4% (13 of 90) of nonbrainstem pediatric HGGs and 4.7% (2 of 43) of DIPGs, including missense mutations and in-frame deletions and insertions not previously described. Forty percent of tumors with mutation showed concurrent amplification, whereas 60% carried heterozygous mutations. Six different mutations impacting different domains all resulted in ligand-independent receptor activation that was blocked by small molecule inhibitors of PDGFR. Expression of mutants in p53-null primary mouse astrocytes conferred a proliferative advantage in vitro and generated HGGs in vivo with complete penetrance when implanted into brain. The gene expression signatures of these murine HGGs reflected the spectrum of human diffuse HGGs. PDGFRA intragenic deletion of exons 8 and 9 were previously shown in adult HGG, but were not detected in 83 nonbrainstem pediatric HGG and 57 DIPGs. Thus, a distinct spectrum of mutations confers constitutive receptor activation and oncogenic activity to PDGFRα in childhood HGG.
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“suggesting that, unlike WT PDGFRA, PDGFRAD842V does not require H3.3K27M to drive tumorigenesis in vivo”
From H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas (2017) · cites this paper as Paugh et al., 2013
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Cites
The 2007 WHO Classification of Tumours of the Central Nervous System
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,656
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735
Verhaak, R. G. W., Hoadley, K. A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M. D., Miller, C. R., Ding, L., Golub, T., Mesirov, J. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.020 · Cited by 7,575
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors
Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., et al. (1998) · Science · doi:10.1126/science.279.5350.577 · Cited by 4,487
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
Barbie, D. A., Tamayo, P., Boehm, J. S., Kim, S. Y., Moody, S. E., Dunn, I. F., Schinzel, A. C., Sandy, P., Meylan, E., Scholl, C., et al. (2009) · Nature · doi:10.1038/nature08460 · Cited by 3,922
PHILLIPS, H. S., Kharbanda, S., Chen, R., Forrest, W. F., Soriano, R. H., Wu, T. D., Misra, A., Nigro, J. M., Colman, H., Soroceanu, L., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.02.019 · Cited by 3,197
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Schwartzentruber, J., Korshunov, A., Liu, X.-Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D.-A. K., Tönjes, M., et al. (2012) · Nature · doi:10.1038/nature10833 · Cited by 2,631
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Heldin, C. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-97 · Cited by 536
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Mount, C., Majzner, R. G., Sundaresh, S., Arnold, E. P., Kadapakkam, M., Haile, S. T., Labanieh, L., Hulleman, E., Woo, P. J., Rietberg, S. P., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0006-x · Cited by 522
Qaddoumi, I. A., Orisme, W., Wen, J., Santiago, T., Gupta, K., Dalton, J., Tang, B., Haupfear, K., Punchihewa, C., Easton, J. B., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1539-z · Cited by 411
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Jones, C., Karajannis, M. A., Jones, D., Kieran, M. W., Monje, M., Baker, S. J., Becher, O. J., Cho, Y., Gupta, N. M., Hawkins, C. E., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now101 · Cited by 372
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Larson, J. D., Kasper, L. H., Paugh, B. S., Jin, H., Wu, G., Kwon, C.-H., Fan, Y., Shaw, T. I., Silveira, A. B., Qu, C., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.11.015 · Cited by 312
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Zong, H., Parada, L. F., & Baker, S. J. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020610 · Cited by 281
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Tomuleasa, C., Tigu, A.-B., Munteanu, R. A., Moldovan, C. S., Kegyes, D., Onaciu, A., Gulei, D., Ghiaur, G., Einsele, H., & Croce, C. M. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01899-w · Cited by 307
Pathania, M., De Jay, N., Maestro, N., Harutyunyan, A. S., Nitarska, J., Pahlavan, P., Henderson, S., Mikael, L. G., Richard-Londt, A., Zhang, Y., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.09.014 · Cited by 264
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Puget, S., Beccaria, K., Blauwblomme, T., Roujeau, T., James, S., Grill, J., Zérah, M., Varlet, P., & Sainte‐Rose, C. (2015) · Child s Nervous System · doi:10.1007/s00381-015-2832-1 · Cited by 217
Hoffman, L. M., DeWire, M. D., Ryall, S. T., Buczkowicz, P., Leach, J., Miles, L., Ramani, A. K., Brudno, M., Kumar, S. S., Drissi, R., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0269-0 · Cited by 198
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Cordero, F. J., Huang, Z., Grenier, C., He, X., Hu, G., McLendon, R. E., Murphy, S. K., Hashizume, R., & Becher, O. J. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0389 · Cited by 157
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Gajjar, A. J., Pfister, S. M., Taylor, M. D., & Gilbertson, R. J. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0833 · Cited by 150
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Guérit, E. M., Arts, F. A., Dachy, G., Boulouadnine, B., & Demoulin, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03753-y · Cited by 146
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Johung, T., & Monje, M. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160509123229 · Cited by 131
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Allen, C. E., Laetsch, T. W., Mody, R. J., Irwin, M. S., Lim, M. S., Adamson, P. C., Seibel, N. L., Parsons, D. W., Cho, Y., & Janeway, K. A. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw274 · Cited by 115
Müller, S., Liu, S. J., Lullo, E. D., Malatesta, M., Pollen, A. A., Nowakowski, T. J., Kohanbash, G., Aghi, M. K., Kriegstein, A. R., Lim, D. A., et al. (2016) · Molecular Systems Biology · doi:10.15252/msb.20166969 · Cited by 102
Self-citationPDGF Receptors in Tumor Biology: Prognostic and Predictive Potential
Paulsson, J., Ehnman, M., & Östman, A. (2014) · Future Oncology · doi:10.2217/fon.14.83 · Cited by 96
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Lapin, D. H., Tsoli, M., & Ziegler, D. S. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00057 · Cited by 84
Al-Halabi, K., Stichel, D., Sievers, P., Peterziel, H., Sommerkamp, A. C., Sturm, D., Wittmann, A., Sill, M., Jäger, N., Beck, P., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02354-8 · Cited by 89
Self-citationPagès, M., Rotem, D., Gydush, G., Reed, S. C., Rhoades, J., Ha, G., Lo, C., Fleharty, M., Duran, M., Jones, R. E., et al. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noab299 · Cited by 90
Haase, S., Banerjee, K., Mujeeb, A., Hartlage, C. S., Núñez, F. M., Núñez, F. J., Alghamri, M. S., Kadiyala, P., Carney, S. V., Barissi, M. N., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci154229 · Cited by 89
Findlay, I. J., Iuliis, G. N. D., Duchatel, R. J., Jackson, E. R., Vitanza, N. A., Cain, J. E., Waszak, S. M., & Dun, M. D. (2021) · Oncogene · doi:10.1038/s41388-021-02102-y · Cited by 86
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Coniglio, S. J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00313 · Cited by 83
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Ip, C. K. M., Ng, P. K., Jeong, K. J., Shao, S. H., Ju, Z., Leonard, P. G., Hua, X., Vellano, C. P., Woessner, R. D., Sahni, N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06949-w · Cited by 77
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Price, G. A., Bouras, A., Hambardzumyan, D., & Hadjipanayis, C. G. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103453 · Cited by 79
Northcott, P. A., Pfister, S. M., & Jones, D. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(14)71206-9 · Cited by 80
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Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C. M., Chung, A., Crabtree, D., Cordero, F. J., Singh, R. B., Spasojević, I., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118926 · Cited by 77
Truffaux, N., Philippe, C., Paulsson, J., Andreiuolo, F. D. M., Guerrini‐Rousseau, L., Cornilleau, G., Dret, L. L., Richon, C., Lacroix, L., Puget, S., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou330 · Cited by 76
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Solomon, D. A., Korshunov, A., Sill, M., Jones, D., Kool, M., Pfister, S. M., Fan, X., Bannykh, S., Hu, J. L., Danielpour, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1883-2 · Cited by 69
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He, C., Xu, K., Zhu, X., Dunphy, P. S., Gudenas, B. L., Lin, W., Twarog, N. R., Hover, L. D., Kwon, C.-H., Kasper, L. H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24168-8 · Cited by 67
Self-citationPeng, G., Wang, Y., Ge, P., Bailey, C. M., Zhang, P., Zhang, D., Meng, Z., Qi, C., Chen, Q., Chen, J., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02082-7 · Cited by 63
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Chiang, J., & Ellison, D. W. (2016) · The Journal of Pathology · doi:10.1002/path.4813 · Cited by 63
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Navis, A. C., van Lith, S. A. M., van Duijnhoven, S. M. J., de Pooter, M., Yetkin-Arik, B., Wesseling, P., Hendriks, W. J. A. J., Venselaar, H., Timmer, M., van Cleef, P., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1420-5 · Cited by 46
Therapeutic targeting of platelet-derived growth factor receptors in solid tumors
Ehnman, M., & Östman, A. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.847086 · Cited by 45
Oliveira, R. J. D. S., Silva, V. A. O., Martinho, O., Cruvinel‐Carloni, A., Melendez, M. E., Rosa, M. N., de Paula, F. E., Viana, L. D. S., Carvalho, A. L., & Reis, R. M. (2016) · Cellular Oncology · doi:10.1007/s13402-016-0270-z · Cited by 45
Self-citationTargeting the VEGF and PDGF signaling pathway in glioblastoma treatment.
Popescu, A. M., Alexandru, O., Brindusa, C., Purcaru, Ş. O., Tache, D. E., Tătăranu, L. G., Taisescu, C. I., & Dricu, A. (2015) · PubMed Central · Cited by 45
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Jenseit, A., Camgöz, A., Pfister, S. M., & Kool, M. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02382-4 · Cited by 43
Ahsan, S., Raabe, E. H., Haffner, M. C., Vaghasia, A. M., Warren, K. E., Quezado, M., Ballester, L. Y., Nazarian, J., Eberhart, C. G., & Rodríguez, F. J. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-59 · Cited by 42
Molecular Genetics and Targeted Therapies for Paediatric High-grade Glioma
Rallis, K. S., George, A. M., Wozniak, A. M., Bigogno, C. M., Chow, B., HANRAHAN, J. G., & Sideris, M. C. (2022) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20328 · Cited by 42
Diffuse intrinsic pontine glioma (DIPG): A review of current and emerging treatment strategies
Weisbrod, L. J., Anand, T., Vengoji, R., Shonka, N., Jain, M., Ho, W. S., Batra, S. K., & Salehi, A. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216876 · Cited by 44
Phi, J. H., Park, A. K., Lee, S., Choi, S. A., Baek, I.-P., Kim, P., Kim, E.-H., Park, H. C., Kim, B. C., Bhak, J., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1845-8 · Cited by 39
Invited Review: Emerging functions of histone H3 mutations in paediatric diffuse high‐grade gliomas
Kasper, L. H., & Baker, S. J. (2019) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12591 · Cited by 40
Self-citationKaye, E. C., Baker, J. N., & Broniscer, A. (2014) · CNS Oncology · doi:10.2217/cns.14.47 · Cited by 38
Self-citationAricò, A., Ferraresso, S., Bresolin, S., Marconato, L., Comazzi, S., Kronnie, G. T., & Aresu, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111817 · Cited by 37
Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies
Meel, M. H., Sewing, A. C. P., Waranecki, P., Metselaar, D. S., Wedekind, L. E., Köster, J., van Vuurden, D. G., Kaspers, G. J. L., & Hulleman, E. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.09.032 · Cited by 38
Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities
Glod, J. W., Rahme, G. J., Kaur, H., Raabe, E. H., Hwang, E. I., & Israel, M. A. (2016) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000551 · Cited by 36
Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas
Juratli, T. A., Qin, N., Cahill, D. P., & Filbin, M. G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.08.006 · Cited by 36
Hemispherical Pediatric High-Grade Glioma: Molecular Basis and Therapeutic Opportunities
Haase, S., Núñez, F. M., Gauss, J. C., Thompson, S., Brumley, E. K., Lowenstein, P. R., & Castro, M. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249654 · Cited by 35
Schwark, K., Messinger, D., Cummings, J. R., Bradin, J., Kawakibi, A. R., Babila, C. M., Lyons, S., Ji, S., Cartaxo, R. T., Kong, S., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.922928 · Cited by 35
McNicholas, M., Cola, A. D., Bashardanesh, Z., Foss, A., Lloyd, C. B., Hébert, S., Faury, D., Andrade, A. F., Jabado, N., Kleinman, C. L., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0004 · Cited by 32
Misuraca, K. L., Barton, K. L., Chung, A., Diaz, A. K., Conway, S. J., Corcoran, D. L., Baker, S. J., & Becher, O. J. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0134-6 · Cited by 33
Self-citationMolecular characteristics of pediatric high-grade gliomas
Chamdine, O., & Gajjar, A. J. (2014) · CNS Oncology · doi:10.2217/cns.14.43 · Cited by 36
Casanova, M., Bautista, F. J., Campbell-Hewson, Q., Makin, G., Marshall, L. V., Verschuur, A. C., Cañete, A., Corradini, N., Ploeger, B. A., Brennan, B. J., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0257 · Cited by 32
Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma
Georgescu, M., Islam, M. Z., Li, Y., Circu, M. L., Traylor, J. G., Notarianni, C., Kline, C., & Burns, D. K. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00992-9 · Cited by 32
Das, K. K., & Kumar, R. (2017) · Codon Publications eBooks · doi:10.15586/codon.glioblastoma.2017.ch15 · Cited by 30
Reactive Astrocytes in Glioma: Emerging Opportunities and Challenges
Wu, J., Li, R., Wang, J., Zhu, H., Ma, Y., You, C., & Shu, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072907 · Cited by 35
Advanced Magnetic Resonance Imaging in Pediatric Glioblastomas
Gonçalves, F. G., Viaene, A. N., & Vossough, A. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.733323 · Cited by 30
Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers
Fleischer, L. M., Somaiya, R. D., & Miller, G. M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00683 · Cited by 32
Geoerger, B., Morland, B. J., Jiménez, I., Frappaz, D., Pearson, A. D. J., Vassal, G., Maeda, P., Kincaide, J., Mueller, U. W., Schlief, S., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.05.023 · Cited by 29
Funato, K., & Tabar, V. S. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050143 · Cited by 30
Roles of PDGF/PDGFR signaling in various organs
Jung, S., Kang, D., & Ko, E. (2024) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.24.309 · Cited by 31
Metadata
- Authors
- Paugh, B. S., Zhu, X., Qu, C., Endersby, R., Diaz, A. K., Zhang, J., Bax, D. A., Carvalho, D., Reis, R. M., Onar-Thomas, A., Broniscer, A., Wetmore, C., Zhang, J., Jones, C., Ellison, D. W., & Baker, S. J.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Authors' Affiliations: Departments of 1Developmental Neurobiology, 2Computational Biology, 3Biostatistics, 4Oncology, and 5Pathology, St. Jude Children's Research Hospital; 6Interdisciplinary Biomedical Science Program, University of Tennessee Health Sciences Center, Memphis, Tennessee; 7Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia; 8Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom; and 9Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil
- Corresponding author
- Baker, Suzanne J.
- ORCID
- Venue
- Cancer Research
- Published
- 2013-10-14
- Volume
- 73
- Issue
- 20
- Pages
- 6219-6229
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC3800209
- OpenAlex
- W2124839835
- Cited by
- 235
- References
- 58
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 17 · 2023: 14 · 2022: 23 · 2021: 25 · 2020: 14 · 2019: 14 · 2018: 22 · 2017: 26 · 2016: 17 · 2015: 14 · 2014: 23 · 2013: 3
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- V Foundation for Cancer Research
- Cure Starts Now Foundation
- American Lebanese Syrian Associated Charities
- Arog Pharmaceuticals
- Brain Tumour Charity
- National Institutes of Health
- National Cancer Institute (R01CA135554, P01CA096832, P30CA021765)
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Tumor Research and Treatment
- Keywords
- PDGFRA mutation, pediatric high-grade glioma, diffuse intrinsic pontine glioma, somatic activating mutations, ligand-independent receptor activation, PDGFR inhibitors, oncogenic receptor tyrosine kinase, exon deletion, brainstem glioma
- MeSH terms
- Adolescent, Animals, Brain Neoplasms, Child, Child, Preschool, Glioma, Humans, Mutation, Receptor, Platelet-Derived Growth Factor alpha, Gene Expression Profiling, Mice, Genome-Wide Association Study
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