Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
Open accessAbstract
Paediatric high-grade glioma and diffuse intrinsic pontine glioma are rare, incurable childhood brain tumours with differing biology to adult cancers.We collated data from 157 unpublished cases and 20 publically available datasets in an integrated analysis comprising 1067 unique patients across all anatomical compartments of the CNS.Distinct clinicopathological and molecular subgroups are defined by specific histone mutations, with novel co-segregating mutations identified including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M.Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumours.Genomic aberrations decrease with age, highlighting the infant population as biologically and clinically distinct.Across the whole cohort, we identify novel pathway dysregulation in small subsets of tumours, further defining the molecular diversity of the disease, opening up novel avenues for biological study and providing a basis for functionally-defined future treatment stratification.
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Several studies have shown that the loss of H3K27 trimethylation leads to major gene expression changes that are accompanied by a concomitant gain of acetylation at H3K27.
“Several studies have shown that the loss of H3K27 trimethylation leads to major gene expression changes that are accompanied by a concomitant gain of acetylation at H3K27 107,111,114 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [111]
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
Louis, D. N., Perry, A., Reifenberger, G., von Deimling, A., Figarella‐Branger, D., Cavenee, W. K., Ohgaki, H., Wiestler, O. D., Kleihues, P., & Ellison, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1545-1 · Cited by 15,703 · see citing works
Ostrom, Q. T., Gittleman, H. R., Farah, P., Ondracek, A., Chen, Y., Wolinsky, Y., Stroup, N. E., Kruchko, C. A., & Barnholtz‐Sloan, J. S. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not151 · Cited by 12,049 · see citing works
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Schwartzentruber, J., Korshunov, A., Liu, X.-Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D.-A. K., Tönjes, M., et al. (2012) · Nature · doi:10.1038/nature10833 · Cited by 2,631 · see citing works
Self-citationCeccarelli, M., Barthel, F. P., Malta, T. M., Sabedot, T. S., Salama, S. R., Murray, B. A., Morozova, O., Newton, Y., Radenbaugh, A., Pagnotta, S. M., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.028 · Cited by 2,178 · see citing works
Ostrom, Q. T., Gittleman, H. R., Fulop, J., Liu, M. B., Blanda, R., Kromer, C. M., Wolinsky, Y., Kruchko, C. A., & Barnholtz‐Sloan, J. S. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov189 · Cited by 2,142 · see citing works
Sturm, D., Witt, H., Hovestadt, V., Khuong-Quang, D.-A., Jones, D. T. W., Konermann, C., Pfaff, E., Tönjes, M., Sill, M., Bender, S., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.024 · Cited by 1,828 · see citing works
Self-citationSt. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project (2012) · Nature Genetics · doi:10.1038/ng.1102 · Cited by 1,724 · see citing works
Wu, G., Li, Y., Qu, C., Chen, X. '., Edmonson, M. N., Ma, X., Nagahawatte, P., Hedlund, E., Rusch, M., Huether, R., et al. (2014) · Nature Genetics · doi:10.1038/ng.2938 · Cited by 1,101 · see citing works
Self-citationKhuong-Quang, D.-A., Buczkowicz, P., Rakopoulos, P., Liu, X.-Y., Fontebasso, A. M., Bouffet, E., Bartels, U., Albrecht, S., Schwartzentruber, J., Letourneau, L., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0998-0 · Cited by 1,028 · see citing works
Self-citationNeuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion
Venkatesh, H. S., Johung, T., Caretti, V., Noll, A., Tang, Y., Nagaraja, S., Gibson, E. M., Mount, C., Polepalli, J. S., Mitra, S. S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.012 · Cited by 974 · see citing works
Self-citationWelcker, M., Orian, A., Jin, J., Grim, J. A., Harper, J. W., Eisenman, R. N., & Clurman, B. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402770101 · Cited by 942 · see citing works
Bouffet, E., Larouche, V., Campbell, B. B., Merico, D., de Borja, R., Aronson, M., Durno, C., Krueger, J., Cabric, V., Ramaswamy, V., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.66.6552 · Cited by 857 · see citing works
Self-citationBender, S., Tang, Y., Lindroth, A. M., Hovestadt, V., Jones, D. T. W., Kool, M., Zapatka, M., Northcott, P. A., Sturm, D., Wang, W., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.10.006 · Cited by 818 · see citing works
Self-citationPhosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7
Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., & Nakayama, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600217 · Cited by 810 · see citing works
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
Chan, K.-M., Fang, D., Gan, H., Hashizume, R., Yu, C., Schroeder, M., Gupta, N., Mueller, S., James, C. D., Jenkins, R., et al. (2013) · Genes & Development · doi:10.1101/gad.217778.113 · Cited by 707 · see citing works
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
Grasso, C. S., Tang, Y., Truffaux, N., Berlow, N. E., Liu, L., Debily, M.-A., Quist, M. J., Davis, L. E., Huang, E. C., Woo, P. J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3855 · Cited by 687 · see citing works
Self-citationCastel, D., Philippe, C., Calmon, R., Dret, L. L., Truffaux, N., Boddaert, N., Pagès, M., Taylor, K. R., Saulnier, P., Lacroix, L., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1478-0 · Cited by 663 · see citing works
Self-citationPaugh, B. S., Qu, C., Jones, C., Liu, Z., Adamowicz‐Brice, M., Zhang, J., Bax, D. A., Coyle, B., Barrow, J., Hargrave, D. R., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.7252 · Cited by 651 · see citing works
Self-citationBuczkowicz, P., Hoeman, C. M., Rakopoulos, P., Pajovic, S., Létourneau, L., Dzamba, M., Morrison, A., Lewis, P. W., Bouffet, É., Bartels, U. K., et al. (2014) · Nature Genetics · doi:10.1038/ng.2936 · Cited by 649 · see citing works
Self-citationEnhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Northcott, P. A., Lee, C., Zichner, T., Stütz, A. M., Erkek, S., Kawauchi, D., Shih, D. J. H., Hovestadt, V., Zapatka, M., Sturm, D., et al. (2014) · Nature · doi:10.1038/nature13379 · Cited by 642 · see citing works
Self-citationPaediatric and adult glioblastoma: multiform (epi)genomic culprits emerge
Sturm, D., Bender, S., Jones, D. T. W., Lichter, P., Grill, J., Becher, O., Hawkins, C., Majewski, J., Jones, C., Costello, J. F., et al. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3655 · Cited by 555 · see citing works
Self-citationRecurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
Taylor, K. R., Mackay, A. G., Truffaux, N., Butterfield, Y. S. N., Morozova, O., Philippe, C., Castel, D., Grasso, C. S., Vinci, M., Carvalho, D. M., et al. (2014) · Nature Genetics · doi:10.1038/ng.2925 · Cited by 522 · see citing works
Self-citationRecurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
Fontebasso, A. M., Papillon-Cavanagh, S., Schwartzentruber, J., Nikbakht, H., Gerges, N., Fiset, P.-O., Bechet, D., Faury, D., De Jay, N., Ramkissoon, L. A., et al. (2014) · Nature Genetics · doi:10.1038/ng.2950 · Cited by 465 · see citing works
Self-citationUse of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation
Funato, K., Major, T., Lewis, P. W., Allis, C. D., & Tabar, V. (2014) · Science · doi:10.1126/science.1253799 · Cited by 390 · see citing works
Shlien, A., Campbell, B. B., de Borja, R., Alexandrov, L. B., Merico, D., Wedge, D. C., Loo, P. V., Tarpey, P. S., Coupland, P. G., Behjati, S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3202 · Cited by 374 · see citing works
Self-citationPediatric high-grade glioma: biologically and clinically in need of new thinking
Jones, C., Karajannis, M. A., Jones, D., Kieran, M. W., Monje, M., Baker, S. J., Becher, O. J., Cho, Y., Gupta, N. M., Hawkins, C. E., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now101 · Cited by 360 · see citing works
Self-citationKorshunov, A., Ryzhova, M. V., Hovestadt, V., Bender, S., Sturm, D., Capper, D., Meyer, J., Schrimpf, D., Kool, M., Northcott, P. A., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1405-4 · Cited by 346 · see citing works
Self-citationTumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities
Davis, R. J., Welcker, M., & Clurman, B. E. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.013 · Cited by 343 · see citing works
The Bloom's Syndrome Gene Product Interacts with Topoisomerase III
Wu, L., Davies, S. L., North, P. S., Goulaouic, H., Riou, J., Turley, H., Gatter, K. C., & Hickson, I. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9636 · Cited by 319 · see citing works
Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
Bjerke, L. M., Mackay, A. G., Nandhabalan, M., Burford, A., Jury, A., Popov, S., Bax, D. A., Carvalho, D. M., Taylor, K. R., Vinci, M., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0426 · Cited by 319 · see citing works
Self-citationPaugh, B. S., Broniscer, A., Qu, C., Miller, C. P., Zhang, J., Tatevossian, R., Olson, J. M., Geyer, J. R., Chi, S. N., da Silva, N. S., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.35.5677 · Cited by 318 · see citing works
Self-citationZarghooni, M., Bartels, U. K., Lee, E., Buczkowicz, P., Morrison, A., Huang, A., Bouffet, É., & Hawkins, C. E. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.5463 · Cited by 313 · see citing works
Self-citationUnique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma
Jones, C., & Baker, S. J. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3811 · Cited by 294 · see citing works
Self-citationFontebasso, A. M., Schwartzentruber, J., Khuong-Quang, D.-A., Liu, X.-Y., Sturm, D., Korshunov, A., Jones, D., Witt, H., Kool, M., Albrecht, S., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1095-8 · Cited by 291 · see citing works
Self-citationSchiffman, J. D., Hodgson, J. G., VandenBerg, S. R., Flaherty, P., Polley, M. C., Yu, M., Fisher, P. G., Rowitch, D. H., Ford, J. M., Berger, M. S., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1851 · Cited by 249 · see citing works
Puget, S., Philippe, C., Bax, D. A., Job, B., Varlet, P., Junier, M., Andreiuolo, F. D. M., Carvalho, D. M., Reis, R., Guerrini‐Rousseau, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030313 · Cited by 243 · see citing works
Self-citationPaediatric and adult malignant glioma: close relatives or distant cousins?
Jones, C., Perryman, L., & Hargrave, D. R. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.87 · Cited by 240 · see citing works
Self-citationNovel Oncogenic <i>PDGFRA</i> Mutations in Pediatric High-Grade Gliomas
Paugh, B. S., Zhu, X., Qu, C., Endersby, R., Diaz, A. K., Zhang, J., Bax, D. A., Carvalho, D., Reis, R. M., Onar-Thomas, A., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1491 · Cited by 235 · see citing works
Self-citationRecurrent MET fusion genes represent a drug target in pediatric glioblastoma
Bender, S., Gröbner, S. N., Pfaff, E., Kool, M., Northcott, P. A., Sturm, D., Worst, B. C., Pfister, S. M., Jones, D. T. W., van Tilburg, C. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4204 · Cited by 233 · see citing works
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Qin, E. Y., Cooper, D. D., Abbott, K. L., Lennon, J., Nagaraja, S., Mackay, A. G., Jones, C., Vogel, H. S., Jackson, P. K., & Monje, M. (2017) · Cell · doi:10.1016/j.cell.2017.07.016 · Cited by 231 · see citing works
Self-citationKorshunov, A., Schrimpf, D., Ryzhova, M. V., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1710-1 · Cited by 227 · see citing works
Hennika, T., Hu, G., Olaciregui, N. G., Barton, K. L., Ehteda, A., Chitranjan, A., Chang, C., Gifford, A. J., Tsoli, M., Ziegler, D. S., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169485 · Cited by 191 · see citing works
Self-citationStructural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors
Richards, M. W., Burgess, S. G., Poon, E., Carstensen, A., Eilers, M., Chesler, L., & Bayliss, R. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610626113 · Cited by 184 · see citing works
A Distinct Spectrum of Copy Number Aberrations in Pediatric High-Grade Gliomas
Bax, D. A., Mackay, A. G., Little, S. E., Carvalho, D. M., Viana‐Pereira, M., Tamber, N., Grigoriadis, A. E., Ashworth, A., Reis, R. M., Ellison, D. W., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0438 · Cited by 155 · see citing works
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Nicolaides, T. P., Li, H., Solomon, D. A., Hariono, S., Hashizume, R., Barkovich, K. J., Baker, S. J., Paugh, B. S., Jones, C., Forshew, T., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1456 · Cited by 152 · see citing works
Self-citationBarrow, J., Adamowicz‐Brice, M., Cartmill, M., et al. (2010) · Neuro-Oncology · doi:10.1093/neuonc/noq158 · Cited by 117 · see citing works
Tiberi, L., Bonnefont, J., van den Ameele, J., Bon, S. D. L., Herpoel, A., Bilheu, A., Baron, B. W., & Vanderhaeghen, P. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.021 · Cited by 101 · see citing works
ACVR1 Mutations in DIPG: Lessons Learned from FOP
Taylor, K. R., Vinci, M., Bullock, A. N., & Jones, C. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1298 · Cited by 89 · see citing works
Self-citationHuman Topoisomerase IIIα Is a Single-stranded DNA Decatenase That Is Stimulated by BLM and RMI1
Yang, J., Bachrati, C. Z., Ou, J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123216 · Cited by 82 · see citing works
Thalamic high-grade gliomas in children: a distinct clinical subset?
Kramm, C. M., Butenhoff, S., Rausche, U., et al. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor045 · Cited by 81 · see citing works
Pediatric gliomas as neurodevelopmental disorders
Baker, S. J., Ellison, D. W., & Gutmann, D. H. (2015) · Glia · doi:10.1002/glia.22945 · Cited by 72 · see citing works
Self-citationTemime‐Smaali, N., Guittat, L., Wenner, T., Bayart, É., Douarre, C., Gómez, D., Giraud-Panis, M.-J. E., Londoño‐Vallejo, A., Gilson, É., Amor-Guéret, M., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.74 · Cited by 71 · see citing works
Temime‐Smaali, N., Guittat, L., Sidibe, A., Shin‐ya, K., Trentesaux, C., & Riou, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006919 · Cited by 70 · see citing works
arrayMap: A Reference Resource for Genomic Copy Number Imbalances in Human Malignancies
Cai, H., Kumar, N., & Baudis, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036944 · Cited by 37 · see citing works
Self-citationProgenetix: 12 years of oncogenomic data curation
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Self-citationCarvalho, D. M., Mackay, A. G., Bjerke, L. M., Grundy, R. G., Lopes, M. C., Reis, R. M., & Jones, C. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-23 · Cited by 23 · see citing works
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- Authors
- Mackay, A., Burford, A., Carvalho, D., Izquierdo, E., Fazal-Salom, J., Taylor, K. R., Bjerke, L., Clarke, M., Vinci, M., Nandhabalan, M., Temelso, S., Popov, S., Molinari, V., Raman, P., Waanders, A. J., Han, H. J., Gupta, S., Marshall, L., Zacharoulis, S., Vaidya, S., Mandeville, H. C., Bridges, L. R., Martin, A. J., Al-Sarraj, S., Chandler, C., Ng, H.-K., Li, X., Mu, K., Trabelsi, S., Brahim, D. H.-B., Kisljakov, A. N., Konovalov, D. M., Moore, A. S., Carcaboso, A. M., Sunol, M., de Torres, C., Cruz, O., Mora, J., Shats, L. I., Stavale, J. N., Bidinotto, L. T., Reis, R. M., Entz-Werle, N., Farrell, M., Cryan, J., Crimmins, D., Caird, J., Pears, J., Monje, M., Debily, M.-A., Castel, D., Grill, J., Hawkins, C., Nikbakht, H., Jabado, N., Baker, S. J., Pfister, S. M., Jones, D. T. W., Fouladi, M., von Bueren, A. O., Baudis, M., Resnick, A., & Jones, C.
- Affiliations
- Institute of Cancer Research (GB)
- Children's Hospital of Philadelphia (US)
- SIB Swiss Institute of Bioinformatics (CH)
- Royal Marsden Hospital (GB)
- St George's Hospital (GB)
- King's College Hospital (GB)
- Chinese University of Hong Kong (HK)
- Shandong University (CN)
- Hôpital Farhat Hached (TN)
- Translational Research Institute (AU)
- Institut de Recerca Sant Joan de Déu (ES)
- Hospital de Câncer de Barretos (BR)
- Beaumont Hospital (IE)
- Temple Street Children's University Hospital (IE)
- Children's Health Ireland at Crumlin (IE)
- Stanford Medicine (US)
- Institut Gustave Roussy (FR)
- Hospital for Sick Children (CA)
- McGill University (CA)
- St. Jude Children's Research Hospital (US)
- German Cancer Research Center (DE)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Jones, Chris
- ORCID
- Mackay, Alan
- Carvalho, Diana
- Izquierdo, Elisa
- Taylor, Kathryn R.
- Clarke, Matthew
- Temelso, Sara
- Popov, Sergey
- Raman, Pichai
- Waanders, Angela J.
- Han, Harry J.
- Gupta, Saumya
- Marshall, Lynley
- Vaidya, Sucheta
- Mandeville, Henry C.
- Martin, Andrew J.
- Ng, Ho-Keung
- Li, Xingang
- Mu, Kun
- Trabelsi, Saoussen
- Moore, Andrew S.
- Carcaboso, Angel Montero
- Cruz, Ofelia
- Mora, Jaume
- Bidinotto, Lucas T.
- Reis, Rui M.
- Pears, Jane
- Monje, Michelle
- Debily, Marie-Anne
- Castel, David
- Grill, Jacques
- Hawkins, Cynthia
- Nikbakht, Hamid
- Jabado, Nada
- Baker, Suzanne J.
- Pfister, Stefan M.
- Jones, David T.W.
- Fouladi, Maryam
- Baudis, Michael
- Resnick, Adam
- Jones, Chris
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 32
- Issue
- 4
- Pages
- 520-537.e5
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC5637314
- OpenAlex
- W2751187578
- Cited by
- 1,212
- References
- 56
- Citations by year
- 2026: 127 · 2025: 136 · 2024: 189 · 2023: 156 · 2022: 145 · 2021: 162 · 2020: 150 · 2019: 94 · 2018: 46 · 2017: 5 · 2014: 1
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cancer Cell (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RepositóriUM (Universidade do Minho) (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
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- HAL (submittedVersion, cc-by)
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- Zurich Open Repository and Archive (University of Zurich)
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- Funders
- Cancer Research UK (C13468/A13982, C13468/A23536)
- CRIS Cancer Foundation
- Abbie's Army and the DIPG Collaborative
- Cure Starts Now Foundation
- Christopher's Smile
- McKenna Claire Foundation
- Lyla Nsouli Foundation
- National Institutes of Health (R01NS085336, R01NS091620)
- The Dragon Master Foundation
- The Kortney Rose Foundation
- The Musella Foundation For Brain Tumor Research & Information
- Gray Matters Foundation
- Pediatric Brain Tumor Foundation
- Brain Tumour Charity
- Great Ormond Street Children's Charity
- Children with Cancer UK
- NHS
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- pediatric high-grade glioma, diffuse intrinsic pontine glioma, H3.3K27M, BCOR mutation, genetic abnormalities, tumor age, molecular subtypes, dysregulated pathways, treatment stratification
- MeSH terms
- F-Box-WD Repeat-Containing Protein 7, Adolescent, Child, Child, Preschool, DNA Topoisomerases, Type I, Female, Glioma, Histones, Humans, Infant, Infant, Newborn, Male, Mutation, Proto-Oncogene Proteins, Repressor Proteins, Gene Dosage, Cell Cycle Proteins, Brain Stem Neoplasms, Ubiquitin-Protein Ligases, F-Box Proteins, Young Adult, Exome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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