Cited by 272Cancer, Stress, Anesthesia, and Immune ResponseVagus Nerve Stimulation ResearchNerve injury and regeneration

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Nerve–Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression

Jobling, Phillip, Pundavela, Jay, Oliveira, Sonia M.R., Roselli, Séverine, Walker, Marjorie M., Hondermarck, Hubert·2015·Cancer Research

DOI 10.1158/0008-5472.can-14-3180

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Abstract

Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate cancer cell growth and dissemination. This mechanism involves the release of neurotransmitters, such as catecholamines and acetylcholine, directly into the vicinity of cancer and stromal cells to activate corresponding membrane receptors. Conversely, the secretion of neurotrophic growth factors by cancer cells drives the outgrowth of nerves in solid tumors. This reciprocal interaction between nerves and cancer cells provides new insights into the cellular and molecular bases of tumorigenesis and points to the potential utility of antineurogenic therapies. This review will discuss our evolving understanding of the cross-talk between nerves and cancer cells. Cancer Res; 75(9); 1777–81. ©2015 AACR.

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Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
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Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature · doi:10.1038/nature11547 · Cited by 2,058
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
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Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S. (2013) · Science · doi:10.1126/science.1236361 · Cited by 1,287
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Denervation suppresses gastric tumorigenesis
Zhao, C., Hayakawa, Y., Kodama, Y., Muthupalani, S., Westphalen, C. B., Andersen, G. T., Flatberg, A., Johannessen, H., Friedman, R. A., Renz, B. W., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009569 · Cited by 687
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Barron, T. I., Connolly, R. M., Sharp, L., Bennett, K., & Visvanathan, K. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.5422 · Cited by 532
Perineural invasion and associated pain in pancreatic cancer
Bapat, A., Hostetter, G. H., Hoff, D. D. V., & Han, H. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3131 · Cited by 502
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Authors: Jobling, P., Pundavela, J., Oliveira, S. M. R., Roselli, S., Walker, M. M., & Hondermarck, H.
Affiliations: Hunter Medical Research Institute (AU)
ORCID: Jobling, Phillip
Pundavela, Jay
Oliveira, Sonia M.R.
Roselli, Séverine
Walker, Marjorie M.
Hondermarck, Hubert
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2015-04-30
Volume: 75
Issue: 9
Pages: 1777-1781
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-14-3180
OpenAlex: W2128366974
Cited by: 272
References: 34
Citations by year: 2026: 14 · 2025: 22 · 2024: 27 · 2023: 26 · 2022: 28 · 2021: 30 · 2020: 50 · 2019: 30 · 2018: 14 · 2017: 16 · 2016: 10 · 2015: 5
FWCI: 2.07
Type: journal article
Language: en
Open access: closed
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
NOVA (University of Newcastle Australia) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: tumor microenvironment, tumor progression, neurotrophins, neurotransmitters, catecholamines, acetylcholine, catecholamine receptors, acetylcholine receptor, cancer cell dissemination, tumor stromal cells
MeSH terms: Animals, Humans, Neoplasms, Nerve Growth Factors, Neurons, Disease Progression, Tumor Microenvironment, Carcinogenesis

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Nerve–Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression

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