Autonomic nerve development contributes to prostate cancer progression
Abstract
Cancer Hits a Nerve: Solid tumors sculpt their microenvironment to maximize their growth and metastatic potential. This concept is illustrated most famously by tumor angiogenesis, a process whereby tumors induce the growth of new blood vessels to boost their supply of oxygen and blood-borne nutrients. Magnon et al. (p. 10.1126/science.1236361 ; see the Perspective by Isaacs ) now highlight the important contribution made by another microenvironmental component—developing autonomic nerve fibers—to tumor growth and metastasis. In mouse models of prostate cancer, surgical or chemical destruction of sympathetic nerves prevented early-stage growth of tumors, whereas pharmacological inhibition of parasympathetic nerves inhibited tumor dissemination. In a small study of human prostate cancer specimens, the presence of a high density of nerve fibers in and around the tumor tissue was found to correlate with poor clinical outcome. These results raise the possibility that drugs targeting the autonomic nervous system may have therapeutic potential for prostate cancer.
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SNS dysfunction is closely associated with metabolic syndrome, oncogenic activation, neoplastic growth and tumor initiation.
“SNS dysfunction is closely associated with metabolic syndrome, oncogenic activation, neoplastic growth and tumor initiation (Lee et al., 2010; Magnon et al., 2013; Tentolouris et al., 2006).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Magnon et al., 2013
Sympathetic dysfunction and peripheral clock disruption have been linked to oncogenic activation and increased risk of cancer.
“both of which have been linked to oncogenic activation and increased risk of cancer (Kettner NM, 2016; Lee et al., 2010; Magnon et al., 2013).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Magnon et al., 2013
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- Authors
- Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S.
- Affiliations
- Albert Einstein College of Medicine (US)
- Icahn School of Medicine at Mount Sinai (US)
- Duke University (US)
- Corresponding author
- Magnon, Claire
- Frenette, Paul S.
- Venue
- Science
- Published
- 2013-07-12
- Volume
- 341
- Issue
- 6142
- Pages
- 1236361-1236361
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049959255
- Cited by
- 1,287
- References
- 36
- Citations by year
- 2026: 136 · 2025: 128 · 2024: 127 · 2023: 119 · 2022: 116 · 2021: 120 · 2020: 120 · 2019: 85 · 2018: 78 · 2017: 66 · 2016: 66 · 2015: 56 · 2014: 46 · 2013: 23
- FWCI
- 45.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL069438, HL097819, R01HL069438, R01HL097819)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638, DK056638)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- prostate cancer, autonomic nerves, tumor microenvironment, sympathetic nerves, parasympathetic nerves, cholinergic fibers, adrenergic receptors, muscarinic receptors, metastasis, tumor invasion
- MeSH terms
- Adenocarcinoma, Adrenergic Fibers, Animals, Autonomic Nervous System, Cell Transformation, Neoplastic, Cholinergic Fibers, Humans, Male, Mice, Transgenic, Neoplasm Invasiveness, Neoplasm Transplantation, Nerve Net, Parasympathetic Nervous System, Promoter Regions, Genetic, Prostate, Prostatic Neoplasms, Genes, myc, Disease Progression, Cell Line, Tumor, Mice, Neurogenesis
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