Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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QIIME allows analysis of high-throughput community sequencing data

Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887

Metagenomic biomarker discovery and explanation

Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760

UniFrac: a New Phylogenetic Method for Comparing Microbial Communities

Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Routy, B., Le Chatelier, E., Derosa, L., Duong, C. P. M., Alou, M. T., Daillère, R., Fluckiger, A., Messaoudene, M., Rauber, C., Roberti, M. P., et al. (2018) · Science · doi:10.1126/science.aan3706 · Cited by 5,671

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Charoentong, P., Finotello, F., Angelova, M., Mayer, C., Efremova, M., Rieder, D., Hackl, H., & Trajanoski, Z. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.019 · Cited by 5,041

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., et al. (2018) · Science · doi:10.1126/science.aan4236 · Cited by 4,812 · cited 2×

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251

Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy

Kang, X., Lau, H. C.-H., & Yu, J. Q. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101478 · Cited by 172

Efficacy of fecal microbiota transplantation in patients with Parkinson’s disease: clinical trial results from a randomized, placebo-controlled design

Cheng, Y., Tan, G., Zhu, Q., Wang, C., Ruan, G., Ying, S., Qie, J., Hu, X., Xiao, Z., Xu, F., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2284247 · Cited by 147

Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Wu, H., Leng, X., Liu, Q., Mao, T., Jiang, T., Liu, Y., Li, F., Cao, C., Fan, J., Chen, L., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2593 · Cited by 154

Chemical Compounds of Berry-Derived Polyphenols and Their Effects on Gut Microbiota, Inflammation, and Cancer

Bouyahya, A., Omari, N. E., Hachlafi, N. E., Jemli, M. E., Hakkour, M., Balahbib, A., Menyiy, N. E., Bakrim, S., Mrabti, H. N., Khouchlaa, A., et al. (2022) · Molecules · doi:10.3390/molecules27103286 · Cited by 123

The gut microbiome and cancer: from tumorigenesis to therapy

Nobels, A., van Marcke, C., Jordan, B. F., Hul, M. V., & Cani, P. D. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01287-w · Cited by 126

The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful!

Nandi, D., Parida, S., & Sharma, D. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221452 · Cited by 103

Role of the tumor microenvironment in cancer hallmarks and targeted therapy (Review)

Naser, R., Fakhoury, I., El‑Fouani, A., Abi‑Habib, R., & El‑Sibai, M. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5471 · Cited by 61

Prevotella copri exhausts intrinsic indole-3-pyruvic acid in the host to promote breast cancer progression: inactivation of AMPK via UHRF1-mediated negative regulation

Su, J., Lin, X., Li, D., Yang, C.-M., Lv, S., Chen, X., Yang, X., Pan, B., Xu, R. P., Ren, L., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2347757 · Cited by 59

Role of Gut Microbiota in Breast Cancer and Drug Resistance

Sathiyapriya, V., Parida, S., Lingipilli, B. T., Ramalingam, K., Podipireddy, D. R., & Muniraj, N. (2023) · Pathogens · doi:10.3390/pathogens12030468 · Cited by 57

Analysis of Gut Microbiota in Patients with Breast Cancer and Benign Breast Lesions

Ma, Z., Qu, M., & Wang, X. (2022) · Polish Journal of Microbiology · doi:10.33073/pjm-2022-019 · Cited by 54

Modulating Microbiota as a New Strategy for Breast Cancer Prevention and Treatment

Wu, H., Ganguly, S., & Tollefsbol, T. O. (2022) · Microorganisms · doi:10.3390/microorganisms10091727 · Cited by 53

Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis

Thu, M. S., Chotirosniramit, K., Nopsopon, T., Hirankarn, N., & Pongpirul, K. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1144021 · Cited by 54

Microbial Therapy and Breast Cancer Management: Exploring Mechanisms, Clinical Efficacy, and Integration within the One Health Approach

Filippou, C., Themistocleous, S., Marangos, G., Panayiotou, Y., Fyrilla, M., Kousparou, C. A., Pana, Z. D., Tsioutis, C., Johnson, E. O., & Yiallouris, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021110 · Cited by 49

Potential role of gut microbiota in prostate cancer: immunity, metabolites, pathways of action?

Zha, C., Peng, Z., Huang, K., Tang, K., Wang, Q., Zhu, L. J., Che, B., Li, W., Xu, S., Huang, T., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1196217 · Cited by 49

The role of the gut microbiota in chemotherapy response, efficacy and toxicity: a systematic review

Böhm, D. T. M. M., Russ, E., Guchelaar, H., Ziemons, J., Penders, J., Smidt, M. L., van Best, N., & Deenen, M. J. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01034-0 · Cited by 53

Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study

Yang, P., Wang, Z., Peng, Q., Lian, W., & Chen, D. (2021) · Evolutionary Bioinformatics · doi:10.1177/11769343211057573 · Cited by 47

The conundrum of breast cancer and microbiome - A comprehensive review of the current evidence

Papakonstantinou, A., Nuciforo, P. G., Borrell, M., Zamora, E., Pimentel, I., Saura, C., & Oliveira, M. (2022) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2022.102470 · Cited by 45

Novel Therapies and Strategies to Overcome Resistance to Anti-HER2-Targeted Drugs

Gámez-Chiachio, M., Sarrió, D., & Moreno‐Bueno, G. (2022) · Cancers · doi:10.3390/cancers14184543 · Cited by 49

Gut Microbiota and Tumor Immune Escape: A New Perspective for Improving Tumor Immunotherapy

He, Y., Huang, J., Li, Q., Xia, W., Zhang, C., Liu, Z., Xiao, J., Yi, Z., Deng, H., Xiao, Z., et al. (2022) · Cancers · doi:10.3390/cancers14215317 · Cited by 47

Microbiome Assisted Tumor Microenvironment: Emerging Target of Breast Cancer

Malla, R. R., Marni, R., Kumari, S., Chakraborty, A., & Pappu, L. (2021) · Clinical Breast Cancer · doi:10.1016/j.clbc.2021.09.002 · Cited by 44

Gut microbiome model predicts response to neoadjuvant immunotherapy plus chemoradiotherapy in rectal cancer

Yang, Z., Ma, J., Han, J., Li, A., Liu, G., Sun, Y., Zheng, J., Zhang, J., Chen, G., Xu, R., et al. (2024) · Med · doi:10.1016/j.medj.2024.07.002 · Cited by 45

Gut microbiome causal impacts on the prognosis of breast cancer: a Mendelian randomization study

Hong, W., Huang, G., Wang, D., Xu, Y., Qiu, J., Pei, B., Qian, D., & Meng, X. (2023) · BMC Genomics · doi:10.1186/s12864-023-09608-7 · Cited by 42

The role of gut microbiota in tumorigenesis and treatment

Xu, J., Liu, M.-T., Tao, T., Zhu, X. M., & Fei, F. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111444 · Cited by 41

The crosstalk between the gut microbiota and tumor immunity: Implications for cancer progression and treatment outcomes

Wang, M., Zhang, L., Chang, W., & Zhang, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1096551 · Cited by 44

Fecal microbiota transplantation to enhance cancer treatment outcomes across different cancer types: A systematic literature review

Wekking, D., van den Ende, T., Bijlsma, M. F., Vidal-Itriago, A., Nieuwdorp, M., & van Laarhoven, H. W. M. (2025) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2025.103025 · Cited by 43

Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer

Boutriq, S., González-González, A., Plaza-Andrades, I. J., Laborda-Illanes, A., Sánchez‐Alcoholado, L., Peralta-Linero, J., Domínguez-Recio, M. E., Bermejo-Pérez, M. J., Lavado-Valenzuela, R., Alba, E., et al. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11070659 · Cited by 39

Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality

Guillot, N., Roméo, B., Manesh, S. S., Milano, G., Brest, P., Zitvogel, L., Hofman, P., & Mograbi, B. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.08.004 · Cited by 36

Optimizing Cancer Treatment Through Gut Microbiome Modulation

Kim, K., Lee, M., Shin, Y., Lee, Y., & Kim, T. J. (2025) · Cancers · doi:10.3390/cancers17071252 · Cited by 37

Cancer's second genome: Microbial cancer diagnostics and redefining clonal evolution as a multispecies process: Humans and their tumors are not aseptic, and the multispecies nature of cancer modulates clinical care and clonal evolution

Sepich‐Poore, G. D., Guccione, C., Laplane, L., Pradeu, T., Curtius, K., & Knight, R. (2022) · BioEssays · doi:10.1002/bies.202100252 · Cited by 33

Antibiotics modulate neoadjuvant therapy efficiency in patients with breast cancer: a pilot analysis

Zhang, X., Yu, L., Shi, J., Li, S., Yang, S., Gao, W., Yang, S., Cheng, M., Wang, H., Guo, Z., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93428-w · Cited by 32

Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors

Li, Y., Jiang, H., Wang, X., Liu, X., Huang, Y., Wang, Z., Ma, Q., Dong, L., Qi, Y., Zhang, H., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.881071 · Cited by 33

Gut microbiota interact with breast cancer therapeutics to modulate efficacy

Arnone, A. A., Ansley, K. C., Heeke, A. L., Howard-McNatt, M. M., & Cook, K. L. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00185-0 · Cited by 37

The Link Between the Microbiota and HER2+ Breast Cancer: The New Challenge of Precision Medicine

Modica, M. D., Arlotta, V., Sfondrini, L., Tagliabue, E., & Triulzi, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.947188 · Cited by 31

Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice

Huang, R., Shen, Z.-Y., Huang, D., Zhao, S.-H., Dan, L.-X., Wu, P., Tang, Q., & Ma, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-58107-8 · Cited by 34

Exercise and Prebiotic Fiber Provide Gut Microbiota-Driven Benefit in a Survivor to Germ-Free Mouse Translational Model of Breast Cancer

Sampsell, K., Wang, W., Ohland, C., Mager, L. F., Pett, N., Lowry, D. E., Sales, K. M., McNeely, M. L., McCoy, K. D., Culos-Reed, S. N., et al. (2022) · Cancers · doi:10.3390/cancers14112722 · Cited by 29

Gut–lung axis: role of the gut microbiota in non-small cell lung cancer immunotherapy

Zhang, H., & Xu, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1257515 · Cited by 31

Microbiome in Cancer Development and Treatment

Čierniková, S., Ševčíková, A., Mladosievičová, B., & Mego, M. (2023) · Microorganisms · doi:10.3390/microorganisms12010024 · Cited by 29

Gut Lactobacillus contribute to the progression of breast cancer by affecting the anti-tumor activities of immune cells in the TME of tumor-bearing mice

Shi, Q. W., Wang, J., Zhou, M., Zheng, R., Zhang, X., & Liu, B. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111039 · Cited by 27

Immunotherapies against HER2-Positive Breast Cancer

Duro‐Sánchez, S., Alonso, M. R., & Arribas, J. (2023) · Cancers · doi:10.3390/cancers15041069 · Cited by 29

Gut microbiome influences incidence and outcomes of breast cancer by regulating levels and activity of steroid hormones in women

Chapadgaonkar, S. S., Bajpai, S., & Godbole, M. S. (2023) · Cancer Reports · doi:10.1002/cnr2.1847 · Cited by 28

Gut microbiota diversity is prognostic and associated with benefit from chemo-immunotherapy in metastatic triple-negative breast cancer

Ullern, A., Holm, K., Røssevold, A. H., Andresen, N. K., Bang, C., Lingjærde, O. C., Naume, B., Hov, J. R., & Kyte, J. A. (2025) · Molecular Oncology · doi:10.1002/1878-0261.13760 · Cited by 25

Effect of Chemotherapy on the Gut Microbiome of Breast Cancer Patients During the First Year of Treatment

Wu, A. H., Vigen, C. L. P., Tseng, C.-C., García, A. A., & SPICER, D. V. (2022) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s305486 · Cited by 30

Chemotherapy-associated oral microbiome changes in breast cancer patients

Klymiuk, I., Bilgilier, C., Mahnert, A., Prokesch, A., Heininger, C., Brandl, I., Sahbegovic, H., Singer, C. F., Fuereder, T., & Steininger, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.949071 · Cited by 24

Specific microbiome patterns and their association with breast cancer: the intestinal microbiota as a potential biomarker and therapeutic strategy

Amaro-da-Cruz, A., Rubio‐Tomás, T., & Álvarez‐Mercado, A. I. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03554-w · Cited by 22

Remodeling the tumor dormancy ecosystem to prevent recurrence and metastasis

Liang, Y., Chen, W., Zhang, Y., & Li, L. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02328-2 · Cited by 29

Navigating the complex relationship between human gut microbiota and breast cancer: Physiopathological, prognostic and therapeutic implications

Schettini, F., Gattazzo, F., Nucera, S., Rubio-García, E., López-Aladid, R., Morelli, L., Fontana, A., Vigneri, P. G., Casals‐Pascual, C., Iebba, V., et al. (2024) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2024.102816 · Cited by 22

Interactions between the tumor microbiota and breast cancer

Guo, H. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1499203 · Cited by 22

Emerging insights into mechanisms of trastuzumab resistance in HER2-positive cancers

Wu, X., Huang, S., He, W., & Song, M. L. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110602 · Cited by 23

L-norvaline affects the proliferation of breast cancer cells based on the microbiome and metabolome analysis

Zhu, Q., Zai, H., Zhang, K., Zhang, X., Luo, N., Li, X., Hu, Y., & Wu, Y. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15620 · Cited by 20

Tumor immune microenvironment and systemic response in breast cancer

Kawaguchi, K., Maeshima, Y., & Toi, M. (2022) · Medical Oncology · doi:10.1007/s12032-022-01782-0 · Cited by 21

Microbiota-centered interventions to boost immune checkpoint blockade therapies

Almonte, A. A., Thomas, S., & Zitvogel, L. (2025) · Journal of Experimental Medicine · doi:10.1084/jem.20250378 · Cited by 19

Exploring the human microbiome – A step forward for precision medicine in breast cancer

Jotshi, A., Sukla, K. K., Haque, M. M., Bose, C., Varma, B., Koppiker, C. B., Joshi, S., & Mishra, R. (2023) · Cancer Reports · doi:10.1002/cnr2.1877 · Cited by 20

Akkermansia muciniphila ameliorates doxorubicin-induced cardiotoxicity by regulating PPARα-dependent mitochondrial biogenesis

Lin, H., Shao, X., Gu, H., Yu, X., He, L., Zhou, J., Zhong, Z., Guo, S., Li, D., Chen, F., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00712-y · Cited by 18

Changes in the fecal microbiota of breast cancer patients based on 16S rRNA gene sequencing: a systematic review and meta-analysis

Luan, B., Ge, F., Lu, X., Li, Z., Zhang, H., Wu, J., Yang, Q., Chen, L., Zhang, W., & Chen, W. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03373-5 · Cited by 18

Obesity, dysbiosis and inflammation: interactions that modulate the efficacy of immunotherapy

Yende, A. S., & Sharma, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1444589 · Cited by 19

Bruceae Fructus Oil Inhibits Triple-Negative Breast Cancer by Restraining Autophagy: Dependence on the Gut Microbiota-Mediated Amino Acid Regulation

Su, J., Chen, X., Xiao, Y., Li, D., Li, M., Li, H., Huang, J., Lai, Z., Su, Z., Xie, Y., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.727082 · Cited by 17

A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells

Qin, G., Shao, X., Liu, X., Xu, J., Wang, X., Wang, W., Gao, L., Liang, Y., Xie, L., Su, D., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2421710122 · Cited by 17

Potential risk of tamoxifen: gut microbiota and inflammation in mice with breast cancer

Li, H., Gao, X., Chen, Y., Wang, M., Xu, C., Yu, Q., Jin, Y., Song, J., & Zhu, Q. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1121471 · Cited by 16

Social Isolation and Breast Cancer

Hilakivi-Clarke, L. A., & Andrade, F. D. O. (2023) · Endocrinology · doi:10.1210/endocr/bqad126 · Cited by 22

Intratumoral Stenotrophomonas Maltophilia in Breast Cancer: Unraveling the Interplay with Hormone Receptors and Impact on Tumor Immunity

Zhang, Q., Wang, D., Zhuo, G., Wang, S., Yuan, Y., Wang, L., Ji, L., Wan, Y., Liu, G., & Pan, Y. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.98260 · Cited by 16

Targeting microbiota-host interactions with resveratrol on cancer: Effects and potential mechanisms of action

Wang, P., Shang, R., Ma, Y., Wang, D., Zhao, W., Chen, F., Hu, X., & Zhao, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2106180 · Cited by 15

Friend and foe: the regulation network of ascites components in ovarian cancer progression

Geng, Z., Pan, X., Xu, J., & Jia, X. (2022) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-022-00698-8 · Cited by 15

A Microphysiological System with an Anaerobic Air‐Liquid Interface and Functional Mucus Layer for Coculture of Intestinal Bacteria and Primary Human Colonic Epithelium

Kim, R., & Allbritton, N. L. (2024) · Advanced Materials Interfaces · doi:10.1002/admi.202400093 · Cited by 15

Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products

Li, D., Lan, X., Xu, L., Zhou, S., Luo, H., Zhang, X., Yu, W., Yang, Y., & Fang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1552010 · Cited by 17

Gastrointestinal Microbiota and Breast Cancer Chemotherapy Interactions: A Systematic Review

Csendes, D., Gutlapalli, S. D., Prakash, K., Swarnakari, K. M., Bai, M., Manoharan, M. P., Raja, R., Jamil, A., Desai, A., Desai, D. M., et al. (2022) · Cureus · doi:10.7759/cureus.31648 · Cited by 16

Microbiome-targeted nanoplatforms and engineering approaches in breast cancer therapy

Sabeel, Z., & Zhao, Y. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02456-x · Cited by 17

Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state

Bersier, L., Lorenzo‐Martín, L. F., Chiang, Y.-H., Durot, S., Czauderna, A., Yarahmadov, T., Wyss, T., Roçi, I., Kim, J., Zamboni, N., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67169-7 · Cited by 15

Microbial metabolites in tumor epigenetic regulation

Zhang, W., Zhang, H., Liao, Y., Jiang, S., Zhang, H., Huang, C., Song, Z., Zhao, R., Lü, P., Kang, X., et al. (2026) · iMeta · doi:10.1002/imt2.70115 · Cited by 17

Unraveling the connections between gut microbiota, stress, and quality of life for holistic care in newly diagnosed breast cancer patients

Lee, C., Yang, H., Liu, C.-J., Lee, F., Ko, W.-C., Chang, Y., & Yang, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-45123-1 · Cited by 16

The immunoregulatory role of gut microbiota in the incidence, progression, and therapy of breast cancer

Xue, K., Li, J., & Huang, R. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1411249 · Cited by 14

The gut microbiome and the brain

Rykalo, N. A., Riehl, L., & Kress, M. (2024) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000717 · Cited by 16

Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review)

Xinyuan, T., Yu, L., Jianping, S., Rongwei, Z., Ruiwen, S., Ye, Z., Zhao, J., Chun-fang, T., Hongwei, C., & Haibin, G. (2023) · Oncology Reports · doi:10.3892/or.2023.8618 · Cited by 14

Current and future research on the association between gut microbiota and breast cancer

Liu, K., Jia, N., Shi, H., & Ran, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1272275 · Cited by 13

Guideline for designing microbiome studies in neoplastic diseases

Mikó, E., Sipos, A., Tóth, E., Lehoczki, A., Fekete, M., Sebő, É., Kardos, G., & Bai, P. (2024) · GeroScience · doi:10.1007/s11357-024-01255-4 · Cited by 13

A High Immune-Related Index with the Suppression of cGAS-STING Pathway is a Key Determinant to Herceptin Resistance in HER2+ Breast Cancer

Cai, R., Chen, Q., Zhao, D., Wang, Y., Zhou, L., Zhang, K., Shan, J., Li, Z., Chen, Y., Zhang, H., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.94868 · Cited by 13

Precision preclinical modeling to advance cancer treatment

Gutmann, D. H., Boehm, J. S., Karlsson, E. K., Padron, E., Seshadri, M., WALLIS, D. E., & Snyder, J. C. (2024) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djae249 · Cited by 14

Curcumin-Modified Selenium Nanoparticles Improve S180 Tumour Therapy in Mice by Regulating the Gut Microbiota and Chemotherapy

Zhang, R., Zhang, W., Zhang, Q., Wang, L., Yang, F., Sun, W., Xu, Z., Wang, C., Song, X., & Wang, M. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s476686 · Cited by 15

Prognostic value of tumor-infiltrating lymphocyte subtypes and microorganisms in triple-negative breast cancer

Shi, Y., Guo, Z., Wang, Q., & Deng, H. (2024) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_41_24 · Cited by 13

Unraveling the links between estrogen and gut microbiota in sex-hormone driven cancers

Tahri, A., & Amedei, A. (2025) · World Journal of Clinical Oncology · doi:10.5306/wjco.v16.i9.108819 · Cited by 17

Crohn’s disease and breast cancer: a literature review of the mechanisms and treatment

Zhou, S., & Yu, J. (2023) · Internal and Emergency Medicine · doi:10.1007/s11739-023-03281-0 · Cited by 12

The gut microbiota in patients with polycythemia vera is distinct from that of healthy controls and varies by treatment

Eickhardt‐Dalbøge, C. S., Ingham, A. C., Andersen, L. O., Nielsen, H. V., Fuursted, K., Stensvold, C. R., Larsen, M. K., Kjær, L., Christensen, S. F., Knudsen, T. A., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022008555 · Cited by 14

Integrating immunotherapy with conventional treatment regime for breast cancer patients- an amalgamation of armamentarium

Nandi, D., & Sharma, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1477980 · Cited by 11

Microbiome—Stealth Regulator of Breast Homeostasis and Cancer Metastasis

Furuta, S. (2024) · Cancers · doi:10.3390/cancers16173040 · Cited by 10

Understanding the relationship between breast cancer, immune checkpoint inhibitors, and gut microbiota: a narrative review

Hrubesz, G., Leigh, J., & Ng, T. L. (2024) · Translational Breast Cancer Research · doi:10.21037/tbcr-24-14 · Cited by 10

Optimizing breast cancer chemotherapy by harnessing gut microbiota with insights from artificial intelligence

Zhou, Y., Jiang, M., Shen, K., He, T., Zhou, S., Shao, A., Li, X., Wang, J., Wu, R., Singla, R. K., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00825-4 · Cited by 9

Association of antibiotic exposure with residual cancer burden in HER2-negative early stage breast cancer

Kulkarni, A. A., Jain, A., Jewett, P. I., Desai, N., Veer, L. V. ‘., Hirst, G. L., Yee, D., & Blaes, A. H. (2024) · npj Breast Cancer · doi:10.1038/s41523-024-00630-w · Cited by 9

Microbial Signatures in Breast Cancer: Exploring New Potentials Across Body Niches

Wong, A. Y. W., Bicchieraro, G., Palumbo, I., Ciabattoni, A., Aristei, C., & Spaccapelo, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178654 · Cited by 8

Microbiota in drug resistance

Jia, R. F., Xiao, C., Zhang, Y., Hu, L.-Y., Jun-jun, Y., Zuo, R., Hu, Y., Xie, Y.-H., Ma, X., Li, Q., et al. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101311 · Cited by 8

Baseline gut microbiota as a predictive marker for the efficacy of neoadjuvant chemotherapy in patients with early breast cancer: a multicenter prospective cohort study in the Setouchi Breast Project-14

Nakamoto, S., Kajiwara, Y., Taniguchi, K., Hida, A. I., Miyoshi, Y., Kin, T., Yamamoto, M., Takabatake, D., Kubo, S., Hikino, H., et al. (2024) · Breast Cancer Research and Treatment · doi:10.1007/s10549-024-07395-7 · Cited by 12

Unveiling the microbial influence: bacteria’s dual role in tumor metastasis

Lin, L.-Y., & Zhang, D. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1524887 · Cited by 7

Effect of partially hydrolyzed guar gum on the composition and metabolic function of the intestinal flora of healthy mice

Liu, T., Hu, X., Chen, P., Zhang, R., Zhang, S., Chang, W., Wang, J., & Wang, S. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14508 · Cited by 8

Intestinal Lachnospiraceae bacterium-derived propionate inhibits the progression of clear cell renal cell carcinoma

Xu, J., Chen, H., Yu, Y.-Y., Chen, T., Wang, Y., Xue, W., Zheng, J., Liu, J., & Zhai, W. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102410 · Cited by 8

Anthracyclines and trastuzumab associated cardiotoxicity: is the gut microbiota a friend or foe? – a mini-review

Nobre, J. G., Gaspar, I., & Costa, D. A. (2023) · Frontiers in Microbiomes · doi:10.3389/frmbi.2023.1217820 · Cited by 8

Targeting gut and intratumoral microbiota: a novel strategy to improve therapy resistance in cancer with a focus on urologic tumors

Wu, B., Quan, C., He, Y., Matsika, J., Huang, J., Liu, B., & Chen, J. (2024) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2024.2371543 · Cited by 6

Role of a Whole Plant Foods Diet in Breast Cancer Prevention and Survival

Jiménez, M. D. C. F.-F. (2025) · Journal of the American Nutrition Association · doi:10.1080/27697061.2024.2442631 · Cited by 7

Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

Andrade, F. D. O., Verma, V., & Hilakivi-Clarke, L. A. (2022) · Cancer Reports · doi:10.1002/cnr2.1752 · Cited by 5

Elucidating the Intricate Roles of Gut and Breast Microbiomes in Breast Cancer Metastasis to the Bone

Naik, A., & Godbole, M. S. (2024) · Cancer Reports · doi:10.1002/cnr2.70005 · Cited by 6

Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases

Kapoor, S., Gupta, M., Sapra, L., Kaur, T., & Srivastava, R. K. (2024) · Bone Reports · doi:10.1016/j.bonr.2024.101809 · Cited by 5

Xenobiotics mediated modulation of gut microbiota and its role in lifestyle diseases: a critical appraisal on exposomics

Behl, A., & Sharma, K. K. (2025) · Letters in Applied Microbiology · doi:10.1093/lambio/ovaf067 · Cited by 6

The Impact of Microbiome on Breast Cancer and Regulatory Strategies

Wang, J., Xu, D., Hu, S., Zheng, B., Chen, Y., & Pan, T. (2025) · Microorganisms · doi:10.3390/microorganisms14010075 · Cited by 5

Abstract 4959: The gut microbiota contributes to the effectiveness of HER2-targeted therapy

Modica, M. D., Regondi, V., Gargari, G., Bonizzi, A., Arioli, S., Belmonte, B., Tripodo, C., Guglielmetti, S., Corsi, F., Triulzi, T., et al. (2019) · Immunology · doi:10.1158/1538-7445.sabcs18-4959

Gut microbiota and trastuzumab response in HER2-positive breast cancer

Modica, M. D. (2020) · Open Research Online (The Open University) · doi:10.21954/ou.ro.00010e85 · Cited by 3

Abstract P4-10-32: Commensal gut microbiota influences efficacy of trastuzumab in patients with HER2-positive breast carcinoma

Tagliabue, E., Modica, M. D., Gargari, G., Regondi, V., Bonizzi, A., Arioli, S., Corsi, F., Guglielmetti, S., & Triulzi, T. (2020) · Cancer Research · doi:10.1158/1538-7445.sabcs19-p4-10-32 · Cited by 1

Towards Taming the Bugs to Improve the Drugs for Breast Cancer

Sharma, D. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0300 · Cited by 4

Abstract PS3-12-02: Microbiota disruption with oral antibiotics has a detrimental effect on HER2+ breast cancer therapy efficacy

Araya, R. E., Parker, L. J., Mitra, P., Erlichman, N., Chalasani, P., & Li, R. (2026) · Clinical Cancer Research · doi:10.1158/1557-3265.sabcs25-ps3-12-02