Junctional Adhesion Molecules in Cancer: A Paradigm for the Diverse Functions of Cell–Cell Interactions in Tumor Progression
Open accessAbstract
Tight junction (TJ) proteins are essential for mediating interactions between adjacent cells and coordinating cellular and organ responses. Initial investigations into TJ proteins and junctional adhesion molecules (JAM) in cancer suggested a tumor-suppressive role where decreased expression led to increased metastasis. However, recent studies of the JAM family members JAM-A and JAM-C have expanded the roles of these proteins to include protumorigenic functions, including inhibition of apoptosis and promotion of proliferation, cancer stem cell biology, and epithelial-to-mesenchymal transition. JAM function by interacting with other proteins through three distinct molecular mechanisms: direct cell–cell interaction on adjacent cells, stabilization of adjacent cell surface receptors on the same cell, and interactions between JAM and cell surface receptors expressed on adjacent cells. Collectively, these diverse interactions contribute to both the pro- and antitumorigenic functions of JAM. In this review, we discuss these context-dependent functions of JAM in a variety of cancers and highlight key areas that remain poorly understood, including their potentially diverse intracellular signaling networks, their roles in the tumor microenvironment, and the consequences of posttranslational modifications on their function. These studies have implications in furthering our understanding of JAM in cancer and provide a paradigm for exploring additional roles of TJ proteins.
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JAMs are essential drivers of EMT in cancer metastasis, modulating morphology, migration, and cell polarity.
“they are essential drivers of EMT in the context of cancer metastasis, modulating morphology, migration, and cell polarity74.”
From Cell diversity and plasticity during atrioventricular heart valve EMTs (2023) · cites this paper as [74]
The JAM-A structure and function section says JAM-A induces EMT in some cancers, and the metastasis section links JAM-A to increased EMT in nasopharyngeal cancer. The paper also describes roles for JAMs in migration and polarity, but it does not establish that JAMs are essential drivers of EMT across cancer metastasis or specifically link them to the claimed morphological changes. Its Conclusion emphasizes that JAM-A can have both pro- and anti-tumorigenic roles. (LLM, conf=0.88)
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Cites
Initial steps of metastasis: Cell invasion and endothelial transmigration
van Zijl, F., Krupitza, G., & Mikulits, W. (2011) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2011.05.002 · Cited by 884 · see citing works
Junctional adhesion molecules (JAMs): more molecules with dual functions?
Ebnet, K., Suzuki, A., Ohno, S., & Vestweber, D. (2003) · Journal of Cell Science · doi:10.1242/jcs.00930 · Cited by 501 · see citing works
Loss of tight junction barrier function and its role in cancer metastasis
Martin, T. A., & Jiang, W. G. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.11.005 · Cited by 493 · see citing works
Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436 · see citing works
En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition
Aceto, N., Toner, M., Maheswaran, S., & Haber, D. A. (2015) · Trends in cancer · doi:10.1016/j.trecan.2015.07.006 · Cited by 275 · see citing works
Götte, M., Mohr, C. F., Koo, C.-Y., Stock, C. M., Vaske, A.-K., Viola, M., Ibrahim, S., Peddibhotla, S. S. D., Teng, Y. H.-F., Low, J.-Y., et al. (2010) · Oncogene · doi:10.1038/onc.2010.386 · Cited by 219 · see citing works
Endothelial Cell Junctional Adhesion Molecules
Reglero-Real, N., Colom, B., Bodkin, J. V., & Nourshargh, S. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307610 · Cited by 218 · see citing works
Mandell, K. J., Babbin, B. A., Nusrat, A., & Parkos, C. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412650200 · Cited by 198 · see citing works
CTC clusters in cancer progression and metastasis
Fabisiewicz, A., & Grzybowska, E. A. (2016) · Medical Oncology · doi:10.1007/s12032-016-0875-0 · Cited by 183 · see citing works
Ebnet, K. (2017) · Physiological Reviews · doi:10.1152/physrev.00004.2017 · Cited by 177 · see citing works
Severson, E. A., Lee, W. Y., Capaldo, C., Nusrat, A., & Parkos, C. A. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-10-1014 · Cited by 175 · see citing works
Naik, M. U., Naik, T. U., Suckow, A. T., Duncan, M. K., & Naik, U. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3057 · Cited by 149 · see citing works
Self-citationWoodfin, A., Reichel, C. A., Khandoga, A., Corada, M., Voisin, M.-B., Scheiermann, C., Haskard, D. O., Dejana, E., Krombach, F., & Nourshargh, S. (2007) · Blood · doi:10.1182/blood-2006-09-047431 · Cited by 149 · see citing works
JAM‐A expression positively correlates with poor prognosis in breast cancer patients
McSherry, E. A., McGee, S. F., Jirström, K., Doyle, E. M., Brennan, D. J., Landberg, G., Dervan, P. A., Hopkins, A. M., & Gallagher, W. M. (2009) · International Journal of Cancer · doi:10.1002/ijc.24498 · Cited by 139 · see citing works
Naik, M. U., Mousa, S. A., Parkos, C. A., & Naik, U. P. (2003) · Blood · doi:10.1182/blood-2003-04-1114 · Cited by 139 · see citing works
Self-citationRole of tight junctions in cell proliferation and cancer
González‐Mariscal, L., Lechuga, S., & Garay, E. (2007) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2007.01.001 · Cited by 135 · see citing works
Mandell, K. J., McCall, I. C., & Parkos, C. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309483200 · Cited by 134 · see citing works
McSherry, E. A., Brennan, K., Hudson, L., Hill, A. D. K., & Hopkins, A. M. (2011) · Breast Cancer Research · doi:10.1186/bcr2853 · Cited by 131 · see citing works
Veenstra, M., León‐Rivera, R., Li, M., Gama, L., Clements, J. E., & Berman, J. W. (2017) · mBio · doi:10.1128/mbio.01280-17 · Cited by 130 · see citing works
Monteiro, A. C., Sumagin, R., Rankin, C. R., Leoni, G., Mina, M. J., Reiter, D. M., Stehle, T., Dermody, T. S., Schaefer, S. A., Hall, R. A., et al. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-06-0298 · Cited by 129 · see citing works
Activation of human platelets by a stimulatory monoclonal antibody.
Kornecki, E., Walkowiak, B., Naik, U. P., & Ehrlich, Y. H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38776-9 · Cited by 127 · see citing works
Self-citationJAM-related proteins in mucosal homeostasis and inflammation
Luissint, A., Nusrat, A., & Parkos, C. A. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0421-0 · Cited by 118 · see citing works
JAM Family and Related Proteins in Leukocyte Migration (Vestweber Series)
Bradfield, P. F., Nourshargh, S., Aurrand‐Lions, M., & Imhof, B. A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147694 · Cited by 111 · see citing works
aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation
Iden, S., Misselwitz, S., Peddibhotla, S. S. D., Tuncay, H., Rehder, D., Gerke, V., Robenek, H., Suzuki, A., & Ebnet, K. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201104143 · Cited by 111 · see citing works
Sobocka, M. B., Sobocki, T., Banerjee, P., Weiss, C., Rushbrook, J. I., Norin, A. J., Hartwig, J. H., Salifu, M. O., MARKELL, M. S., Babińska, A., et al. (2000) · Blood · doi:10.1182/blood.v95.8.2600.008k28_2600_2609 · Cited by 108 · see citing works
Adachi, M., Hamazaki, Y., Kobayashi, Y., Itoh, M., Tsukita, S., Furuse, M., & Tsukita, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01505-08 · Cited by 92 · see citing works
Cooke, V. G., Naik, M. U., & Naik, U. P. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000234923.79173.99 · Cited by 90 · see citing works
Self-citationLathia, J. D., Li, M., Sinyuk, M., Alvarado, A. G., Flavahan, W. A., Stoltz, K., Rosager, A. M., Hale, J. S., Hitomi, M., Gallagher, J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.11.043 · Cited by 87 · see citing works
Self-citationJAM‐A regulates epithelial proliferation through Akt/β‐catenin signalling
Nava, P., Capaldo, C., Koch, S., Kolegraff, K. N., Rankin, C. R., Farkas, A. E., Feasel, M. E., Li, L., Addis, C. R., Parkos, C. A., et al. (2011) · EMBO Reports · doi:10.1038/embor.2011.16 · Cited by 87 · see citing works
Santoso, S., Orlova, V. V., Song, K., Sachs, U. J., Andrei‐Selmer, C., & Chavakis, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505059200 · Cited by 87 · see citing works
JAM-C Regulates Tight Junctions and Integrin-mediated Cell Adhesion and Migration
Mandicourt, G., Iden, S., Ebnet, K., Aurrand‐Lions, M., & Imhof, B. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605666200 · Cited by 85 · see citing works
A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis
Langer, H. F., Orlova, V. V., Xie, C., Kaul, S. C., Schneider, D., Lonsdorf, A. S., Sauter, M., Choi, E. Y., Dutoit, V., Pellegrini, M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2794 · Cited by 84 · see citing works
Thiagarajan, P. S., Hitomi, M., Hale, J. S., Alvarado, A. G., Otvos, B., Sinyuk, M., Stoltz, K., Wiechert, A. C., Mulkearns-Hubert, E. E., Jarrar, A., et al. (2015) · Stem Cells · doi:10.1002/stem.2021 · Cited by 82 · see citing works
Self-citationJunctional Adhesion Molecule (JAM) Is Phosphorylated by Protein Kinase C upon Platelet Activation
Ozaki, H., Ishii, K., Arai, H., Horiuchi, H., Kawamoto, T., Suzuki, H., & Kita, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3574 · Cited by 76 · see citing works
Leech, A. O., Cruz, R. G. B., Hill, A. D. K., & Hopkins, A. M. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.08.01 · Cited by 75 · see citing works
Junctional adhesion molecule-A: functional diversity through molecular promiscuity
Steinbacher, T., Kummer, D., & Ebnet, K. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2729-0 · Cited by 70 · see citing works
Murakami, M., Giampietro, C., Giannotta, M., Corada, M., Torselli, I., Orsenigo, F., Cocito, A., D’Ario, G., Mazzarol, G., Confalonieri, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021242 · Cited by 66 · see citing works
Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection
Kummer, D., & Ebnet, K. (2018) · Cells · doi:10.3390/cells7040025 · Cited by 65 · see citing works
Peddibhotla, S. S. D., Brinkmann, B., Kummer, D., Tuncay, H., Nakayama, M., Adams, R. H., Gerke, V., & Ebnet, K. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-06-0481 · Cited by 62 · see citing works
MicroRNA-495 induces breast cancer cell migration by targeting JAM-A
Cao, M., Nie, W., Li, J., Zhang, Y., Yan, X., Guan, X., Chen, X., Zen, K., Zhang, C., Jiang, X., et al. (2014) · Protein & Cell · doi:10.1007/s13238-014-0088-2 · Cited by 62 · see citing works
Tian, Y., Tian, Y., Zhang, W., Fang, W., Yang, J., Luo, X., Zhou, T. Y., Hou, B., Shen, Q., Deng, X.-B., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu230 · Cited by 60 · see citing works
Overexpression of JAM-A in Non-Small Cell Lung Cancer Correlates with Tumor Progression
Zhang, M., Luo, W., Huang, B., Liu, Z., Sun, L., Zhang, Q., Qiu, X., Xu, K., & Wang, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079173 · Cited by 60 · see citing works
Goetsch, L., Haeuw, J., Beau‐Larvor, C., Gonzalez, A., Zanna, L., Malissard, M., Lepecquet, A., Robert, A., Bailly, C., Broussas, M., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27772 · Cited by 60 · see citing works
Brennan, K., McSherry, E. A., Hudson, L., Kay, E. W., Hill, A., Young, L. S., & Hopkins, A. M. (2012) · Oncogene · doi:10.1038/onc.2012.276 · Cited by 53 · see citing works
Junctional Adhesion Molecule-C Promotes Metastatic Potential of HT1080 Human Fibrosarcoma
Fuse, C., Ishida, Y., Hikita, T., Asai, T., & Oku, N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608836200 · Cited by 52 · see citing works
Fan, S., Weight, C. M., Luissint, A., Hilgarth, R., Brazil, J. C., Ettel, M. G., Nusrat, A., & Parkos, C. A. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-08-0531 · Cited by 51 · see citing works
Cell Surface Proteomics Identifies Molecules Functionally Linked to Tumor Cell Intravasation
Conn, E. M., Madsen, M. A., Cravatt, B. F., Ruf, W., Deryugina, E. I., & Quigley, J. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803337200 · Cited by 50 · see citing works
Gutwein, P., Schramme, A., Voss, B., Abdel‐Bakky, M. S., Doberstein, K., Ludwig, A., Altevogt, P., Hansmann, M., Moch, H., Kristiansen, G., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.100 · Cited by 49 · see citing works
F11R Is a Novel Monocyte Prognostic Biomarker for Malignant Glioma
Pong, W. W., Walker, J., Wylie, T., Magrini, V. J., Luo, J. R., Emnett, R. J., Choi, J., Cooper, M. L., Griffith, M., Griffith, O. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077571 · Cited by 47 · see citing works
Self-citationFong, D., Spizzo, G., Mitterer, M., Seeber, A., Steurer, M., Gastl, G. A., Brosch, I., & Moser, P. L. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2381-8 · Cited by 46 · see citing works
JAM-A functions as a female microglial tumor suppressor in glioblastoma
Turaga, S. M., Silver, D. J., Bayık, D., Paouri, E., Peng, S., Lauko, A. J., Alban, T. J., Borjini, N., Stanko, S., Naik, U. P., et al. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa148 · Cited by 46 · see citing works
Self-citationThe Junctional Adhesion Molecule‐B regulates JAM‐C‐dependent melanoma cell metastasis
Arcangeli, M.-L., Frontera, V., Bardin, F., Piana, J. T., Chetaille, B., Adams, S., Adams, R. H., & Aurrand‐Lions, M. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.10.005 · Cited by 45 · see citing works
Junctional adhesion molecule 1 (JAM-1).
Naik, U. P., & Eckfeld, K. (2003) · PubMed · Cited by 42 · see citing works
Self-citationTenan, M., Aurrand‐Lions, M., Widmer, V., Alimenti, A., Burkhardt, K., Lazeyras, F., Belkouch, M., Hammel, P., Walker, P. R., Duchosal, M. A., et al. (2009) · Glia · doi:10.1002/glia.20941 · Cited by 40 · see citing works
Histone Deacetylase Inhibitors Enhance the Therapeutic Potential of Reovirus in Multiple Myeloma
Stiff, A. R., Caserta, E., Sborov, D. W., Nuovo, G. J., Mo, X. M., Schlotter, S. Y., Canella, A., Smith, E., Badway, J. A., Old, M. O., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0240-t · Cited by 40 · see citing works
Wang, Y., & Lui, W. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.04.016 · Cited by 40 · see citing works
Coordination of self-renewal in glioblastoma by integration of adhesion and microRNA signaling
Alvarado, A. G., Turaga, S. M., Sathyan, P., Mulkearns-Hubert, E. E., Otvos, B., Silver, D. J., Hale, J. S., Flavahan, W. A., Zinn, P. O., Sinyuk, M., et al. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov196 · Cited by 40 · see citing works
Self-citationN-glycosylation controls the function of junctional adhesion molecule-A
Scott, D. W., Tolbert, C. E., Graham, D. M., Wittchen, E. S., Bear, J. E., & Burridge, K. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-12-1604 · Cited by 38 · see citing works
Leech, A. O., Vellanki, S. H., Rutherford, E. J., Keogh, A., Jahns, H., Hudson, L., O’Donovan, N., Sabri, S., Abdulkarim, B., Sheehan, K. M., et al. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1064-1 · Cited by 38 · see citing works
Ghislin, S., Obino, D., Middendorp, S., Boggetto, N., Alcaïde‐Loridan, C., & Deshayes, F. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00856.x · Cited by 34 · see citing works
Bednarek, R., Selmi, A., Wojkowska, D. W., Karolczak, K., Popielarski, M., Stasiak, M., Salifu, M. O., Babińska, A., & Świątkowska, M. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05471-x · Cited by 34 · see citing works
Luissint, A., Williams, H. C., Kim, W., Flemming, S., Azcutia, V., Hilgarth, R., Leary, M. N. O., Denning, T. L., Nusrat, A., & Parkos, C. A. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0143-7 · Cited by 33 · see citing works
Doñate, C., Ody, C., McKee, T., Ruault-Jungblut, S., Fischer, N., Ropraz, P., Imhof, B. A., & Matthes, T. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1756 · Cited by 33 · see citing works
Elevated expression of JAM ‐A promotes neoplastic properties of lung adenocarcinoma
Magara, K., Takasawa, A., Osanai, M., Ota, M., Tagami, Y., Ono, Y., Takasawa, K., Murata, M., Hirohashi, Y., Miyajima, M., et al. (2017) · Cancer Science · doi:10.1111/cas.13385 · Cited by 32 · see citing works
Low junctional adhesion molecule A expression correlates with poor prognosis in gastric cancer
Huang, J., Xu, Y., Sun, Z., Wang, Z.-N., Zhu, Z., Song, Y., Luo, Y., Zhang, X. Z., & Xu, H. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.06.025 · Cited by 32 · see citing works
Leinster, D. A., Colom, B., Whiteford, J. R., Ennis, D. P., Lockley, M., McNeish, I. A., Aurrand‐Lions, M., Chavakis, T., Imhof, B. A., Balkwill, F. R., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-230441 · Cited by 31 · see citing works
Zhao, C., Wang, A., Lu, F., Chen, H., Fu, P., Zhao, X., & Chen, H. (2017) · Tumor Biology · doi:10.1177/1010428317691000 · Cited by 29 · see citing works
Junctional adhesion molecule C (JAM-C) dimerization aids cancer cell migration and metastasis
Garrido‐Urbani, S., Vonlaufen, A., Stalin, J., Grandis, M. D., Ropraz, P., Jemelin, S., Bardin, F., Scheib, H., Aurrand‐Lions, M., & Imhof, B. A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.01.008 · Cited by 28 · see citing works
Junctional adhesion molecule-A promotes proliferation and inhibits apoptosis of gastric cancer.
Ikeo, K., Oshima, T., Shan, J., Matsui, H., Tomita, T., Fukui, H., Watari, J., & Miwa, H. (2015) · PubMed · Cited by 28 · see citing works
Brüning, A., Stickeler, E., Diederich, D., Walz, L., Rohleder, H., Friese, K., & Runnebaum, I. B. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2370 · Cited by 28 · see citing works
Ody, C., Ruault-Jungblut, S., Cossali, D., Barnet, M., Aurrand‐Lions, M., Imhof, B. A., & Matthes, T. (2007) · Leukemia · doi:10.1038/sj.leu.2404689 · Cited by 27 · see citing works
Expression and prognostic value of JAM-A in gliomas
Rosager, A. M., Sørensen, M. D., Dahlrot, R. H., Boldt, H. B., Hansen, S., Lathia, J. D., & Kristensen, B. W. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2555-0 · Cited by 26 · see citing works
Self-citationJAM-C promotes lymphangiogenesis and nodal metastasis in non-small cell lung cancer
Hao, S., Yang, Y., Liu, Y., Yang, S., Wang, G., Xiao, J., & Liu, H. (2014) · Tumor Biology · doi:10.1007/s13277-014-1751-1 · Cited by 26 · see citing works
Vellanki, S. H., Cruz, R. G. B., Jahns, H., Hudson, L., Sette, G., Eramo, A., & Hopkins, A. M. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.09.032 · Cited by 25 · see citing works
Junctional adhesion molecules in angiogenesis
Tejal, U. N. (2007) · Frontiers in bioscience · doi:10.2741/2676 · Cited by 25 · see citing works
Grandis, M. D., Bardin, F., Fauriat, C., Zemmour, C., Elkaoutari, A., Sergé, A., Granjeaud, S., Pouyet, L., Montersino, C., Chretien, A., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1223 · Cited by 23 · see citing works
Orlandella, F. M., Mariniello, R. M., Iervolino, P. L. C., Auletta, L., Stefano, A. E. D., Ugolini, C., Greco, A., Mirabelli, P., Pane, K., Franzese, M., et al. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.23001 · Cited by 23 · see citing works
Upadhaya, P., Barhoi, D., Giri, A., Bhattacharjee, A., & Giri, S. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29115 · Cited by 22 · see citing works
Jam3 promotes migration and suppresses apoptosis of renal carcinoma cell lines
Li, X., Yin, A., Zhang, W., Zhao, F. L., Lv, J., Lv, J., & Sun, J. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3854 · Cited by 21 · see citing works
Jiang, X., Dai, B., & Feng, L. (2019) · Human Cell · doi:10.1007/s13577-019-00274-0 · Cited by 20 · see citing works
Expression of the coxsackie and adenovirus receptor in human lung cancers
Chen, Z., Wang, Q., Sun, J., Gu, A., Jin, M., Shen, Z., Qiu, Z., Wang, J., Wang, X., Zhan, Z., et al. (2013) · Tumor Biology · doi:10.1007/s13277-012-0342-2 · Cited by 17 · see citing works
Anti-JAM-C therapy eliminates tumor engraftment in a xenograft model of mantle cell lymphoma
Doñate, C., Kumar, A. V., Imhof, B. A., & Matthes, T. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1hi1114-549rr · Cited by 13 · see citing works
Boljević, I., Malisic, E. J., Marijana, M.-K., Irena, J., Bukumirić, Z., & Jankovic, R. N. (2019) · The International Journal of Biological Markers · doi:10.1177/1724600819850178 · Cited by 12 · see citing works
Naydenov, N. G., Joshi, S. K., Feygin, A., Saini, S., Litovchick, L., & Ivanov, A. I. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1496755 · Cited by 11 · see citing works
Proteomic analysis of the effects of cell culture density on the metastasis of breast cancer cells
Guo, M., Sun, M., Lan, J., Yan, L., Zhang, J., Hu, X., Xu, S., Mao, D., Yang, H., Liu, Y., et al. (2019) · Cell Biochemistry and Function · doi:10.1002/cbf.3377 · Cited by 11 · see citing works
Babińska, A., Clement, C. C., Li, Y., Wzorek, J., Przygodzki, T., Talar, M., Braun, M., Świątkowska, M., Ehrlich, Y. H., Kornecki, E., et al. (2020) · Data in Brief · doi:10.1016/j.dib.2020.105516 · Cited by 7 · see citing works
Flagged first, then by citations
2 of the 88 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cancer-Associated Angiogenesis: The Endothelial Cell as a Checkpoint for Immunological Patrolling
Solimando, A. G., Summa, S. D., Vacca, A., & Ribatti, D. (2020) · Cancers · doi:10.3390/cancers12113380 · Cited by 93 · see citing works
Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Schurhoff, N. A., & Toborek, M. J. (2023) · Molecular Brain · doi:10.1186/s13041-023-00997-0 · Cited by 91 · see citing works
Knol, J. C., Lyu, M., Böttger, F., Monteiro, M. N., Pham, T. V., Rolfs, F., Vallés‐Martí, A., Schelfhorst, T., Haas, R. R. D. G., Bijnsdorp, I. V., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.05.003 · Cited by 59 · see citing works
Yang, Z., Wang, W., Zhao, L., Wang, X., Gimple, R. C., Xu, L., Wang, Y., Rich, J. N., & Zhou, S. (2021) · Science Advances · doi:10.1126/sciadv.abb0737 · Cited by 56 · see citing works
JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism
Huang, W. C., Wang, B.-O., Hou, Y., Fu, Y., Cui, S., Zhu, J., Zhan, X.-Y., Li, R., Tang, W., Wu, J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158571 · Cited by 55 · see citing works
Zhang, T., Xia, C., Zheng, B., Hu, H., Jiang, L., Escobar, D., Zheng, B., Chen, T.-D., Li, J., Lv, G., et al. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad173 · Cited by 51 · see citing works
Díez-Sainz, E., Milagro, F. I., Aranaz, P., Riezu‐Boj, J. I., & Lorente‐Cebrián, S. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01023-0 · Cited by 39 · see citing works
Guan, Z., Lan, H., Cai, X., Zhang, Y., Liang, A., & Li, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.722917 · Cited by 38 · see citing works
The claudin–transcription factor signaling pathway
Sugimoto, K., & Chiba, H. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.1908109 · Cited by 36 · see citing works
Targeting nanoparticles to malignant tumors
Sharma, N., Bietar, K., & Stochaj, U. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188703 · Cited by 34 · see citing works
JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy
McGraw, J. M., Thelen, F., Hampton, E. N., Bruno, N. E., Young, T. S., Havran, W. L., & Witherden, D. A. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202644 · Cited by 34 · see citing works
SerpinB3 drives cancer stem cell survival in glioblastoma
Lauko, A. J., Volovetz, J., Turaga, S. M., Bayık, D., Silver, D. J., Mitchell, K., Mulkearns-Hubert, E. E., Watson, D. C., Desai, K., Midha, M. D., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111348 · Cited by 31 · see citing works
Self-citationOccludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4
Yang, F., Liu, X., He, J., Xian, S., Yang, P., Mai, Z., Li, M., Liu, Y., & Zhang, X. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17257 · Cited by 30 · see citing works
eIF3a Regulates Colorectal Cancer Metastasis via Translational Activation of RhoA and Cdc42
Mei, C., Liu, C., Gao, Y., Dai, W., Zhang, W., Li, X., & Liu, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.794329 · Cited by 26 · see citing works
Timpanaro, A., Piccand, C., Uldry, A., Bode, P. K., Dzhumashev, D., Sala, R., Heller, M., Rössler, J. K., & Bernasconi, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032601 · Cited by 23 · see citing works
You, X., Li, M., Cai, H., Zhang, W., Hong, Y., Gao, W., Liu, Y., Liang, X., Wu, T., Chen, F., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.736929 · Cited by 21 · see citing works
Wu, Q., Li, R., Wang, Q., Zhang, M., Liu, T., & Qu, Y.-Q. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03457-w · Cited by 17 · see citing works
New solutions of time-fractional cancer tumor models using modified He-Laplace algorithm
Qayyum, M., Ahmad, E., & Ali, M. R. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34160 · Cited by 14 · see citing works
Cell diversity and plasticity during atrioventricular heart valve EMTs
Lotto, J., Cullum, R., Drissler, S., Arostegui, M., Garside, V. C., Fuglerud, B. M., Clement-Ranney, M., Thakur, A., Underhill, T. M., & Hoodless, P. A. (2023) · Nature Communications · doi:10.1038/s41467-023-41279-6 · Cited by 13 · see citing works
Xiong, R., Long, Q., Zhang, X., Xu, J., Liu, Y., Xiong, L., Yang, S., Feng, G., Song, G., & Liu, K. (2022) · Human Cell · doi:10.1007/s13577-022-00806-1 · Cited by 13 · see citing works
A JAM-A–tetraspanin–αvβ5 integrin complex regulates contact inhibition of locomotion
Kummer, D., Steinbacher, T., Thölmann, S., Schwietzer, M. F., Hartmann, C., Horenkamp, S., Demuth, S., Peddibhotla, S. S. D., Brinkmann, F., Kemper, B., et al. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202105147 · Cited by 13 · see citing works
Jiang, Y., Hu, Z., Wei, Y., Su, Y., Yang, Y., Aikedai, A., Liao, W., Wei, Y., Zeng, X., Qian, K., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123908 · Cited by 12 · see citing works
Influencing inter-cellular junctions with nanomaterials
Wang, J., Zhang, G., Xing, K., Wang, B., Liu, Y., Xue, Y., Liu, S., & Leong, D. T. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103372 · Cited by 12 · see citing works
Wang, N., Chen, M., Wu, M., Liao, Y., Xia, Q., Cai, Z., He, C., Tang, Q., Zhou, Y., Zhao, L., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.12.040 · Cited by 12 · see citing works
Cerebral biomimetic nano-drug delivery systems: A frontier strategy for immunotherapy
Tian, H., Yao, J., Ba, Q., Meng, Y., Cui, Y., Quan, L., Gong, W., Wang, Y., Yang, Y., Yang, M., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.058 · Cited by 11 · see citing works
miR-152–3p facilitates cell adhesion and hepatic metastases in colorectal cancer via targeting AQP11
Zhu, X., Jin, X., Li, Z., Chen, X., & Zhao, J. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154389 · Cited by 11 · see citing works
Emerging roles of transmembrane‐type tight junction proteins in cancers
Takasawa, A., Takasawa, K., Murata, M., Osanai, M., & Sawada, N. (2023) · Pathology International · doi:10.1111/pin.13349 · Cited by 10 · see citing works
JAM3 promotes cervical cancer metastasis by activating the HIF-1α/VEGFA pathway
Peng, J., Chen, Y., & Yin, A. (2024) · BMC Women s Health · doi:10.1186/s12905-024-03127-7 · Cited by 10 · see citing works
Luissint, A., Fan, S., Nishio, H., Lerário, A. M., Miranda, J., Hilgarth, R., Cook, J., Nusrat, A., & Parkos, C. A. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.09.012 · Cited by 10 · see citing works
Blood–brain barrier and brain structural changes in lung cancer patients with non-brain metastases
Zhang, D.-F., Ma, H., Yang, G.-J., Zhang, Z.-P., He, Y., Feng, M., Shan, B.-C., Xu, X.-F., Ding, Y.-Y., & Cheng, Y.-Q. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1015011 · Cited by 9 · see citing works
Visualizing cellular interactions: intravital imaging in tumor microenvironment
Li, S., Liu, L., Shan, J., & Cheng, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1630658 · Cited by 9 · see citing works
CAR Co-Operates With Integrins to Promote Lung Cancer Cell Adhesion and Invasion
Owczarek, C., Zapater, E. O., Kim, J., Papaevangelou, E., Santis, G., & Parsons, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.829313 · Cited by 9 · see citing works
Qi, J., Zhu, H., Li, Y., Guan, X., He, Y., Ren, G., Guo, Q., Liu, L., Gu, Y., Dong, X., et al. (2023) · Small Methods · doi:10.1002/smtd.202300730 · Cited by 8 · see citing works
Qayyum, M., & Ahmad, E. (2024) · Physica Scripta · doi:10.1088/1402-4896/ad7f98 · Cited by 7 · see citing works
Romano, E., Rosa, I., Fioretto, B. S., Matucci‐Cerinic, M., & Manetti, M. (2022) · Life · doi:10.3390/life12111790 · Cited by 7 · see citing works
Ether Derivatives of Naringenin and Their Oximes as Factors Modulating Bacterial Adhesion
Duda-Madej, A., Kozłowska, J., Baczyńska, D., & Krzyżek, P. (2023) · Antibiotics · doi:10.3390/antibiotics12061076 · Cited by 7 · see citing works
γδ T cell costimulatory ligands in antitumor immunity
McGraw, J. M., & Witherden, D. A. (2022) · Exploration of Immunology · doi:10.37349/ei.2022.00038 · Cited by 7 · see citing works
The most likely but largely ignored triggering factor for breast (or all) cancer invasion
Man, Y., Mannion, C. M., Stojadinovic, A., Peoples, G. E., Cho, W. C. S., Fu, S. W., Tan, X., Hsiao, Y.-H., Liu, A., Semczuk, A., et al. (2023) · Journal of Cancer · doi:10.7150/jca.82291 · Cited by 6 · see citing works
Towards a structural and functional analysis of the immunoglobulin-fold proteome
Tawfeeq, C., Song, J., Khaniya, U., Madej, T., Wang, J., Youkharibache, P., & Abrol, R. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.11.002 · Cited by 5 · see citing works
Uno, K., Kubota, E., Mori, Y., Nishigaki, R., Kojima, Y., Kanno, T., Sasaki, M., Fukusada, S., Sugimura, N., Tanaka, M., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123489 · Cited by 5 · see citing works
Mendoza, C., & Mizrachi, D. (2022) · Biomedicines · doi:10.3390/biomedicines10020381 · Cited by 5 · see citing works
IgSF11–RAP1 signaling promotes cell migration and invasion of cutaneous melanoma
Kobayashi, Y., Sugimoto, K., Ishibashi, M., Kobayashi, M., Igari, S., Kitamura, S., Yamamoto, T., Hashimoto, Y., & Chiba, H. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02245-5 · Cited by 4 · see citing works
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Ren, T., Zheng, Y., Liu, F., Liu, C., Zhang, B., Ren, H., Gao, X., Wei, Y., Sun, Q., & Huang, H. (2024) · Biomedicines · doi:10.3390/biomedicines12071423 · Cited by 4 · see citing works
Jia, Y., Liu, J., Shi, J., Zhang, C., Wang, X., Zhao, L., Lou, Y., Guan, X., & Huangfu, H. (2024) · Oncology Reports · doi:10.3892/or.2024.8861 · Cited by 3 · see citing works
Weidle, U. H., & Birzele, F. (2024) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20442 · Cited by 3 · see citing works
JAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathway
Chen, M., Li, W., Du, Y., Zhao, Y., Guo, Y., Li, Y., Wang, X., Huang, L., Zeng, X., Zhang, Y., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.05.037 · Cited by 2 · see citing works
Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion
Ebnet, K., & Aurrand‐Lions, M. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05829-z · Cited by 3 · see citing works
Zhou, S., Guo, Z., Dong, Q., Li, X., Jiao, Y., Deng, X., Hao, H., & Han, S. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157673 · Cited by 2 · see citing works
Lipocalin 2 orchestrates resistance to ferroptosis via AXL
Wang, S. Z., Timken, J. P., Hong, E. S., Kaur, S., Newby, E., Kay, K. E., Mulkearns-Hubert, E. E., Silver, D. J., Lee, J., Rubin, J. B., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116965 · Cited by 2 · see citing works
Self-citationSichani, S. B., Khorshid, M., Yongabi, D., Urbán, C. T., Schreurs, M., Verstrepen, K. J., Lettinga, M. P., Schöning, M. J., Lieberzeit, P. A., & Wagner, P. (2024) · ACS Sensors · doi:10.1021/acssensors.4c00732 · Cited by 2 · see citing works
Kamińska, K., Świderska, B., Malinowska, A., & Grzesiak, M. (2024) · Journal of Proteomics · doi:10.1016/j.jprot.2024.105318 · Cited by 2 · see citing works
Spatial transcriptomic profiling of human retinoblastomaPreprint
Wang, L., Hung, S. S. C., Urrutia-Cabrera, D., Kong, R. C. K., Staffieri, S. E., Ludlow, L. E. A., Lau, X., Wang, P., Hewitt, A. W., & Wong, R. C. B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.05.578886 · Cited by 2 · see citing works
Dynamic uterine microenvironment drives endometrial adenocarcinoma carcinogenesis and progression
Conrad, L. B., Yin, S., Feng, B., King, L., Hobson, B., Andersen, K. E., Coté, J. J., Farias‐Eisner, R., Xia, J., & Fu, Y. (2026) · Communications Biology · doi:10.1038/s42003-026-10185-0 · Cited by 1 · see citing works
Tight Junction Proteins as Emerging Drug Targets: Expanding the Horizons from Inflammation to Cancer
Garimella, S. V., Roy, R., Gampa, S. C., & Pandrangi, S. L. (2023) · Springer eBooks · doi:10.1007/978-981-99-2415-8_5 · Cited by 1 · see citing works
Micro RNA-175 Targets Claudin-1 to Inhibit Madin–Darby Canine Kidney Cell Adhesion
Li, X., Ma, F., Wang, S., Tang, T., Ma, L., Qiao, Z., Ma, Z., Wang, J., & Liu, Z. (2024) · Genes · doi:10.3390/genes15101333 · Cited by 1 · see citing works
Blackler, G., Klapak, J. D., Guo, Q., Philpott, H. T., Jiang, H., Ocica, D., Sordo, L. D., Fiset, B., Walsh, L. A., & Appleton, C. T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.26.615231 · Cited by 1 · see citing works
Calcium Binding Protein S100A16 Expedites Proliferation, Invasion and EMT Process in Gastric CancerPreprint
You, X., Li, M., Cai, H., Zhang, W., Hong, Y., Gao, W., Liu, Y., Liang, X., Wu, T., Chen, F., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-674611/v1
Day-Walsh, P. E., Keeble, B., Pirabagar, G., Fountain, S. J., & Kroon, P. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158646
Tight Junctions and Prostate Cancer
Soini, Y. (2022) · Trends journal of sciences research · doi:10.31586/wjcor.2022.498
Shaaban, I. O. A., Sultan, H. K., Sultan, M., Gammal, M. M. A. E., & Balbaa, O. A. (2023) · The Egyptian Journal of Haematology · doi:10.4103/ejh.ejh_55_23
Li, B., Zhou, J., Ding, K., Liu, S., Zhang, L., Zeng, B., Yuan, H., Zuo, P., Wang, C., Li, S., et al. (2025) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2024.77
Tuppurainen, H., Nätynki, M., Laurila, N., Pylkäs, K., Winqvist, R., & Peltoketo, H. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152402
Li, L., Qin, W., & Xie, J. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01526j
Additional file 2 of JAM3 promotes cervical cancer metastasis by activating the HIF-1α/VEGFA pathway
Peng, J., Chen, Y., & Yin, A. (2024) · Figshare · doi:10.6084/m9.figshare.25853182
Wu, Q., Li, R., Wang, Q.-X., Zhang, M.-Y., Liu, T.-T., & Qu, Y.-Q. (2022) · Figshare · doi:10.6084/m9.figshare.20024749
Additional file 1 of JAM3 promotes cervical cancer metastasis by activating the HIF-1α/VEGFA pathway
Peng, J., Chen, Y., & Yin, A. (2024) · Figshare · doi:10.6084/m9.figshare.25853032
Zhang, P., Chen, Y., Yao, L., Dai, X., Qin, Z., Qin, Z., Gao, T., & Zhang, J. (2025) · Critical Public Health · doi:10.1080/09581596.2025.2603520
The role of Junctional Adhesion Molecule-A (JAM-A) in breast cancer metastasis.
Gawryś, K., Bednarek, R., & Świątkowska, M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11675-4 · Cited by 1 · see citing works
Computational mapping of antibody-receptor energy landscapes to predict internalizationPreprint
Llombart, P. B., Nieto‐Jiménez, C., Pandiella, A., Ocaña, A., & Espinosa, J. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.13.711720
Zhang, Y., Yang, B., Hou, X., Ming, W., Jin, X., Chen, G., Chen, D., & Zhang, W. (2026) · Cancer Research · doi:10.1158/0008-5472.can-25-4749
Zhuang, Y., Fu, C., Guo, Z., Xu, Y., Zhou, J., Ni, H., & Zhang, A. (2026) · Renal Failure · doi:10.1080/0886022x.2026.2736906
Proteomic and Metabolomic Analyses of Lung Squamous Cell Carcinoma
Mo, Y., Lin, L., Zhang, J., Li, Q., & 李道传 (2026) · Biomedicines · doi:10.3390/biomedicines14102389
- Authors
- Lauko, A., Mu, Z., Gutmann, D. H., Naik, U. P., & Lathia, J. D.
- Affiliations
- Cleveland Clinic (US)
- Thomas Jefferson University (US)
- Washington University in St. Louis (US)
- Corresponding author
- Naik, Ulhas P.
- Lathia, Justin D.
- Venue
- Cancer Research
- Published
- 2020-11-13
- Volume
- 80
- Issue
- 22
- Pages
- 4878-4885
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC7669553
- OpenAlex
- W3049205015
- Cited by
- 72
- References
- 88
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 18 · 2023: 12 · 2022: 16 · 2021: 6 · 2020: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01 NS109742, NS089641, NS083629, NS117104)
- NINDS (1-R35-NS07211-01, 1-R01-CA214146-01)
- NHLBI (2R0HL119374)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- junctional adhesion molecules, tight junction proteins, JAM-A, JAM-C, tumor progression, metastasis, cancer stem cells, epithelial-mesenchymal transition, apoptosis inhibition, cell proliferation, tumor microenvironment, post-translational modification, intracellular signaling, cell-cell interactions
- MeSH terms
- Breast Neoplasms, Cell Adhesion, Cell Communication, Cell Movement, Female, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Structure-Activity Relationship, Apoptosis, Disease Progression, Receptor, ErbB-2, Erb-b2 Receptor Tyrosine Kinases, Tight Junctions, Tumor Suppressor Proteins, Cell Proliferation, Tumor Microenvironment, Junctional Adhesion Molecules, Junctional Adhesion Molecule A, Junctional Adhesion Molecule C
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