Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Open accessPublished version of a preprint
Abstract
Cooperation between primary malignant cells and stromal cells can mediate the establishment of lung metastatic niches. Here, we characterized the landscape of cell populations in the tumor microenvironment in treatment-naïve osteosarcoma using single-cell RNA sequencing and identified a stem cell–like cluster with tumor cell–initiating properties and prometastatic traits. CXCL14 was specifically enriched in the stem cell–like cluster and was also significantly upregulated in lung metastases compared with primary tumors. CXCL14 induced stromal reprogramming and evoked a malignant phenotype in fibroblasts to form a supportive lung metastatic niche. Binding of CXCL14 to heterodimeric integrin α11β1 on fibroblasts activated actomyosin contractility and matrix remodeling properties. CXCL14-stimulated fibroblasts produced TGFβ and increased osteosarcoma invasion and migration. mAbs targeting the CXCL14-integrin α11β1 axis inhibited fibroblast TGFβ production, enhanced CD8+ T cell–mediated antitumor immunity, and suppressed osteosarcoma lung metastasis. Taken together, these findings identify cross-talk between osteosarcoma cells and fibroblasts that promotes metastasis and demonstrate that targeting the CXCL14-integrin α11β1 axis is a potential strategy to inhibit osteosarcoma lung metastasis. Significance: Cooperation between stem-like osteosarcoma cells and fibroblasts mediated by a CXCL14-integrin α11β1 axis creates a tumor-supportive lung metastatic niche and represents a therapeutic target to suppress osteosarcoma metastasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764 · see citing works
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
Eisenhauer, E. A., Therasse, P., Bogaerts, J., Schwartz, L. H., Sargent, D., Ford, R., Dancey, J., Arbuck, S., Gwyther, S., Mooney, M., et al. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.10.026 · Cited by 29,534 · see citing works
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174 · see citing works
Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314 · see citing works
UniProt: the universal protein knowledgebase in 2021
The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Agivetova, R., Ahmad, S., Alpi, E., Bowler-Barnett, E. H., Britto, R., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa1100 · Cited by 6,372 · see citing works
TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data
Colaprico, A., Silva, T. C., Olsen, C., Garofano, L., Cava, C., Garolini, D., Sabedot, T. S., Malta, T. M., Pagnotta, S. M., Castiglioni, I., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1507 · Cited by 4,137 · see citing works
A framework for advancing our understanding of cancer-associated fibroblasts
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863 · see citing works
Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors
Haghverdi, L., Lun, A. T. L., Morgan, M. D., & Marioni, J. C. (2018) · Nature Biotechnology · doi:10.1038/nbt.4091 · Cited by 2,416 · see citing works
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
Nagarsheth, N., Wicha, M. S., & Zou, W. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.49 · Cited by 2,196 · see citing works
Mechanotransduction and extracellular matrix homeostasis
Humphrey, J. D., Dufresne, E. R., & Schwartz, M. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3896 · Cited by 2,187 · see citing works
Humphries, J. D., Byron, A., & Humphries, M. J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03098 · Cited by 1,711 · see citing works
Every step of the way: integrins in cancer progression and metastasis
Hamidi, H., & Ivaska, J. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0038-z · Cited by 1,493 · see citing works
Tawbi, H. A., Burgess, M., Bolejack, V., Van Tine, B. A., Schuetze, S. M., Hu, J., D'Angelo, S., Attia, S., Riedel, R. F., Priebat, D. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30624-1 · Cited by 1,452 · see citing works
Self-citationTranslational biology of osteosarcoma
Kansara, M., Teng, M. W., Smyth, M. J., & Thomas, D. M. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3838 · Cited by 1,294 · see citing works
Su, S., Chen, J., Yao, H., Liu, J., Yu, S., Lao, L., Wang, M., Luo, M., Xing, Y., Chen, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.01.009 · Cited by 1,230 · see citing works
Clinical and therapeutic relevance of cancer-associated fibroblasts
Chen, Y., McAndrews, K. M., & Kalluri, R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00546-5 · Cited by 1,230 · see citing works
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25
Yang, L., Liu, Q., Zhang, X., Liu, X., Zhou, B., Chen, J., Huang, D., Li, J., Li, H., Chen, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2394-6 · Cited by 988 · see citing works
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
Lawson, D. A., Bhakta, N. R., Kessenbrock, K., Prummel, K. D., Yu, Y., Takai, K., Zhou, A. Y., Eyob, H., Balakrishnan, S., Wang, C., et al. (2015) · Nature · doi:10.1038/nature15260 · Cited by 894 · see citing works
Advancing therapy for osteosarcoma
Gill, J., & Gorlick, R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00519-8 · Cited by 876 · see citing works
Non-Smad Signaling Pathways of the TGF-β FamilyPreprint
Zhang, Y. E. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022129 · Cited by 699 · see citing works
Zhou, Y., Yang, D., Yang, Q., Lv, X., Huang, W., Zhou, Z., Wang, Y., Zhang, Z., Yuan, T., Ding, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20059-6 · Cited by 672 · see citing works
Kuo, J., Han, X., Hsiao, C.-T., Yates, J. R., & Waterman, C. M. (2011) · Nature Cell Biology · doi:10.1038/ncb2216 · Cited by 591 · see citing works
Metastasis-Initiating Cells and Ecosystems
Massagué, J., & Ganesh, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0010 · Cited by 372 · see citing works
Shen, Y., Wang, X., Lu, J., Salfenmoser, M., Wirsik, N. M., Schleußner, N., Imle, A., Valls, A. F., Radhakrishnan, P., Liang, J., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.005 · Cited by 337 · see citing works
Self-citationDavis, K. L., Fox, E., Merchant, M. S., Reid, J. M., Kudgus, R. A., Liu, X., Minard, C. G., Voss, S., Berg, S. L., Weigel, B. J., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30023-1 · Cited by 337 · see citing works
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
Fumagalli, A., Oost, K. C., Kester, L. A., Morgner, J., Bornes, L., Bruens, L., Spaargaren, L., Azkanaz, M., Schelfhorst, T., Beerling, E., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.02.008 · Cited by 321 · see citing works
Ji, Q., Zhou, L., Sui, H. X., Yang, L., Wu, X., Song, Q., Jia, R., Li, R., Sun, J., Wang, Z., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14869-x · Cited by 269 · see citing works
Sheng, G., Gao, Y., Yong, Y., & Wu, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.780264 · Cited by 202 · see citing works
Navab, R., Strumpf, D., To, C., Pasko, E., Kim, K. S., Park, C., Hai, J., Liu, J., Jonkman, J. E. N., Barczyk, M., et al. (2015) · Oncogene · doi:10.1038/onc.2015.254 · Cited by 190 · see citing works
Pein, M., Insua‐Rodríguez, J., Hongu, T., Riedel, A., Meier, J., Wiedmann, L., Decker, K., Essers, M. A. G., Sinn, H., Spaich, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15188-x · Cited by 189 · see citing works
Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
Baglio, S. R., Lagerweij, T., Pérez-Lanzón, M., Ho, X. D., Léveillé, N., Melo, S. A., Cleton-Jansen, A.-M., Jordanova, E. S., Roncuzzi, L., Greco, M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2726 · Cited by 187 · see citing works
Augsten, M., Sjöberg, E., Frings, O., Vorrink, S. U., Frijhoff, J., Olsson, E., Borg, Å., & Östman, A. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2740 · Cited by 167 · see citing works
Shani, O., Vorobyov, T., Monteran, L., Lavie, D., Cohen, N., Raz, Y., Tsarfaty, G., Avivi, C., Barshack, I., & Erez, N. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2116 · Cited by 153 · see citing works
Carracedo, S., Lü, N., Popova, S. N., Jonsson, R., Eckes, B., & Gullberg, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078766 · Cited by 145 · see citing works
Germain, P., Sonrel, A., & Robinson, M. D. (2020) · Genome biology · doi:10.1186/s13059-020-02136-7 · Cited by 139 · see citing works
IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling
Lu, J., Song, G., Tang, Q., Zou, C., Han, F., Zhao, Z., Yong, B., Yin, J., Xu, H., Xie, X., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78437 · Cited by 122 · see citing works
Self-citationSjöberg, E., Meyrath, M., Milde, L., Herrera, M., Lövrot, J., Hägerstrand, D., Frings, O., Bartish, M., Rolny, C., Sonnhammer, E. L. L., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1294 · Cited by 116 · see citing works
Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment
Brown, N. F., & Marshall, J. F. (2019) · Cancers · doi:10.3390/cancers11091221 · Cited by 116 · see citing works
Mitochondrial remodeling and ischemic protection by G protein–coupled receptor 35 agonists
Wyant, G. A., Yu, W., Doulamis, I. P., Nomoto, R. S., Saeed, M. Y., Duignan, T., McCully, J. D., & Kaelin, W. G. (2022) · Science · doi:10.1126/science.abm1638 · Cited by 111 · see citing works
Zhang, H., Wu, H., Zheng, J., Yu, P., Xu, L., Jiang, P., Gao, J., Wang, H., & Zhang, Y. (2012) · Stem Cells · doi:10.1002/stem.1298 · Cited by 109 · see citing works
Liu, W., Hu, H., Shao, Z., Lv, X., Zhang, Z., Deng, X., Song, Q., Han, Y. N., Guo, T., Xiong, L., et al. (2023) · Bone Research · doi:10.1038/s41413-022-00237-6 · Cited by 101 · see citing works
HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk
Wang, Y., Weng, X., Wang, L., Hao, M., Li, Y., Hou, L., Liang, Y., Wu, T., Yao, M., Lin, G., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99974 · Cited by 88 · see citing works
Self-citationIL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis
Gross, A. C., Cam, H., Phelps, D. A., Saraf, A. J., Bid, H. K., Cam, M., London, C. A., Winget, S. A., Arnold, M. A., Brandolini, L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99791 · Cited by 82 · see citing works
Chemokine CXCL14; a double-edged sword in cancer development
Shabgah, A. G., Al‐qaim, Z. H., Markov, A. A., Yumashev, A. V., Ezzatifar, F., Ahmadi, M., Hayat, S. M. G., & Navashenaq, J. G. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107681 · Cited by 80 · see citing works
Hughes, R. M., Simons, B. W., Khan, H., Miller, R., Kugler, V., Torquato, S., Theodros, D., Haffner, M. C., Lotan, T. L., Huang, J., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2931 · Cited by 76 · see citing works
Fujita, M., Takada, Y. K., & Takada, Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200889 · Cited by 65 · see citing works
Metastasis-associated fibroblasts: an emerging target for metastatic cancer
Wang, Z., Liu, J., Huang, H., Ye, M., Li, X., Wu, R., Liu, H., & Song, Y. (2021) · Biomarker Research · doi:10.1186/s40364-021-00305-9 · Cited by 61 · see citing works
Self-citationLü, N., Carracedo, S., Ranta, J., Heuchel, R. L., Soininen, R., & Gullberg, D. (2009) · Matrix Biology · doi:10.1016/j.matbio.2009.11.003 · Cited by 52 · see citing works
G enetic and clonal dissection of osteosarcoma progression and lung metastasis
Xu, H., Zhu, X., Bao, H., Shek, T. W., Huang, Z., Wang, Y., Wu, X., Wu, Y., Chang, Z., Wu, S., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31389 · Cited by 51 · see citing works
Self-citationAdaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
Zhang, W., Zhao, J.-M., Lin, J., Hu, C.-Z., Zhang, J., YANG, W.-L., Zhang, J., Zhang, J., & Zhu, J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.103 · Cited by 39 · see citing works
Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets
Bayık, D., Bartels, C. F., Lovrenert, K., Watson, D. C., Zhang, D., Kay, K. E., Lee, J., Lauko, A. J., Johnson, S., Lo, A., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3840 · Cited by 36 · see citing works
Zhang, Z., Ji, W., Huang, J., Zhang, Y., Zhou, Y., Zhang, J., Dong, Y., Yuan, T., Yang, Q., Ding, X., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1072 · Cited by 33 · see citing works
A novel prognostic model for osteosarcoma using circulating CXCL 10 and FLT 3 LG
Flores, R. J., Kelly, A. J., Li, Y., Nakka, M., Barkauskas, D. A., Krailo, M., Wang, L. L., Perlaky, L., Lau, C. C., Hicks, J. M., et al. (2016) · Cancer · doi:10.1002/cncr.30272 · Cited by 31 · see citing works
Lin, X., Dong, R., Diao, S., Yu, G., Wang, L., Li, J., & Fan, Z. (2017) · Cell Biology International · doi:10.1002/cbin.10757 · Cited by 31 · see citing works
Integrin α11β1: A Major Collagen Receptor on Fibroblastic Cells
Zeltz, C., Lü, N., & Gullberg, D. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-9153-3_5 · Cited by 24 · see citing works
Mukhopadhyay, N. K., Gilchrist, D., Gordon, G. J., Chen, C., Bueno, R., Lu, M. L., Salgia, R., Sugarbaker, D. J., & Jaklitsch, M. T. (2004) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2004.01.042 · Cited by 22 · see citing works
Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors
Fujiwara, S., Kawamoto, T., Kawakami, Y., Koterazawa, Y., Hara, H., Takemori, T., Kitayama, K., Yahiro, S., Kakutani, K., Matsumoto, T., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01944-9 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Advances on immunotherapy for osteosarcoma
Yu, S., & Yao, X. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02105-9 · Cited by 270 · see citing works
“The interaction of osteosarcoma cells expressing CXCL14 and fibroblasts expressing integrin α11β1 promotes metastasis and demonstrate that targeting the CXCL14-integrin α11β1 axis is a potential strategy to inhibit osteosarcoma lung metastasis [52].”
BackgroundWang, X., Luo, X., Xiao, R., Liu, X., Zhou, F., Jiang, D., Bai, J., Cui, M., You, L., & Yupei, Z. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02334-4 · Cited by 57 · see citing works
Self-citationYu, G., Corn, P. G., Mak, C. S. L., Liang, X., Zhang, M., Troncoso, P., Song, J. H., Lin, S.-C., Song, X., Liu, J., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402903121 · Cited by 42 · see citing works
Luo, T., Fan, Z., Zeng, A., Wang, A., Pan, Y., Xu, Y., Chen, H., Chen, W., Nie, D., Lin, J., et al. (2024) · Advanced Science · doi:10.1002/advs.202410427 · Cited by 38 · see citing works
Self-citationZou, Q.-M., Zhou, X., Lai, J., Zhou, H., Su, J., Zhang, Z., Zhuang, X.-S., Liu, L., Yuan, R., Li, S., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103460 · Cited by 34 · see citing works
Self-citationShi, S., Ou, X., Liu, C., Li, R., Zheng, Q., & Hu, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1518664 · Cited by 35 · see citing works
Tao, J., Gu, Y., Zhang, Z., Weng, G., Liu, Y., Ren, J., Shi, Y., Qiu, J., Wang, Y., Su, D., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03201-w · Cited by 29 · see citing works
Self-citationEmerging immunotherapies in osteosarcoma: from checkpoint blockade to cellular therapies
Han, Z., Chen, G., & Wang, D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1579822 · Cited by 23 · see citing works
Xu, W., Yang, H., Xu, K., Zhu, A., Hall, S. R. R., Jia, Y., Zhao, B., Zhang, E., Liu, G., Xu, J., et al. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70281 · Cited by 18 · see citing works
The tumor microenvironment of metastatic osteosarcoma in the human and canine lung
McGee, L. E., Pereira, J. D. S., McEachron, T. A., Mazcko, C. N., LeBlanc, A. K., & Beck, J. A. (2025) · Communications Biology · doi:10.1038/s42003-025-07992-2 · Cited by 18 · see citing works
Targeting OxLDL-mediated CD36 + CAF reprogramming potentiates PD-1 immunotherapy in osteosarcoma
Zeng, A., Chen, H., Luo, T., Chen, W., Song, Y., Xu, Y., Chen, Z., Tang, Q., Zhu, X., Deng, C., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02516-2 · Cited by 11 · see citing works
Self-citationDecoding osteosarcoma from heterogeneity to precision therapy
Xu, Y., Bai, Y., Yang, F., Yang, B., Huang, Z., Su, L., & Peng, K. (2025) · Discover Oncology · doi:10.1007/s12672-025-04256-7 · Cited by 9 · see citing works
Self-citationLi, B., Su, S., Yuan, S., Chen, D., Zhang, Q., Li, Q., Lin, X., Liang, X., Guan, W., & Zhang, S. (2025) · Research · doi:10.34133/research.0767 · Cited by 7 · see citing works
Lv, Y., Duan, T., Song, J., Liu, S., Zhou, Z., Ba, Y., Weng, S., Zuo, A., Xu, H., Luo, P., et al. (2026) · 癌症：英文版 · doi:10.34133/cancomm.0002 · Cited by 7 · see citing works
Self-citationShi, R., Ran, L., Li, B., Tian, Y., Guo, W., Jin, S., & Zhao, W. (2025) · Discover Oncology · doi:10.1007/s12672-025-02934-0 · Cited by 6 · see citing works
Qiu, Y., Pu, C., Wang, C., & Quan, Z. (2025) · Cancers · doi:10.3390/cancers17172928 · Cited by 4 · see citing works
Yin, S., Liu, W., Gao, C., Li, C., & Wu, J. (2026) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2025.2611582 · Cited by 4 · see citing works
Hsu, C., Alkhathami, A. G., ahmed, T. A., Chandra, M., Mohammed, J. S., Malathi, H., Sah, K. K., Chauhan, A. S., iwadi, A., & Ali, A. F. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114612 · Cited by 4 · see citing works
Xu, P., Yuan, J., Li, K., Wang, Y., Wu, Z., Zhao, J., Li, T., Wu, T., Miao, X., He, D., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-76841-9 · Cited by 3 · see citing works
Dai, Z., Xie, P., Bai, X., Liu, T., Guo, X., Kuang, L., Mu, P., & Lu, F. (2025) · Cancer Science · doi:10.1111/cas.70138 · Cited by 2 · see citing works
The lung pre‐metastatic niche in osteosarcoma: Mechanism and therapeutic intervention
Wang, D., Liu, T., Yin, B., Chang, Y., Hyon-U, P., Zhang, Y., & Li, H. (2025) · International Journal of Cancer · doi:10.1002/ijc.70188 · Cited by 2 · see citing works
Chen, C., Xiong, K., Liang, F., Zhong, Y., Qin, X., Huang, N., Fang, Y., Zhu, B., Cheng, J., Wei, Q., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-025-02553-x · Cited by 2 · see citing works
Li, H., Liu, C., Zhang, B., Zhang, Y., & Liu, Y. (2026) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-026-06471-3 · Cited by 2 · see citing works
Wang, W., Zhou, W., Fan, J., Jiang, T., Yang, G., Song, C., Xu, S., Luo, H., & Liu, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1567527 · Cited by 1 · see citing works
Ruan, R., Dai, X., Zhang, L., Xiong, J., Yao, Y., & Deng, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152841 · Cited by 1 · see citing works
CXCL14 regulates ovarian endometriosis progression by targeting PCNA
Liu, M. (2025) · American Journal of Translational Research · doi:10.62347/vxnw1213
Strong Opponents: Overcoming Obstacles of Osteosarcoma Metastatic Adaptation in the Lungs
Yu, K. (2025) · American journal of student research. · doi:10.70251/hyjr2348.325964
Dai, Z., Sun, Y., Maihemuti, M., Du, J., & Jiang, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-10470-8
Single‐Cell RNA Sequencing Reveals the Critical Role of SEC16B in Lung Metastasis of Osteosarcoma
Liu, S., Tang, H., Li, S., Guan, J., Cai, Y., Li, H., Yan, W., Dai, W., Xiao, D., Zou, Z., et al. (2025) · FASEB BioAdvances · doi:10.1096/fba.2024-00161
Duan, L. L., Zhu, H., Chen, C., & Liu, W. (2026) · Holistic Integrative Oncology · doi:10.1007/s44178-026-00226-3
Li, H., Luo, J., Wang, Q., Zhang, Y., Li, Q., Wang, X., Liu, G., Shi, C., & Zhang, W. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103229
Self-citationMolecular characterization of cell dynamics during osteosarcoma progression
Li, X., Liu, J., Wang, Y., Hu, J., & Wang, Q. (2026) · Translational Oncology · doi:10.1016/j.tranon.2026.102899
The skeletal connectome: From molecular circuitry to systemic network medicine
Liu, W., Liu, D., Liu, Q., & Sun, Y. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100154
Comparative clinical and prognostic significance of integrin αvβ3, αvβ5, and αvβ6 in osteosarcoma
You, C., Zeng, F., Zhang, S., Xu, J., Ren, T., Xie, L., Song, Y., Tang, X., & Wei, R. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1888679
Self-citationThe bone vicious cycle: How the microenvironment drives osteosarcoma progression
Yang, L., Meng, S., Zhang, H., Kang, X., Sun, N., Li, J., Zhao, L., Wang, Z., Ren, Z., Li, L., et al. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.115147
Shi, J., & Chen, R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1919497
Dai, Y., & Ding, W. (2026) · Molecular Diversity · doi:10.1007/s11030-026-11707-y
Yin, J., Lu, S., Liu, Y., Gong, M., Zha, Y., & Jiang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1928701
Self-citationSpatial ligand–receptor circuits in osteosarcoma: immune resistance in bone and lung niches
Qiu, Y., Deng, S., Junfeng, Z., Tan, Q., Pan, Y., Li, E., Ren, K., & Wu, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1932933
Gu, Y., 庄云强, & Zhang, W. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1987843
Tang, Q., Cheng, J., Lu, Y., 黄俊辉, & Bin, X. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179468
Self-citation
- Authors
- Xu, Y., Deng, C., Chen, H., Song, Y., Xu, H., Song, G., Wang, X., Luo, T., Chen, W., Ma, J., Zeng, A., Huang, S., Chen, Z., Fu, J., Gong, M., Tai, Y., Huang, A., Feng, H., Hu, J., Zhu, X., Tang, Q., Lu, J., & Wang, J.
- Affiliations
- Sun Yat-sen University (CN)
- Nanfang Hospital (CN)
- Guangzhou First People's Hospital (CN)
- Corresponding author
- Tang, Qinglian
- Lu, Jinchang
- Wang, Jin
- ORCID
- Venue
- Cancer Research
- Published
- 2024-01-31
- Volume
- 84
- Issue
- 7
- Pages
- 994-1012
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W4391380634
- Cited by
- 41
- References
- 58
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 6
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (91959115, 81872183, 81872268, 82073034, 82103669)
- Natural Science Foundation of Guangdong Province (2020A1515110210)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Keywords
- osteosarcoma, lung metastasis, CXCL14, integrin α11β1, tumor microenvironment, cancer-associated fibroblasts, stromal reprogramming, cancer stem cells, TGF-beta, actomyosin contractility, extracellular matrix remodeling, metastatic niche, single-cell RNA sequencing
- MeSH terms
- Fibroblasts, Humans, Lung, Lung Neoplasms, Osteosarcoma, Integrins, Transforming Growth Factor beta, Chemokines, CXC, Receptors, Collagen, Cell Line, Tumor, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
