Methylated DNA collected by tampons: a new tool to detect endometrial cancer.
Open accessAbstract
This proof of principle study aimed to define a new and simple strategy for detection of endometrial cancer using epigenetic markers. We investigated DNA isolated from vaginal secretion collected from tampon for aberrant methylation of five genes (CDH13, HSPA2, MLH1, RASSF1A, and SOCS2) using MethyLight in 15 patients with endometrial cancer and 109 patients without endometrial cancer. All endometrial cancer patients revealed three or more methylated genes, whereas 91% (99 of 109) of the patients without endometrial cancer had no or fewer than three genes methylated in their vaginal secretion. The methods developed in this study provide the basis for a prospective clinical trial to screen asymptomatic women who are at high risk for endometrial cancer.
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- Authors
- Fiegl, H., Gattringer, C., Widschwendter, A., Schneitter, A., Ramoni, A., Sarlay, D., Gaugg, I., Goebel, G., Müller, H. M., Mueller-Holzner, E., Marth, C., & Widschwendter, M.
- Affiliations
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- 1Department of Obstetrics and Gynecology, Innsbruck University Hospital and
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2004-05-01
- Volume
- 13
- Issue
- 5
- Pages
- 882-888
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- OpenAlex
- W2138417195
- Cited by
- 123
- References
- 18
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometrial cancer, DNA methylation, vaginal secretions, tampons, epigenetic biomarkers, cancer screening, CDH13, HSPA2, MLH1, RASSF1A, SOCS2, MethyLight
- MeSH terms
- Base Sequence, DNA, Neoplasm, Female, Humans, Molecular Sequence Data, Neoplasm Proteins, Probability, Sampling Studies, Sensitivity and Specificity, Tampons, Surgical, Biomarkers, Tumor, Vaginal Smears, Case-Control Studies, Polymerase Chain Reaction, Genes, Tumor Suppressor, Endometrial Neoplasms, Statistics, Nonparametric, DNA Methylation
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