Cited by 123Epigenetics and DNA MethylationCervical Cancer and HPV ResearchEndometrial and Cervical Cancer Treatments

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Methylated DNA collected by tampons: a new tool to detect endometrial cancer.

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Fiegl, Heidi, Gattringer, Conny, Widschwendter, Andreas, Schneitter, Alois, Ramoni, Angela, Sarlay, Daniela, Gaugg, Inge, Goebel, Georg, Müller, Hannes M., Mueller-Holzner, Elisabeth, Marth, Christian, Widschwendter, Martin·2004·Cancer Epidemiology, Biomarkers & Prevention

DOI 10.1158/1055-9965.882.13.5

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Abstract

This proof of principle study aimed to define a new and simple strategy for detection of endometrial cancer using epigenetic markers. We investigated DNA isolated from vaginal secretion collected from tampon for aberrant methylation of five genes (CDH13, HSPA2, MLH1, RASSF1A, and SOCS2) using MethyLight in 15 patients with endometrial cancer and 109 patients without endometrial cancer. All endometrial cancer patients revealed three or more methylated genes, whereas 91% (99 of 109) of the patients without endometrial cancer had no or fewer than three genes methylated in their vaginal secretion. The methods developed in this study provide the basis for a prospective clinical trial to screen asymptomatic women who are at high risk for endometrial cancer.

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Authors: Fiegl, H., Gattringer, C., Widschwendter, A., Schneitter, A., Ramoni, A., Sarlay, D., Gaugg, I., Goebel, G., Müller, H. M., Mueller-Holzner, E., Marth, C., & Widschwendter, M.
Affiliations: Innsbruck Medical University (AT)
Universität Innsbruck (AT)
1Department of Obstetrics and Gynecology, Innsbruck University Hospital and
ORCID: Fiegl, Heidi
Müller, Hannes M.
Marth, Christian
Widschwendter, Martin
Venue: Cancer Epidemiology, Biomarkers & Prevention
Publisher: American Association for Cancer Research (AACR)
Published: 2004-05-01
Volume: 13
Issue: 5
Pages: 882-888
ISSN: 1055-9965 (ISSN-L)
1538-7755
DOI: 10.1158/1055-9965.882.13.5
OpenAlex: W2138417195
Cited by: 123
References: 18
Citations by year: 2026: 5 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
FWCI: 2.25
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords: endometrial cancer, DNA methylation, vaginal secretions, tampons, epigenetic biomarkers, cancer screening, CDH13, HSPA2, MLH1, RASSF1A, SOCS2, MethyLight
MeSH terms: Base Sequence, DNA, Neoplasm, Female, Humans, Molecular Sequence Data, Neoplasm Proteins, Probability, Sampling Studies, Sensitivity and Specificity, Tampons, Surgical, Biomarkers, Tumor, Vaginal Smears, Case-Control Studies, Polymerase Chain Reaction, Genes, Tumor Suppressor, Endometrial Neoplasms, Statistics, Nonparametric, DNA Methylation

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Methylated DNA collected by tampons: a new tool to detect endometrial cancer.

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