The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Methylated DNA collected by tampons: a new tool to detect endometrial cancer.
Open accessAbstract
This proof of principle study aimed to define a new and simple strategy for detection of endometrial cancer using epigenetic markers. We investigated DNA isolated from vaginal secretion collected from tampon for aberrant methylation of five genes (CDH13, HSPA2, MLH1, RASSF1A, and SOCS2) using MethyLight in 15 patients with endometrial cancer and 109 patients without endometrial cancer. All endometrial cancer patients revealed three or more methylated genes, whereas 91% (99 of 109) of the patients without endometrial cancer had no or fewer than three genes methylated in their vaginal secretion. The methods developed in this study provide the basis for a prospective clinical trial to screen asymptomatic women who are at high risk for endometrial cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cancer-epigenetics comes of age
Jones, P. A., & Laird, P. W. (1999) · Nature Genetics · doi:10.1038/5947 · Cited by 2,358
MethyLight: a high-throughput assay to measure DNA methylation
Eads, C. A. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.8.e32 · Cited by 1,412
Smith, R. A., von Eschenbach, A. C., Wender, R. C., Levin, B., Byers, T., Rothenberger, D. A., Brooks, D. D., Creasman, W. T., Cohen, C. J., Runowicz, C. D., et al. (2001) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.51.1.38 · Cited by 815
Vasen, H. F. A., Wijnen, J., Menko, F. H., KLEIBEUKER, J. H., Taal, B. G., Griffioen, G. G., Nagengast, F. M., Meijers-Heijboer, E. H., Bertario, L., Varesco, L., et al. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8612988 · Cited by 812
Epigenetic patterns in the progression of esophageal adenocarcinoma.
Eads, C. A., Lord, R. V., Wickramasinghe, K. S., Long, T. I., Kurumboor, S. K., Bernstein, L., Peters, J. H., DeMeester, S. R., DeMeester, T. R., Skinner, K. A., et al. (2001) · PubMed · Cited by 500
Esteller, M., Levine, R. L., Baylin, S. B., Ellenson, L. H., & Herman, J. G. (1998) · Oncogene · doi:10.1038/sj.onc.1202178 · Cited by 493
DNA methylation errors and cancer.
Jones, P. A. (1996) · PubMed · Cited by 399
CpG island methylator phenotypes in aging and cancer
Toyota, M., & Issa, J. J. (1999) · Seminars in Cancer Biology · doi:10.1006/scbi.1999.0135 · Cited by 291
Langer, R. D., Pierce, J. J., O’Hanlan, K. A., Johnson, S. R., Espeland, M. A., Trabal, J. F., Barnabei, V. M., Merino, M. J., & Scully, R. E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712183372502 · Cited by 237
Sasaki, M., Dharia, A., Oh, B. R., Tanaka, Y., Fujimoto, S., & Dahiya, R. (2001) · PubMed · Cited by 148
Cited by
Sorted by citations
Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women
Clarke, M. A., Long, B. J., Del Mar Morillo, A., Arbyn, M., Bakkum-Gamez, J. N., & Wentzensen, N. (2018) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2018.2820 · Cited by 426
Clinical actionability of molecular targets in endometrial cancer
Urick, M. E., & Bell, D. W. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0177-x · Cited by 405
Role of the Ras-Association Domain Family 1 Tumor Suppressor Gene in Human Cancers
Agathanggelou, A., Cooper, W. N., & Latif, F. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4088 · Cited by 389
Guo, S.-W. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap064 · Cited by 328
The Ras-association domain family (RASSF) members and their role in human tumourigenesis
van der Weyden, L., & Adams, D. J. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.06.003 · Cited by 284
Metadata
- Authors
- Fiegl, H., Gattringer, C., Widschwendter, A., Schneitter, A., Ramoni, A., Sarlay, D., Gaugg, I., Goebel, G., Müller, H. M., Mueller-Holzner, E., Marth, C., & Widschwendter, M.
- Affiliations
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- 1Department of Obstetrics and Gynecology, Innsbruck University Hospital and
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2004-05-01
- Volume
- 13
- Issue
- 5
- Pages
- 882-888
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- OpenAlex
- W2138417195
- Cited by
- 123
- References
- 18
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometrial cancer, DNA methylation, vaginal secretions, tampons, epigenetic biomarkers, cancer screening, CDH13, HSPA2, MLH1, RASSF1A, SOCS2, MethyLight
- MeSH terms
- Base Sequence, DNA, Neoplasm, Female, Humans, Molecular Sequence Data, Neoplasm Proteins, Probability, Sampling Studies, Sensitivity and Specificity, Tampons, Surgical, Biomarkers, Tumor, Vaginal Smears, Case-Control Studies, Polymerase Chain Reaction, Genes, Tumor Suppressor, Endometrial Neoplasms, Statistics, Nonparametric, DNA Methylation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
