Cigarette smoking and survival after ovarian cancer diagnosis
Open accessAbstract
We have examined the association between cigarette smoking and ovarian cancer survival in 676 women with invasive epithelial ovarian cancer, recruited into a case-control study in the early 1990s. Information about cigarette smoking and other personal and reproductive factors was obtained from a personal interview at the time of diagnosis. Cox proportional hazards models were used to evaluate the association between cigarette smoking and time to ovarian cancer death. Current smokers at diagnosis were more likely to die early than women who had never smoked [adjusted hazard ratio (HR), 1.36; 95% confidence interval (95% CI), 1.01-1.84]. Increased risks of dying were greater among those who had accumulated more pack-years of smoking (HR for 30+ pack-years compared with never smokers, 1.94; 95% CI, 1.41-2.66) and smoked more cigarettes per day (HR, 1.93; 95% CI, 1.37-2.73). All these associations were stronger among women with late-stage disease (HR for current versus never smokers, 1.58; 95% CI, 1.15-2.18). Time since quitting had little effect on survival after adjusting for lifetime smoking exposure. These results validate and extend recent findings and suggest that premorbid cigarette smoking is related to worse outcome in ovarian cancer patients. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2557–60)
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Post-diagnosis smoking is associated with increased all-cause and cancer-related mortality.
“and all-cause and cancer-related mortality.12,13”
From Efficacy of smartphone applications to help cancer patients quit smoking: Protocol of the Quit2Heal randomized controlled trial (2023) · cites this paper as [12]
The Results (p. 2) associate smoking at diagnosis with worse ovarian-cancer survival. But the paper explicitly limits its analysis to ovarian-cancer mortality, censoring deaths from other causes (Results, p. 2), and says it had no information on smoking after diagnosis (Discussion, p. 2). It therefore does not establish the claimed association for post-diagnosis smoking or all-cause mortality. (LLM, conf=0.90)
Experimental — accuracy not yet measuredQuitting smoking after a cancer diagnosis reduces harms and improves prognosis and survival odds.
“By contrast, quitting smoking after a cancer diagnosis dramatically reduces these harms and improves prognosis and odds of survival.6,12,13”
From Efficacy of smartphone applications to help cancer patients quit smoking: Protocol of the Quit2Heal randomized controlled trial (2023) · cites this paper as [12]
The Results (p. 2) associate smoking at diagnosis with worse survival in women with ovarian cancer and note better survival among former smokers. But smoking status was measured before diagnosis, not as quitting afterward; the apparent benefit of longer time since quitting was attenuated after adjustment for lifetime smoking exposure (Results, p. 2). The paper therefore does not establish that quitting after diagnosis dramatically improves prognosis or survival. (LLM, conf=0.87)
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Cites
p53 Protein Accumulation and Gene Mutation in the Progression of Human Prostate Carcinoma
Navone, N. M., Troncoso, P., Pisters, L. L., Goodrow, T. L., Palmer, J. L., Nichols, W. W., von Eschenbach, A. C., & Conti, C. J. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.20.1657 · Cited by 477 · see citing works
Cigarette Smoking Is Associated with Unhealthy Patterns of Nutrient Intake: a Meta-analysis
Dallongeville, J., Marécaux, N., Fruchart, J., & Amouyel, P. (1998) · Journal of Nutrition · doi:10.1093/jn/128.9.1450 · Cited by 469 · see citing works
Never-Smokers With Lung Cancer: Epidemiologic Evidence of a Distinct Disease Entity
Toh, C., Gao, F., Lim, W., Leong, S., Fong, K.-W., Yap, S., Hsu, A. A. L., Eng, P., Koong, H., Agasthian, T., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.8033 · Cited by 379 · see citing works
Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 Accumulation
Visakorpi, T., Kallioniemi, O., Heikkinen, A., et al. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.11.883 · Cited by 312 · see citing works
Purdie, D. M., Green, A. C., Bain, C. J., Siskind, V., Ward, B. G., Hacker, N. F., Quinn, M. A., Wright, R. G., Russell, P., & Susil, B. J. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910620606 · Cited by 237 · see citing works
Self-citationImproved Survival in Never-Smokers vs Current Smokers With Primary Adenocarcinoma of the Lung
Nordquist, L. T., Simon, G. R., Cantor, A. B., Alberts, W. M., & Bepler, G. (2004) · CHEST Journal · doi:10.1378/chest.126.2.347 · Cited by 228 · see citing works
Smoking and risk of total and fatal prostate cancer in United States health professionals.
Giovannucci, E. L., Rimm, E. B., Ascherio, A., Colditz, G. A., Spiegelman, D. L., Stampfer, M. J., & Willett, W. C. (1999) · PubMed · Cited by 157 · see citing works
Smoking history and cancer patient survival: a hospital cancer registry study.
Yu, G. P., Ostroff, J. S., Zhang, Z., Tang, J., & Schantz, S. P. (1997) · PubMed · Cited by 120 · see citing works
Dietary influences on survival after ovarian cancer
Nagle, C. M., Purdie, D. M., Webb, P. M., Green, A. C., Harvey, P. W., & Bain, C. J. (2003) · International Journal of Cancer · doi:10.1002/ijc.11204 · Cited by 107 · see citing works
Self-citationCigarette smoking and epithelial ovarian cancer by histologic type
Marchbanks, P. A. (2000) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(99)00531-1 · Cited by 95 · see citing works
Dikshit, R. P., Boffetta, P., Bouchardy, C., Merletti, F., Crosignani, P., Cuchi, T., Ardanáz, E., & Brennan, P. (2005) · International Journal of Cancer · doi:10.1002/ijc.21244 · Cited by 86 · see citing works
A Worse Prognosis for Smokers with Prostate Cancer
Daniell, H. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)67253-7 · Cited by 75 · see citing works
Koh, W., Yuan, J., Sun, C., Lee, H.-P., & Yu, M. C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2473 · Cited by 70 · see citing works
Cigarette Smoking and the Risk of Mucinous and Nonmucinous Epithelial Ovarian Cancer
Modugno, F., Ness, R. B., & Cottreau, C. M. (2002) · Epidemiology · doi:10.1097/00001648-200207000-00016 · Cited by 66 · see citing works
Survival of Women with Breast Cancer in Relation to Smoking
Manjer, J. (2000) · The European Journal of Surgery · doi:10.1080/110241500447227 · Cited by 62 · see citing works
Cigarette smoking and risk of epithelial ovarian cancer (Australia)
Green, A. C., Purdie, D., Bain, C. J., et al. (2001) · Cancer Causes & Control · doi:10.1023/a:1011297403819 · Cited by 58 · see citing works
Self-citationBody Mass Index in Relation to Ovarian Cancer Survival
Zhang, M., Xie, X., Lee, A. H., et al. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0519 · Cited by 58 · see citing works
Smoking and prognosis in women with breast cancer
Fentiman, I. S., Allen, D. S., & Hamed, H. (2005) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2005.00581.x · Cited by 56 · see citing works
Smoking and Overweight: Negative Prognostic Factors in Stage III Epithelial Ovarian Cancer
Kjærbye‐Thygesen, A., Frederiksen, K., Høgdall, E. V. S., Glud, E., Christensen, L. H., Høgdall, C. K., Blaakær, J., & Kjær, S. K. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0897 · Cited by 52 · see citing works
Cigarette Smoking and Increased Risk of Mucinous Epithelial Ovarian Cancer
Zhang, Y. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh015 · Cited by 51 · see citing works
Hussain, F., Aziz, H., Macchia, R. J., et al. (1992) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(92)91059-v · Cited by 29 · see citing works
Cigarette Smoking and Epithelial Ovarian Cancer by Histologic Type
Marchbanks, P. A., Wilson, H. G., Bastos, E., et al. (2000) · Obstetrics and Gynecology · doi:10.1097/00006250-200002000-00017 · Cited by 17 · see citing works
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- [8]8. fatal prostate cancer in United States health professionals. Cancer Epidemiol Biomarkers Prev 1999;8:277-82.
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Bricker, J. B., Watson, N. L., Heffner, J. L., Sullivan, B., Mull, K., Kwon, D., Westmaas, J. L., & Ostroff, J. (2020) · JMIR Formative Research · doi:10.2196/16652 · Cited by 41 · see citing works
Bricker, J. B., Westmaas, J. L., Ostroff, J. S., Mull, K. E., Sullivan, B. M., & Santiago-Torres, M. (2023) · Contemporary Clinical Trials · doi:10.1016/j.cct.2023.107180 · Cited by 2 · see citing works
- Authors
- Nagle, C. M., Bain, C. J., & Webb, P. M.
- Affiliations
- QIMR Berghofer Medical Research Institute (AU)
- The University of Queensland (AU)
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2006-12-01
- Volume
- 15
- Issue
- 12
- Pages
- 2557-2560
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- OpenAlex
- W2043733025
- Cited by
- 31
- References
- 22
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 6 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- cigarette smoking, ovarian cancer, survival, epithelial ovarian cancer, pack-years, smoking intensity, stage at diagnosis, smoking cessation, mortality risk
- MeSH terms
- Adult, Aged, Australia, Adenocarcinoma, Mucinous, Female, Humans, Middle Aged, Ovarian Neoplasms, Smoking, Time Factors, Survival Analysis
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