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Association of COMT Val108/158Met Genotype with Smoking Cessation in a Nicotine Replacement Therapy Randomized Trial
Open accessAbstract
We investigated the association of catechol O-methyltransferase (COMT) genotype with abstinence following a smoking cessation attempt among a large cohort of smokers who attempted to quit using either the nicotine transdermal patch or placebo and were followed up over an 8-year period following their initial cessation attempt. In addition, we examined the possible moderating influence of sex on any association. The genotype × treatment interaction effect at 12-week follow-up indicated a greater benefit of active nicotine replacement treatment compared with placebo on likelihood of abstinence in the COMT Met/Met genotype group (33% versus 12%), in comparison to the Met/Val + Val/Val group (22% versus 16%). Our results indicate that COMT genotype may moderate the effect of active transdermal nicotine patch compared with placebo, with reduced relative benefit of nicotine replacement therapy in individuals with Met/Val or Val/Val genotype. Our data follow an emerging pattern of results suggesting that genetic variation in the dopamine pathway may provide a future basis for tailored smoking cessation therapies, but indicate that different genes influencing various components of this pathway may have different effects on response to smoking cessation pharmacotherapy. (Cancer Epidemiol Biomarkers Prev 2007;16(6):1065–9)
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“Independent trials of NRT have found cessation rates to differ based on COMT genotype [85-87].”
From Relapse prevention for addictive behaviors (2011) · cites this paper as [86]
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Metadata
- Authors
- Johnstone, E. C., Elliot, K. M., David, S. P., Murphy, M. F. G., Walton, R. T., & Munafò, M. R.
- Affiliations
- 1Department of Clinical Pharmacology and
- Brown University (US)
- University of Oxford (GB)
- Medical Research Council (GB)
- 5Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2007-06-01
- Volume
- 16
- Issue
- 6
- Pages
- 1065-1069
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- PMC
- PMC2031911
- OpenAlex
- W2050054512
- Cited by
- 66
- References
- 43
- Citations by year
- 2024: 5 · 2023: 2 · 2022: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 3
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Explore Bristol Research (submittedVersion)
- Funders
- National Institute on Drug Abuse (K08DA014276)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- catechol-O-methyltransferase, COMT Val158Met polymorphism, smoking cessation, nicotine replacement therapy, nicotine patch, abstinence, genetic moderation, dopaminergic pathways, sex differences, pharmacogenetics
- MeSH terms
- Administration, Cutaneous, Adult, Catechol O-Methyltransferase, Double-Blind Method, Female, Genotype, Humans, Male, Nicotine, Polymorphism, Genetic, Sex Factors, Tobacco Use Disorder, Polymerase Chain Reaction, Smoking Cessation, Treatment Outcome, Nicotinic Agonists
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