Cited by 66Smoking Behavior and CessationPharmacogenetics and Drug MetabolismGenetic Associations and Epidemiology

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Association of COMT Val108/158Met Genotype with Smoking Cessation in a Nicotine Replacement Therapy Randomized Trial

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Johnstone, Elaine C., Elliot, Katherine M., David, Sean P., Murphy, Michael F.G., Walton, Robert T., Munafò, Marcus R.·2007·Cancer Epidemiology, Biomarkers & Prevention

DOI 10.1158/1055-9965.epi-06-0936PMC PMC2031911

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Abstract

We investigated the association of catechol O-methyltransferase (COMT) genotype with abstinence following a smoking cessation attempt among a large cohort of smokers who attempted to quit using either the nicotine transdermal patch or placebo and were followed up over an 8-year period following their initial cessation attempt. In addition, we examined the possible moderating influence of sex on any association. The genotype × treatment interaction effect at 12-week follow-up indicated a greater benefit of active nicotine replacement treatment compared with placebo on likelihood of abstinence in the COMT Met/Met genotype group (33% versus 12%), in comparison to the Met/Val + Val/Val group (22% versus 16%). Our results indicate that COMT genotype may moderate the effect of active transdermal nicotine patch compared with placebo, with reduced relative benefit of nicotine replacement therapy in individuals with Met/Val or Val/Val genotype. Our data follow an emerging pattern of results suggesting that genetic variation in the dopamine pathway may provide a future basis for tailored smoking cessation therapies, but indicate that different genes influencing various components of this pathway may have different effects on response to smoking cessation pharmacotherapy. (Cancer Epidemiol Biomarkers Prev 2007;16(6):1065–9)

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Authors: Johnstone, E. C., Elliot, K. M., David, S. P., Murphy, M. F. G., Walton, R. T., & Munafò, M. R.
Affiliations: 1Department of Clinical Pharmacology and
Brown University (US)
University of Oxford (GB)
Medical Research Council (GB)
5Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom
ORCID: Johnstone, Elaine C.
David, Sean P.
Murphy, Michael F.G.
Walton, Robert T.
Venue: Cancer Epidemiology, Biomarkers & Prevention
Publisher: American Association for Cancer Research (AACR)
Published: 2007-06-01
Volume: 16
Issue: 6
Pages: 1065-1069
ISSN: 1055-9965 (ISSN-L)
1538-7755
DOI: 10.1158/1055-9965.epi-06-0936
PMC: PMC2031911
OpenAlex: W2050054512
Cited by: 66
References: 43
Citations by year: 2024: 5 · 2023: 2 · 2022: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 3
FWCI: 5.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Explore Bristol Research (submittedVersion)
Funders: National Institute on Drug Abuse (K08DA014276)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: catechol-O-methyltransferase, COMT Val158Met polymorphism, smoking cessation, nicotine replacement therapy, nicotine patch, abstinence, genetic moderation, dopaminergic pathways, sex differences, pharmacogenetics
MeSH terms: Administration, Cutaneous, Adult, Catechol O-Methyltransferase, Double-Blind Method, Female, Genotype, Humans, Male, Nicotine, Polymorphism, Genetic, Sex Factors, Tobacco Use Disorder, Polymerase Chain Reaction, Smoking Cessation, Treatment Outcome, Nicotinic Agonists

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Association of COMT Val108/158Met Genotype with Smoking Cessation in a Nicotine Replacement Therapy Randomized Trial

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