CoChat
Sign Up
Cited by 72Clinical Laboratory Practices and Quality ControlInflammatory Biomarkers in Disease PrognosisBiomarkers in Disease Mechanisms

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Diurnal, Weekly, and Long-Time Variation in Serum Concentrations of YKL-40 in Healthy Subjects

Johansen, Julia S., Lottenburger, Tine, Nielsen, Hans Jørgen, Jensen, Jens Erik B., Svendsen, Mads N., Kollerup, Gine, Christensen, Ib J.·2008·Cancer Epidemiology, Biomarkers & Prevention
DOI 10.1158/1055-9965.epi-07-2766
Open this paper in CoChat — free account

Abstract

Abstract Serum YKL-40 is a potential biomarker of prognosis in cancer patients, but assessment of serum YKL-40 requires knowledge of its normal variation. In this study, we evaluated diurnal, weekly, and long-term variation in serum YKL-40 in healthy subjects using a commercial ELISA. The intra-assay coefficient of variation was ≤5.0% and interassay ≤10.2%. Systematic changes in diurnal measurements of serum YKL-40 could not be shown. Physical exercise for 20 min had no effect on serum YKL-40. The within-subject coefficient of variation, including variation over time and interassay, was 28.8% and 30.2% over a period of 2 and 3 years, and the intraclass correlation coefficients were 72.4% and 72.2%, indicating reasonable reliability of serum YKL-40 measurements. The 95% confidence limits for the difference between two measurements (same subject), including interassay variation, were a 52% reduction and a 109% increase in serum YKL-40. These studies show that relatively small variation is found in serum YKL-40 in healthy subjects. However, a single measurement of serum YKL-40 from an individual may not have a prognostic value, and serum YKL-40 alone cannot be a good biomarker for cancer because serum YKL-40 can be elevated in patients with other diseases characterized by inflammation and tissue remodeling. (Cancer Epidemiol Biomarkers Prev 2008;17(10):2603–8)

Overview

Integrity signals

Registry

Crossref · 10.1158/1055-9965.epi-07-2766

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Kirkwood TBL. Geometric means and measures of dispersion. Biometrics 1979;35:908–9.

Cited by

Sorted by citations

Related

Metadata

Authors
Johansen, J. S., Lottenburger, T., Nielsen, H. J., Jensen, J. E. B., Svendsen, M. N., Kollerup, G., & Christensen, I. J.
Affiliations
  • Herlev Hospital (DK)
  • University of Southern Denmark (DK)
  • 2Surgical Gastroenterology and
  • Hvidovre Hospital (DK)
  • University of Copenhagen (DK)
  • Rigshospitalet (DK)
ORCID
Venue
Cancer Epidemiology, Biomarkers & Prevention
Publisher
American Association for Cancer Research (AACR)
Published
2008-10-01
Volume
17
Issue
10
Pages
2603-2608
ISSN
  • 1055-9965 (ISSN-L)
  • 1538-7755
DOI
10.1158/1055-9965.epi-07-2766
OpenAlex
W2134360742
Cited by
72
References
34
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 4 · 2012: 1
FWCI
5.21
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • Herlev Hospital
  • Hvidovre Hospital
Topics
  • Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Keywords
YKL-40, serum biomarkers, diurnal variation, weekly variation, long-term variability, healthy volunteers, measurement reliability, physical activity, tumor markers, inflammation, tissue remodeling
MeSH terms
Chitinase-3-Like Protein 1, Adolescent, Adult, Aged, Circadian Rhythm, Enzyme-Linked Immunosorbent Assay, Female, Glycoproteins, Humans, Male, Middle Aged, Neoplasms, Prognosis, Reference Values, Biomarkers, Tumor, Reproducibility of Results, Exercise, Linear Models, Lectins, Adipokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review