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Effects of Supplemental Vitamin D and Calcium on Oxidative DNA Damage Marker in Normal Colorectal Mucosa: A Randomized Clinical Trial
Open accessAbstract
The exact antineoplastic effects of calcium and vitamin D3 in the human colon are unclear. Animal and in vitro studies show that these two agents reduce oxidative stress; however, these findings have never been investigated in humans. To address this, we conducted a pilot, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial to test the effects of calcium and vitamin D3 on a marker of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine (8-OH-dG), in the normal colorectal mucosa. Patients (N = 92) with at least one pathology-confirmed colorectal adenoma were treated with 2 g/d calcium and/or 800 IU/d vitamin D3 versus placebo over 6 months. Overall labeling and colorectal crypt distribution of 8-OH-dG in biopsies of normal-appearing rectal mucosa were detected by standardized automated immunohistochemistry and quantified by image analysis. After 6 months of treatment, 8-OH-dG labeling along the full lengths of colorectal crypts decreased by 22% (P = 0.15) and 25% (P = 0.10) in the calcium and vitamin D3 groups, respectively, but not in the calcium plus vitamin D3 group. The estimated treatment effects were strongest among participants with higher baseline colon crypt vitamin D receptor expression (P = 0.05). Overall, these preliminary results indicate that calcium and vitamin D3 may decrease oxidative DNA damage in the normal human colorectal mucosa, support the hypothesis that 8-OH-dG labeling in colorectal crypts is a treatable oxidative DNA damage biomarker of risk for colorectal neoplasms, and provide support for further investigation of calcium and vitamin D3 as chemopreventive agents against colorectal neoplasms. Cancer Epidemiol Biomarkers Prev; 19(1); 280–91
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“Treatment with vitamin D has been shown to decrease 8—hydroxy–2—deoxyguanosin, a marker of endogenous oxidative damage to DNA [150], increase Bax, a protein coding gene involved in apoptosis [150], regulates poly-ADP-ribose polymerase activity in the DNA damage response pathway [151], stabilize chromosomal structure and prevent double strand breaks [152].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [150]
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“Treatment with vitamin D has been shown to decrease 8—hydroxy–2—deoxyguanosin, a marker of endogenous oxidative damage to DNA [150], increase Bax, a protein coding gene involved in apoptosis [150], regulates poly-ADP-ribose polymerase activity in the DNA damage response pathway [151], stabilize chromosomal structure and prevent double strand breaks [152].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [150]
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Citations
Cites
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709
Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
Lappe, J. M., Travers‐Gustafson, D., Davies, K. M., Recker, R. R., & Heaney, R. P. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1586 · Cited by 1,445
Kasai, H. (1997) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(97)00035-5 · Cited by 1,157
THE USE OF A SELF-ADMINISTERED QUESTIONNAIRE TO ASSESS DIET FOUR YEARS IN THE PAST
Willett, W. C., SAMPSON, L., Browne, M. L., Stampfer, M. J., ROSNER, B. A., Hennekens, C. H., & Speizer, F. E. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114780 · Cited by 801
Colon Cancer: A Review of the Epidemiology
Potter, J. D., Slattery, M. L., Bostick, R. M., & Gapstur, S. M. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036132 · Cited by 767
Self-citationEstrogen plus Progestin and Colorectal Cancer in Postmenopausal Women
Chlebowski, R. T., Wactawski‐Wende, J., Ritenbaugh, C., Hubbell, F. A., Ascensão, J. L., Rodabough, R. J., Rosenberg, C. A., Taylor, V. M., Harris, R. E., Chen, C., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032071 · Cited by 663
Bile acids as carcinogens in human gastrointestinal cancers
Bernstein, H., Bernstein, C., Payne, C. M., Dvorakova, K., & Garewal, H. (2005) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.08.001 · Cited by 611
Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms
Lamprecht, S. A., & Lipkin, M. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1144 · Cited by 584
(1997) · PubMed · Cited by 581
Cited by
Sorted by citations
Items 101–149 of 149
Piotrowska, A., Wierzbicka, J., Kwiatkowska, K., Chodyński, M., Kutner, A., & Zmijewski, M. A. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173170 · Cited by 8
Yang, B., Gross, M. D., Fedirko, V., McCullough, M. L., & Bostick, R. M. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0168 · Cited by 7
Self-citationIrving, A. A., Duchow, E. G., Plum, L. A., & DeLuca, H. F. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.032300 · Cited by 8
Zhang, Y., Li, C.-N., Jiang, W., Wu, P., Liu, Y., Jin, X., Ren, H., Zhang, L., Mi, H., Zhou, X., et al. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.740988 · Cited by 7
Brandolino, S., Franzago, M., Murmura, G., Ricci, F., Gatta, V., Stuppia, L., & Vitacolonna, E. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00701-9 · Cited by 7
Isochromosome 12p Formation Regulates Vitamin D Metabolism in Testicular Cancer
Törzsök, P., Goubergen, J. V., Pichler, M., Pichler, R., & Santer, F. R. (2023) · Nutrients · doi:10.3390/nu15102384 · Cited by 7
Vitamin D and Oxidative Stress
Ting, H., & Lee, Y.-F. (2012) · Oxidative stress and disease · doi:10.1201/b13714-8 · Cited by 7
Kazemian, E., Akbari, M. E., Moradi, N., Gharibzadeh, S., Amouzegar, A., Jamshidi‐Naeini, Y., Mondul, A. M., Khademolmele, M., Ghodoosi, N., Zarins, K. R., et al. (2020) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000576 · Cited by 7
Kim, S., Park, E., & Park, J.-H. (2021) · Clinical Nutrition Research · doi:10.7762/cnr.2021.10.4.303 · Cited by 6
Vitamin D, oxidative stress, and diabetes: crossroads for new therapeutic approaches
Nikooyeh, B., Anari, R., & Neyestani, T. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815776-3.00039-5 · Cited by 6
Tu, H., Ahearn, T. U., Daniel, C. R., Gonzalez‐Feliciano, A. G., Seabrook, M. E., & Bostick, R. M. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22152 · Cited by 5
Self-citationda Costa, P. M., Martins, I., Neves, J., Cortez‐Pinto, H., & Velosa, J. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.06.959 · Cited by 5
Adverse effect propensity: A new feature of Gulf War illness predicted by environmental exposures
Golomb, B. A., & Han, J. (2023) · iScience · doi:10.1016/j.isci.2023.107363 · Cited by 5
Long, Q., Zhang, X., & Bostick, R. M. (2011) · Biometrical Journal · doi:10.1002/bimj.201000070 · Cited by 5
Self-citationBong, Y., Assefnia, S., Tuohy, T. M. F., Neklason, D. W., Burt, R. W., Ahn, J., de Mesquita, P. J. B., & Byers, S. W. (2016) · Oncotarget · doi:10.18632/oncotarget.12768 · Cited by 5
Vitamin D, Oxidative Stress and Diabetes
Neyestani, T. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-405885-9.00011-5 · Cited by 4
Huang, J., Sun, W., Seong, K. M., Mittapalli, O., Ojo, J. A., Coates, B. S., Paige, K. N., Clark, J. M., & Pittendrigh, B. R. (2020) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2020.104631 · Cited by 5
Overview of Vitamin D Actions in Cancer
van Driel, M., van Leeuwen, J. P. T. M., Múñoz, A., & Feldman, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809963-6.00094-8 · Cited by 4
Cusato, J., Manca, A., Palermiti, A., Mula, J., Costanzo, M., Antonucci, M., Chiara, F., Vivo, E. D. D., Maiese, D., Ferrara, S. M., et al. (2023) · Antioxidants · doi:10.3390/antiox12051133 · Cited by 3
Shen, H., Ahearn, T. U., & Bostick, R. M. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.22090 · Cited by 3
Self-citationTaghizadeh, M., Samimi, M., Kolahdooz, F., Tabassi, Z., Jamilian, M., & Asemi, Z. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.954241 · Cited by 3
RetractedMaffei, F., Angelini, S., Forti, G. C., & Hrelia, P. (2013) · Current Colorectal Cancer Reports · doi:10.1007/s11888-012-0156-z · Cited by 3
[Research advances in the role of vitamin D in autism spectrum disorders].
Shan, L., Hu, X., Wang, B., & Jia, F. (2016) · PubMed Central · doi:10.7499/j.issn.1008-8830.2016.02.016 · Cited by 3
Antioxidants: A therapy for cryptorchidism, true or false?
Akang, E. N., Oremosu, A. A., & Osumah, O. (2017) · Journal of Experimental and Clinical Anatomy · doi:10.4103/jeca.jeca_11_17 · Cited by 3
Szymczak-Pajor, I., Antanaviciute, E. M., Drzewoski, J., Majsterek, I., & Śliwińska, A. (2025) · Antioxidants · doi:10.3390/antiox14091101 · Cited by 2
Hodge, R., Mandle, H. B., Ray, S., Tandon, S., Peterson, M., Henry, A., Jahan, F. A., Bostick, R. M., Baron, J. A., Barry, E. L., et al. (2018) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-18-0123 · Cited by 2
Self-citationVitamin D as therapeutic agent acting against cancers caused by proteases
Al-Suhaimi, E. A., Al-Khater, K. M., Aljafary, M. A., Ravinayagam, V., Shehzad, A., Al-Dossary, H. A., Assuhaimi, R. A., Tarhini, M., & Elaı̈ssari, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818168-3.00015-2 · Cited by 2
Cardiac and Renal Protective Role of Erythropoietin in a Rat Model of Acute Myocardial Infarction
Diab, A., Abulfadle, K. A., Mohammed, N. A., & hashim, F. (2021) · Zagazig University Medical Journal · doi:10.21608/zumj.2021.55172.2066 · Cited by 2
Trout ova, an alternative source of anti-B.
REES, P., Cotton, R., Pd, H., & Anstee, D. J. (1976) · PubMed · Cited by 2
Papier, K., Bradbury, K. E., Balkwill, A., Barnes, I. M., Smith-Byrne, K., Gunter, M. J., Berndt, S. I., Marchand, L. L., Wu, A. H., Peters, U., et al. (2024) · medRxiv · doi:10.1101/2024.06.12.24308822 · Cited by 2
Witonsky, D., Laxman, B., Usman, H., Bielski, M. C., Lawrence, K. M., & Kupfer, S. S. (2026) · PLoS Genetics · doi:10.1371/journal.pgen.1011983 · Cited by 1
Overview of vitamin D actions in cancer
van Driel, M., Múñoz, A., & van Leeuwen, J. P. T. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91338-6.00034-3 · Cited by 1
Effect of Li-Dope on Morphological and Optical Properties of ZnO Nanostructures
Saáedi, A., Cheraghizade, M., Aghaji, A. G., & Saedi, A. (2013) · Cited by 1
Asemi, Z., Samimi, M., Tabassi, Z., Shakeri, H., & Esmaillzadeh, A. (2013)
Jia, F., Shan, L., Feng, J., Wang, B., Li, H., & Du, L. (2014)
Sun, J. (2012) · Oxidative stress and disease · doi:10.1201/b13714-16
贾, 飞. (2014) · International Journal of Psychiatry and Neurology · doi:10.12677/ijpn.2014.34004
Kim, J., Roberts, J. M., & Weigel, N. L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6828-8_15
Ahearn, T. U., McCullough, M. L., Flanders, W. D., Long, Q., Sidelnikov, E., Fedirko, V., Daniel, C. R., Rutherford, R. E., Shaukat, A., & Bostick, R. M. (2023) · doi:10.1158/0008-5472.c.6501606.v1
Self-citationAhearn, T. U., McCullough, M. L., Flanders, W. D., Long, Q., Sidelnikov, E., Fedirko, V., Daniel, C. R., Rutherford, R. E., Shaukat, A., & Bostick, R. M. (2023) · doi:10.1158/0008-5472.c.6501606
Self-citationAvidime, O., Avidime, S., Randawa, A. J., Kawu, M. U., Mohammed, A., & Oweh, O. T. (2023) · Nigerian Journal of Physiological Sciences · doi:10.54548/njps.v38i1.3
Calculated Nutritional Indices in Symptomatic Hospitalized Nigerian Covid-19 Patients
Akinwumi, J. A., Edem, V. F., & Arinola, O. G. (2023) · Nigerian Journal of Physiological Sciences · doi:10.54548/njps.v38i1.4
Başak, F., & Demir, M. T. (2024) · Medical Journal of Western Black Sea · doi:10.29058/mjwbs.1444988
Gromadzki, B., Wiciński, M., Siedlecki, Z., Rzepiński, Ł., & Fajkiel-Madajczyk, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167990
Oda, Y., Meyer, M. B., Yeh, I., Lin, Z., Wong, C. T., Oh, D. H., & Bikle, D. D. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.106993
Youkun, C., Lu, D., Sun, T., Wu, J., Hou, H., Tao, Q., & Liu, Q. X. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuag090
Saadh, M. J., Saeed, T. N., Alfarttoosi, K. H., Sanghvi, G. V., Roopashree, R., Thakur, V., Lakshmi, L., Taher, W. M., Alwan, M., Jawad, M. J., et al. (2026) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_73_25
Metadata
- Authors
- Fedirko, V., Bostick, R. M., Long, Q., Flanders, W. D., McCullough, M. L., Sidelnikov, E., Daniel, C. R., Rutherford, R. E., & Shaukat, A.
- Affiliations
- American Cancer Society (US)
- Corresponding author
- Bostick, Roberd M.
- ORCID
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2010-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 280-291
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- PMC
- PMC2805163
- OpenAlex
- W2112110686
- Cited by
- 150
- References
- 59
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 2 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 13 · 2017: 2 · 2016: 9 · 2015: 13 · 2014: 15 · 2013: 15 · 2012: 17
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Georgia Cancer Coalition
- Emory University
- National Institutes of Health
- National Cancer Institute (R03CA136113, R01CA104637)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- vitamin D3, calcium supplementation, oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, colorectal mucosa, vitamin D receptor, colorectal adenoma, colorectal cancer chemoprevention, oxidative stress, DNA damage biomarkers
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Adenoma, Adult, Aged, Calcium Carbonate, Calcium, Dietary, Cholecalciferol, Deoxyguanosine, DNA Damage, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Intestinal Mucosa, Intestinal Neoplasms, Male, Middle Aged, Pilot Projects, Precancerous Conditions, Biomarkers, Tumor, Oxidative Stress, Dietary Supplements
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