Cited by 150Vitamin D Research StudiesAntioxidant Activity and Oxidative StressNutritional Studies and Diet

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Effects of Supplemental Vitamin D and Calcium on Oxidative DNA Damage Marker in Normal Colorectal Mucosa: A Randomized Clinical Trial

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Fedirko, Veronika, Bostick, Roberd M., Long, Qi, Flanders, W. Dana, McCullough, Marjorie L., Sidelnikov, Eduard, Daniel, Carrie R., Rutherford, Robin E., Shaukat, Aasma·2010·Cancer Epidemiology, Biomarkers & Prevention

DOI 10.1158/1055-9965.epi-09-0448PMC PMC2805163

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Abstract

The exact antineoplastic effects of calcium and vitamin D3 in the human colon are unclear. Animal and in vitro studies show that these two agents reduce oxidative stress; however, these findings have never been investigated in humans. To address this, we conducted a pilot, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial to test the effects of calcium and vitamin D3 on a marker of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine (8-OH-dG), in the normal colorectal mucosa. Patients (N = 92) with at least one pathology-confirmed colorectal adenoma were treated with 2 g/d calcium and/or 800 IU/d vitamin D3 versus placebo over 6 months. Overall labeling and colorectal crypt distribution of 8-OH-dG in biopsies of normal-appearing rectal mucosa were detected by standardized automated immunohistochemistry and quantified by image analysis. After 6 months of treatment, 8-OH-dG labeling along the full lengths of colorectal crypts decreased by 22% (P = 0.15) and 25% (P = 0.10) in the calcium and vitamin D3 groups, respectively, but not in the calcium plus vitamin D3 group. The estimated treatment effects were strongest among participants with higher baseline colon crypt vitamin D receptor expression (P = 0.05). Overall, these preliminary results indicate that calcium and vitamin D3 may decrease oxidative DNA damage in the normal human colorectal mucosa, support the hypothesis that 8-OH-dG labeling in colorectal crypts is a treatable oxidative DNA damage biomarker of risk for colorectal neoplasms, and provide support for further investigation of calcium and vitamin D3 as chemopreventive agents against colorectal neoplasms. Cancer Epidemiol Biomarkers Prev; 19(1); 280–91

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Authors: Fedirko, V., Bostick, R. M., Long, Q., Flanders, W. D., McCullough, M. L., Sidelnikov, E., Daniel, C. R., Rutherford, R. E., & Shaukat, A.
Affiliations: American Cancer Society (US)
Corresponding author: Bostick, Roberd M.
ORCID: Fedirko, Veronika
Bostick, Roberd M.
Long, Qi
Flanders, W. Dana
McCullough, Marjorie L.
Sidelnikov, Eduard
Daniel, Carrie R.
Shaukat, Aasma
Venue: Cancer Epidemiology, Biomarkers & Prevention
Publisher: American Association for Cancer Research (AACR)
Published: 2010-01-01
Volume: 19
Issue: 1
Pages: 280-291
ISSN: 1055-9965 (ISSN-L)
1538-7755
DOI: 10.1158/1055-9965.epi-09-0448
PMC: PMC2805163
OpenAlex: W2112110686
Cited by: 150
References: 59
Citations by year: 2026: 4 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 2 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 13 · 2017: 2 · 2016: 9 · 2015: 13 · 2014: 15 · 2013: 15 · 2012: 17
FWCI: 10.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Georgia Cancer Coalition
Emory University
National Institutes of Health
National Cancer Institute (R03CA136113, R01CA104637)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: vitamin D3, calcium supplementation, oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, colorectal mucosa, vitamin D receptor, colorectal adenoma, colorectal cancer chemoprevention, oxidative stress, DNA damage biomarkers
MeSH terms: 8-Hydroxy-2'-Deoxyguanosine, Adenoma, Adult, Aged, Calcium Carbonate, Calcium, Dietary, Cholecalciferol, Deoxyguanosine, DNA Damage, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Intestinal Mucosa, Intestinal Neoplasms, Male, Middle Aged, Pilot Projects, Precancerous Conditions, Biomarkers, Tumor, Oxidative Stress, Dietary Supplements

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Effects of Supplemental Vitamin D and Calcium on Oxidative DNA Damage Marker in Normal Colorectal Mucosa: A Randomized Clinical Trial

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