Transforming Epidemiology for 21st Century Medicine and Public Health
Open accessAbstract
In 2012, the National Cancer Institute (NCI) engaged the scientific community to provide a vision for cancer epidemiology in the 21st century. Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agencies, professional societies, and the research community emerged from the collective intellectual discourse. The themes are (i) extending the reach of epidemiology beyond discovery and etiologic research to include multilevel analysis, intervention evaluation, implementation, and outcomes research; (ii) transforming the practice of epidemiology by moving toward more access and sharing of protocols, data, metadata, and specimens to foster collaboration, to ensure reproducibility and replication, and accelerate translation; (iii) expanding cohort studies to collect exposure, clinical, and other information across the life course and examining multiple health-related endpoints; (iv) developing and validating reliable methods and technologies to quantify exposures and outcomes on a massive scale, and to assess concomitantly the role of multiple factors in complex diseases; (v) integrating “big data” science into the practice of epidemiology; (vi) expanding knowledge integration to drive research, policy, and practice; (vii) transforming training of 21st century epidemiologists to address interdisciplinary and translational research; and (viii) optimizing the use of resources and infrastructure for epidemiologic studies. These recommendations can transform cancer epidemiology and the field of epidemiology, in general, by enhancing transparency, interdisciplinary collaboration, and strategic applications of new technologies. They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits. Cancer Epidemiol Biomarkers Prev; 22(4); 508–16. ©2013 AACR.
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ML has emerged as an important tool in epidemiology and public health.
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- Authors
- Khoury, M. J., Lam, T. K., Ioannidis, J. P. A., Hartge, P., Spitz, M. R., Buring, J. E., Chanock, S. J., Croyle, R. T., Goddard, K. A., Ginsburg, G. S., Herceg, Z., Hiatt, R. A., Hoover, R. N., Hunter, D. J., Kramer, B. S., Lauer, M. S., Meyerhardt, J. A., Olopade, O. I., Palmer, J. R., Sellers, T. A., Seminara, D., Ransohoff, D. F., Rebbeck, T. R., Tourassi, G., Winn, D. M., Zauber, A., & Schully, S. D.
- Affiliations
- Boston University (US)
- ORCID
- Khoury, Muin J.
- Lam, Tram Kim
- Ioannidis, John P.A.
- Buring, Julie E.
- Chanock, Stephen J.
- Croyle, Robert T.
- Goddard, Katrina A.
- Ginsburg, Geoffrey S.
- Herceg, Zdenko
- Hiatt, Robert A.
- Lauer, Michael S.
- Meyerhardt, Jeffrey A.
- Olopade, Olufunmilayo I.
- Palmer, Julie R.
- Sellers, Thomas A.
- Ransohoff, David F.
- Rebbeck, Timothy R.
- Tourassi, Georgia
- Winn, Deborah M.
- Zauber, Ann
- Schully, Sheri D.
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2013-04-01
- Volume
- 22
- Issue
- 4
- Pages
- 508-516
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- PMC
- PMC3625652
- OpenAlex
- W2169521690
- Cited by
- 119
- References
- 51
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 18 · 2015: 28 · 2014: 14 · 2013: 10
- FWCI
- 72.02
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (Z99 CA999999)
- National Heart, Lung, and Blood Institute (T35HL007473)
- National Cancer Institute (Y99 CA999999, R01CA170508, P30CA008748)
- National Institute on Minority Health and Health Disparities
- Topics
- Social Sciences › Sociology and Political Science › Historical and modern epidemiology studies
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- cancer epidemiology, multilevel analysis, intervention evaluation, outcomes research, data sharing, reproducibility, cohort studies, life course exposure, big data, knowledge integration, epidemiologist training, translational research, research infrastructure
- MeSH terms
- Humans, Medical Oncology, Neoplasms, Public Health, United States, Epidemiologic Studies, Guidelines as Topic, Biomedical Research, History, 21st Century, National Cancer Institute (U.S.)
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