Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2

Gennari, Roberto; Menard, Sylvie; Fagnoni, Francesco; Ponchio, Luisa; Scelsi, Mario; Tagliabue, Elda; Castiglioni, Fabio; Villani, Laura; Magalotti, Cesare; Gibelli, Nadia; Oliviero, Barbara; Ballardini, Bettina; Prada, Gianantonio Da; Zambelli, Alberto; Costa, Alberto

doi:10.1158/1078-0432.ccr-04-0225

Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2

Purpose: To elucidate the mechanism by which trastuzumab, a humanized monoclonal antibody against HER2 with proven survival benefit in women with HER2-positive metastatic breast cancer, mediates its antitumor activity. Experimental Design: A pilot study including 11 patients with HER2-positive tu…