Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

Ohigashi, Yuichiro; Sho, Masayuki; Yamada, Yukishige; Tsurui, Yoshikazu; Hamada, Kaoru; Ikeda, Naoya; Mizuno, Takashi; Yoriki, Ryo; Kashizuka, Hisanori; Yane, Katsunari; Tsushima, Fumihiko; Otsuki, Noriko; Yagita, Hideo; Azuma, Miyuki; Nakajima, Yoshiyuki

doi:10.1158/1078-0432.ccr-04-1469

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

Purpose: The negative regulatory programmed death-1/programmed death-1 ligand (PD-1/PD-L) pathway in T-cell activation has been suggested to play an important role in tumor evasion from host immunity. In this study, we investigated the expression of PD-L1 and PD-L2 in human esophageal cancer to d…