Human Leukocyte Antigen Class I, MHC Class I Chain-Related Molecule A, and CD8+/Regulatory T-Cell Ratio: Which Variable Determines Survival of Cervical Cancer Patients?

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

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Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

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Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Sato, E., Olson, S. H., Ahn, J., Bundy, B. N., Nishikawa, H., Qian, F., Jungbluth, A. A., Frosina, D., Gnjatic, S., Ambrosone, C. B., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509182102 · Cited by 2,445

The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

Bingle, L., Brown, N. J., & Lewis, C. E. (2002) · The Journal of Pathology · doi:10.1002/path.1027 · Cited by 2,022

Immunosuppressive Strategies that are Mediated by Tumor Cells

Rabinovich, G. A., Gabrilovich, D. I., & Sotomayor, E. M. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141609 · Cited by 1,747

Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells

Davé, S. S., Wright, G. W., Tan, B. K., Rosenwald, A., Gascoyne, R. D., Chan, W. C., Fisher, R. I., Braziel, R. M., Rimsza, L. M., Grogan, T. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041869 · Cited by 1,417

Chapter 2: The burden of HPV-related cancers

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Roles of the NKG2D immunoreceptor and its ligands

Raulet, D. H. (2003) · Nature reviews. Immunology · doi:10.1038/nri1199 · Cited by 1,351

The natural history of cervical HPV infection: unresolved issues

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Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma

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A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens

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B7-H4 overexpression impairs the immune response of T cells in human cervical carcinomas

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A novel ferroptosis-related gene signature for predicting outcomes in cervical cancer

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Direct identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens

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Clinical significance of regulatory T cells in patients with myelodysplastic syndrome

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The Prevalence Of Cervical Regulatory T Cells in HPV‐Related Cervical Intraepithelial Neoplasia (CIN) Correlates Inversely with Spontaneous Regression of CIN

Kojima, S., Kawana, K., Tomio, K., Yamashita, A., Taguchi, A., Miura, S., Adachi, K., Nagamatsu, T., Nagasaka, K., Matsumoto, Y., et al. (2012) · American Journal of Reproductive Immunology · doi:10.1111/aji.12030 · Cited by 35

Protective effects of ulinastatin on pancreatic and renal damage in rats following early scald injury

Gao, C., Huan, J., Li, W., & Tang, J. (2009) · Burns · doi:10.1016/j.burns.2008.10.006 · Cited by 35

Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma

Rotman, J., Heeren, A. M., Gassama, A. A., Lougheed, S. M., Pocorni, N., Stam, A. G. M., Bleeker, M. C. G., Zijlmans, H. J. M. A. A., Mom, C. H., Kenter, G. G., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3826 · Cited by 35

Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion

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Allelic diversity of MICA gene and MICA/HLA-B haplotypic variation in a population of the Murcia region in southeastern Spain

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Comprehensive immunotherapy combined with intratumoral injection of zoledronate-pulsed dendritic cells, intravenous adoptive activated T lymphocyte and gemcitabine in unresectable locally advanced pancreatic carcinoma: a phase I/II trial

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Chromosome 5q Loss in Colorectal Flat Adenomas

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MHC Intratumoral Heterogeneity May Predict Cancer Progression and Response to Immunotherapy

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The appearance of Tregs in cancer nest is a promising independent risk factor in colon cancer

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Treatment outcomes of patients with adenocarcinoma of the uterine cervix after definitive radiotherapy and the prognostic impact of tumor-infiltrating CD8+ lymphocytes in pre-treatment biopsy specimens: a multi-institutional retrospective study

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GalNAcα1‐3Gal, a new prognostic marker for cervical cancer

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Highly immunosuppressive HLADRhi regulatory T cells are associated with unfavorable outcomes in cervical squamous cell carcinoma

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Immunologic impact of chemoradiation in cervical cancer and how immune cell infiltration could lead toward personalized treatment

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Immune microenvironment of cervical cancer and the role of IL-2 in tumor promotion

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CXCL12 is associated with FoxP3+ tumor‑infiltrating lymphocytes and affects the survival of patients with oral squamous cell carcinoma

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Systemic immune response in squamous cell carcinoma of the head and neck: a comparative concordance index analysis

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Activation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer

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Mechanisms of T-cell inhibition: implications for cancer immunotherapy

Mittendorf, E. A., & Sharma, P. (2009) · Expert Review of Vaccines · doi:10.1586/erv.09.144 · Cited by 26

Regulatory T Cells in Gynecologic Cancer

Ou, Y. (2018) · MOJ Immunology · doi:10.15406/moji.2018.06.00189 · Cited by 25

Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma

de Jong, R. A., Toppen, N. L., ten Hoor, K. A., Boezen, H. M., Kema, I. P., Hollema, H., & Nijman, H. W. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.12.416 · Cited by 25

FOXP3+regulatory T cells as biomarkers in human malignancies

Bignone, P. A., & Banham, A. H. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712590802494022 · Cited by 25

MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma

Sahasrabudhe, N. M., van der Horst, J. C., Spaans, V. M., Kenter, G. G., de Kroon, C. D., Bosse, T., van Vliet, S. J., & Jordanova, E. S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00029 · Cited by 25

PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma

Saglam, O., Zhou, J., Wang, X., & Conejo-Garcia, J. R. (2019) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0000000000000623 · Cited by 25

Immunotherapeutic Approaches for the Treatment of HPV-Associated (Pre-)Cancer of the Cervix, Vulva and Penis

Rafael, T. S., Rotman, J., Brouwer, O. R., van der Poel, H. G., Mom, C. H., Kenter, G. G., de Gruijl, T. D., & Jordanova, E. S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11041101 · Cited by 27

CD14+macrophage-like cells as the linchpin of cervical cancer perpetrated immune suppression and early metastatic spread: A new therapeutic lead?

Heeren, A. M., Kenter, G. G., Jordanova, E. S., & de Gruijl, T. D. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1009296 · Cited by 24

Targeting immune microenvironment in cervical cancer: current research and advances

Zhang, Z., Liu, M., An, Y., Gao, C., Wang, T., Zhang, Z., Zhang, G., Li, S., Li, W., Li, M., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06896-3 · Cited by 23

Immunogenetic biomarkers in inflammatory bowel diseases: Role of theIBD3region

Muro, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15037 · Cited by 23

Regulatory T Cells in Cancer

Curiel, T. J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9914-6_9 · Cited by 24

Expression of PD-L1 in cervical carcinoma and its impact on survival associated with T-cell infiltration and FoxP3 expression

Grochot, R. M., Brollo, J., Neto, F. R., Tregnago, A. C., Scholze, C., Norris, R., Silva, S., Weschenfelder, D. C., Reiriz, A. B., Michelin, L., et al. (2019) · Cancer Management and Research · doi:10.2147/cmar.s194597 · Cited by 22

A Review of the Effects of Cervical Cancer Standard Treatment on Immune Parameters in Peripheral Blood, Tumor Draining Lymph Nodes, and Local Tumor Microenvironment

van Luijk, I. F., Smith, S. M., Ojeda, M. C. M., Oei, A. L., Kenter, G. G., & Jordanova, E. S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092277 · Cited by 22

Forced co-expression of IL-21 and IL-7 in whole-cell cancer vaccines promotes antitumor immunity

Gu, Y., Fan, C., Lu, R., Shao, B., Sang, Y., Huang, Q., Li, X., Meng, W., Mo, X., & Wei, Y.-Q. (2016) · Scientific Reports · doi:10.1038/srep32351 · Cited by 22

The Pathophysiological Impact of HLA Class Ia and HLA-G Expression and Regulatory T Cells in Malignant Melanoma: A Review

Johansen, L. L., Lock‐Andersen, J., & Hviid, T. V. F. (2016) · Journal of Immunology Research · doi:10.1155/2016/6829283 · Cited by 22

TNFR2-expressing CD4+Foxp3+ regulatory T cells in cancer immunology and immunotherapy

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Microenvironmental stresses induce HLA‐E/Qa‐1 surface expression and thereby reduce CD8+ T‐cell recognition of stressed cells

Sasaki, T., Kanaseki, T., Shionoya, Y., Tokita, S., Miyamoto, S., Saka, E., Kochin, V., Takasawa, A., Hirohashi, Y., Tamura, Y., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545835 · Cited by 21

Biomarkers and experimental models for cancer immunology investigation

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The tumor area occupied by Tbet+ cells in deeply invading cervical cancer predicts clinical outcome

Gorter, A., Prins, F. A., van Diepen, M., Punt, S., & van der Burg, S. H. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0664-0 · Cited by 21

High levels of soluble MICA are significantly related to increased disease‐free and disease‐specific survival in patients with cervical adenocarcinoma

Samuels, S., Ferns, D. M., Meijer, D., van Straalen, J. P., Buist, M. R., Zijlmans, H. J. M. A. A., Kenter, G. G., & Jordanova, E. S. (2015) · Tissue Antigens · doi:10.1111/tan.12562 · Cited by 20

Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6

Klepsch, V., Siegmund, K., & Baier, G. (2021) · Cancers · doi:10.3390/cancers13112600 · Cited by 21

Human Leukocyte Antigen-DR Expression is Significantly Related to an Increased Disease-Free and Disease-Specific Survival in Patients With Cervical Adenocarcinoma

Samuels, S., Spaans, V. M., Osse, M., Peters, L. A. W., Kenter, G. G., Fleuren, G. J., & Jordanova, E. S. (2016) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000783 · Cited by 20

A four immune-related long noncoding RNAs signature as predictors for cervical cancer

Xu, M., Zhang, R., & Qiu, J. (2021) · Human Cell · doi:10.1007/s13577-021-00654-5 · Cited by 19

A machine learning model for grade 4 lymphopenia prediction during pelvic radiotherapy in patients with cervical cancer

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Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival

Punt, S., Corver, W. E., van der Zeeuw, S. A. J., Kiełbasa, S. M., Osse, E. M., Buermans, H. P. J., de Kroon, C. D., Jordanova, E. S., & Gorter, A. (2015) · Oncotarget · doi:10.18632/oncotarget.4526 · Cited by 19

MHC class I-related chain A and B ligands are differentially expressed in human cervical cancer cell lines

del Toro‐Arreola, S., Arreygue-Garcia, N., Aguilar‐Lemarroy, A., Cid-Arregui, Á., Jiménez-Pérez, M. I., Haramati, J., Barros‐Núñez, P., Gonzalez-Ramella, O. R., Toro‐Arreola, A. D., Ortiz‐Lazareno, P. C., et al. (2011) · Cancer Cell International · doi:10.1186/1475-2867-11-15 · Cited by 19

Regulatory T cells in cancer: where are we now?

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Prognostic impact of peripheral blood neutrophil to lymphocyte ratio in advanced-stage pulmonary large cell neuroendocrine carcinoma and its association with the immune-related tumour microenvironment

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T-regulatory cells in tumour-specific vaccination strategies

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Gyneco-oncological genomics and emerging biomarkers for cancer treatment with immune-checkpoint inhibitors

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The efficacy of a third-generation oncolytic herpes simplex viral therapy for an HPV-related uterine cervical cancer model

Kagabu, M., Yoshino, N., Saito, T., Miura, Y., Takeshita, R., Murakami, K., Kawamura, H., Baba, T., & Sugiyama, T. (2020) · International Journal of Clinical Oncology · doi:10.1007/s10147-020-01823-6 · Cited by 17

Treatment failure in patients with HPV 16-induced vulvar intraepithelial neoplasia: understanding different clinical responses to immunotherapy

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Immune Environment and Immunotherapy in Endometrial Carcinoma and Cervical Tumors

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T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities

Guo, W.-X., Dai, L., & Qiu, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1612032 · Cited by 16

On the Prognostic Power of Tumor-Infiltrating Lymphocytes – A Critical Commentary

Elkoshi, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.892543 · Cited by 15

CAR-T Cells Targeting HLA-G as Potent Therapeutic Strategy for EGFR Mutated and Overexpressed Oral Cancer

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Protective effects of ulinastatin on pulmonary damage in rats following scald injury

Gao, C., Liu, Y., Ma, L., & Wang, S. (2012) · Burns · doi:10.1016/j.burns.2012.02.004 · Cited by 15

Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis

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Immunotherapy for gynecologic cancers

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Early onset of severe lymphopenia during definitive radiotherapy correlates with mean body dose and predicts poor survival in cervical cancer

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Systematic Construction and Validation of a Novel Ferroptosis-Related Gene Model for Predicting Prognosis in Cervical Cancer

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Vaccines as early therapeutic interventions for cancer therapy: neutralising the immunosuppressive tumour environment and increasing T cell avidity may lead to improved responses

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New approaches in vaccine-based immunotherapy for human papillomavirus-induced cancer

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Morphometric analysis of the balance between CXCR3+ T cells and FOXP3+ regulatory T cells in lymphocyte-rich and conventional gastric cancers

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HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

Cao, J., Brouwer, N. J., Jordanova, E. S., Marinkovic, M., van Duinen, S. G., de Waard, N. E., Ksander, B. R., Mulder, A., Claas, F. H. J., Heemskerk, M. H. M., et al. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-23209 · Cited by 12

Immune stromal features in cervical squamous cell carcinoma are prognostic factors for distant metastasis: A retrospective study

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Role of regulatory T cells in cancer

Mir, M. A., & Mir, A. Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-443-18696-7.00001-4 · Cited by 11

The prognostic value of Th17/Treg cell in cervical cancer: a systematic review and meta-analysis

Zhang, J., Zhan, J., Guan, Z., Lin, X., Tian, L., Li, M., Zhang, C., & Zhong, L. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1442103 · Cited by 11

Extracellular Vesicles in Reprogramming of the Ewing Sarcoma Tumor Microenvironment

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Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma

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Increased expression of IL-21 reduces tumor growth by modulating the status of tumor-infiltrated lymphocytes

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Decidual infiltration of FoxP3+ regulatory T�cells, CD3+ T�cells, CD56+ decidual natural killer cells and Ki-67 trophoblast cells in hydatidiform mole compared to normal and ectopic pregnancies

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An exploration of the natural and acquired immunological mechanisms to high-risk human papillomavirus infection and unmasking immune escape in cervical cancer: A concise synopsis

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