Analysis of Fcγ receptor IIIa and IIa polymorphisms: lack of correlation with outcome in trastuzumab-treated breast cancer patients
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Abstract
PURPOSE: The mechanisms by which trastuzumab imparts clinical benefit remain incompletely understood. Antibody-dependent cellular cytotoxicity via interactions with Fcγ receptors (FcγR) on leukocytes may contribute to its antitumor effects. Single-nucleotide polymorphisms (SNP) in FCGR3A and FCGR2A genes lead to amino acid substitutions at positions 158 and 131, respectively, and affect binding of antibodies to FcγR such that 158V/V and 131H/H bind with highest affinity. This study aimed to determine whether high-affinity SNPs are associated with disease-free survival (DFS) among patients with HER2-positive nonmetastatic breast cancer. EXPERIMENTAL DESIGN: Genomic DNA was isolated from 1,286 patients enrolled in a trial of adjuvant trastuzumab-based chemotherapy. Genotyping was conducted using Sanger sequencing and Sequenom mass spectrometry. RESULTS: Patient samples (N = 1,189) were successfully genotyped for FCGR3A and 1,218 for FCGR2A. Compared with the overall results of the BCIRG006 study, in the subset of patients genotyped in this analysis, a less robust improvement in DFS was observed for the trastuzumab arms than control arm (HR, 0.842; P = 0.1925). When stratified for prognostic features, the HR in favor of trastuzumab was consistent with that of the overall study (HR, 0.74; P = 0.036). No correlation between DFS and FCGR3A/2A genotypes was seen for trastuzumab-treated patients (158V/V vs. V/F vs. F/F, P = 0.98; 131H/H vs. H/R vs. R/R, P = 0.76; 158V/V and/or 131H/H vs. others, P = 0.67). CONCLUSION: This analysis evaluating the association between FCGR3A/2A genotypes and trastuzumab efficacy in HER2-positive breast cancer did not show a correlation between FCGR3A-V/F and FCGR2A-H/R SNPs and DFS in patients treated with trastuzumab.
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A large trial of trastuzumab-based adjuvant chemotherapy in patients with early HER2+ breast cancer did not show an association between FCGR3A and FCGR2A polymorphisms with patient outcome.
“We should note, however, that a large trial of trastuzumab-based adjuvant chemotherapy in patients with early HER2+ breast cancer did not show an association between FCGR3A and FCGR2A polymorphisms with patient outcome (Hurvitz et al., 2012)”
From ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics (2014) · cites this paper as Hurvitz et al., 2012
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Cites
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J., Fry, B., Maller, J., & Daly, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bth457 · Cited by 15,086 · see citing works
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760 · see citing works
Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Fleming, T., Eiermann, W., Wolter, J., Pegram, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103153441101 · Cited by 11,500 · see citing works
Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer
Romond, E. H., Perez, E. A., Bryant, J., Suman, V. J., Geyer, C. E., Davidson, N. E., Tan-Chiu, E., Martino, S., Paik, S., Kaufman, P. A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa052122 · Cited by 5,355 · see citing works
Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer
Piccart-Gebhart, M. J., Procter, M., Leyland-Jones, B., Goldhirsch, A., Untch, M., Smith, I., Gianni, L., Baselga, J., Bell, R., Jackisch, C., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa052306 · Cited by 5,084 · see citing works
Adjuvant Trastuzumab in HER2-Positive Breast Cancer
Slamon, D. J., EIERMANN, W., Robert, N. J., Pieńkowski, T., Martín, M., Press, M. F., Mackey, J. R., Glaspy, J. A., Chan, A., Pawlicki, M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa0910383 · Cited by 2,785 · see citing works
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
Clynes, R. A., Towers, T. L., Presta, L. G., & Ravetch, J. V. (2000) · Nature Medicine · doi:10.1038/74704 · Cited by 2,768 · see citing works
Trastuzumab — Mechanism of Action and Use in Clinical Practice
Hudis, C. A. (2007) · New England Journal of Medicine · doi:10.1056/nejmra043186 · Cited by 2,592 · see citing works
SNPStats: a web tool for the analysis of association studies
Solé, X., Guinó, E., Valls, J., Iniesta, R., & Moreno, V. R. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl268 · Cited by 2,011 · see citing works
Cartron, G., Dacheux, L., Salles, G., Solal‐Céligny, P., BARDOS, P., Colombat, P., & Watier, H. (2002) · Blood · doi:10.1182/blood.v99.3.754 · Cited by 1,902 · see citing works
Weng, W., & Levy, R. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.05.013 · Cited by 1,300 · see citing works
Musolino, A., Naldi, N., Bortesi, B., Pezzuolo, D., Capelletti, M., Missale, G., Laccabue, D., Zerbini, A., Camisa, R., Bisagni, G., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.8957 · Cited by 981 · see citing works
Junttila, T. T., Akita, R. W., Parsons, K. L., Fields, C. T., Phillips, G. D. L., Friedman, L. S., Sampath, D., & Sliwkowski, M. X. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.020 · Cited by 829 · see citing works
Koene, H. R., Kleijer, M., Algra, J., Roos, D., Borne, A. E. G. K. V. D., & de Haas, M. (1997) · Blood · doi:10.1182/blood.v90.3.1109 · Cited by 796 · see citing works
Reporting Recommendations for Tumor Marker Prognostic Studies
McShane, L. M., Altman, D. G., Sauerbrei, W., Taube, S. E., Gion, M., & Clark, G. M. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2004.01.0454 · Cited by 780 · see citing works
Wu, J., Edberg, J. C., Redecha, P. B., Bansal, V., Guyre, P. M., Coleman, K. D., Salmon, J. E., & Kimberly, R. P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119616 · Cited by 711 · see citing works
Herceptin acts as an anti-angiogenic cocktail
Izumi, Y., Xu, L., di Tomaso, E., Fukumura, D., & Jain, R. K. (2002) · Nature · doi:10.1038/416279b · Cited by 623 · see citing works
Ravetch, J. V., & PERUSSIA, B. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.2.481 · Cited by 577 · see citing works
Bibeau, F., Lopez-Crapez, E., Di Fiore, F., Thezenas, S., Ychou, M., Blanchard, F., Lamy, A., Penault-Llorca, F., Frébourg, T., Michel, P., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.0463 · Cited by 521 · see citing works
Zhang, W., Gordon, M. A., Schultheis, A. M., Yang, D., Nagashima, F., Azuma, M., Chang, H.-M., Borucka, E., Lurje, G., Sherrod, A. E., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.8021 · Cited by 482 · see citing works
Warmerdam, P. A. M., van de Winkel, J. G. J., Vlug, A., WESTERDAAL, N. A. C., & Capel, P. J. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.4.1338 · Cited by 463 · see citing works
Junttila, T. T., Parsons, K. L., Olsson, C., Lu, Y., Xin, Y., Theriault, J., Crocker, L., Pabonan, O., Baginski, T., Meng, G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3704 · Cited by 222 · see citing works
Tamura, K., Shimizu, C., Hojo, T., Akashi‐Tanaka, S., Kinoshita, T., Yonemori, K., Kouno, T., Katsumata, N., Ando, M., Aogi, K., et al. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq585 · Cited by 186 · see citing works
Klos, K. S., Zhou, X., Lee, S., Zhang, L., Yang, W., Nagata, Y., & Yu, D. (2003) · Cancer · doi:10.1002/cncr.11656 · Cited by 110 · see citing works
Carlotti, E., Palumbo, G. A., Oldani, E., Tibullo, D., Salmoiraghi, S., Rossi, A., Golay, J., Pulsoni, A., Foà, R., & Rambaldi, A. (2007) · Haematologica · doi:10.3324/haematol.11288 · Cited by 96 · see citing works
Alizadeh, B. Z., Valdigem, G., Coenen, M. J. H., Zhernakova, A., Franke, B., Monsuur, A. J., van Riel, P. L. C. M., Barrera, P., Radstake, T. R. D. J., Roep, B. O., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm194 · Cited by 51 · see citing works
Alizadeh, B. Z., Broen, J. C. A., Rueda‐Medina, B., Hesselstrand, R., Wuttge, D. M., Simeón‐Aznar, C. P., Ortego‐Centeno, N., González-Gay, M. Á., Pros, A., Herrick, A. L., et al. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.091259 · Cited by 11 · see citing works
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ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics
Arteaga, C. L., & Engelman, J. A. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.02.025 · Cited by 1,048 · see citing works
Antibody Therapeutics in Cancer
Sliwkowski, M. X., & Mellman, I. (2013) · Science · doi:10.1126/science.1241145 · Cited by 539 · see citing works
Mellor, J. D., Brown, M. P., Irving, H. R., Zalcberg, J. R., & Dobrovic, A. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-1 · Cited by 417 · see citing works
Rugo, H. S., Im, S., Cardoso, F., Cortés, J., Curigliano, G., Musolino, A., Pegram, M. D., Wright, G. S., Saura, C., Escrivá-de-Romaní, S., et al. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2020.7932 · Cited by 348 · see citing works
Natural and therapy-induced immunosurveillance in breast cancer
Kroemer, G., Senovilla, L., Galluzzi, L., André, F., & Zitvogel, L. (2015) · Nature Medicine · doi:10.1038/nm.3944 · Cited by 308 · see citing works
The immune system and response to HER2-targeted treatment in breast cancer
Bianchini, G., & Gianni, L. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70477-7 · Cited by 282 · see citing works
Seidel, U. J. E., Schlegel, P., & Lang, P. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00076 · Cited by 236 · see citing works
Therapeutic Antibodies: What Have We Learnt from Targeting CD20 and Where Are We Going?
Marshall, M. J. E., Stopforth, R. J., & Cragg, M. S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01245 · Cited by 182 · see citing works
Luque-Cabal, M., García‐Teijido, P., Fernández-Pérez, Y., Sánchez‐Lorenzo, L., & Vázquez, I. P. (2016) · Clinical Medicine Insights Oncology · doi:10.4137/cmo.s34537 · Cited by 182 · see citing works
Kodack, D. P., Chung, E., Yamashita, H., Incio, J., Duyverman, A. M. M. J., Song, Y., Farrar, C. T., Huang, Y., Ager, E., Kamoun, W., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216078109 · Cited by 153 · see citing works
Current approaches and future directions in the treatment of HER2-positive breast cancer
Hurvitz, S. A., Hu, Y., O’Brien, N. A., & Finn, R. S. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.04.008 · Cited by 151 · see citing works
The Evolving Landscape of HER2 Targeting in Breast Cancer
Moasser, M. M., & Krop, I. E. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.2286 · Cited by 135 · see citing works
Role of Fcγ receptors in HER2-targeted breast cancer therapy
Musolino, A., Gradishar, W. J., Rugo, H. S., Nordstrom, J. L., Rock, E. P., Arnaldez, F. I., & Pegram, M. D. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003171 · Cited by 138 · see citing works
HER2-positive breast cancer: Current and new therapeutic strategies
Escrivá-de-Romaní, S., Arumí, M., Bellet, M., & Saura, C. (2018) · The Breast · doi:10.1016/j.breast.2018.03.006 · Cited by 132 · see citing works
Zahavi, D. J., Aldeghaither, D. S., O’Connell, A., & Weiner, L. M. (2018) · Antibody Therapeutics · doi:10.1093/abt/tby002 · Cited by 128 · see citing works
Griguolo, G., Pascual, T., Dieci, M. V., Guarneri, V., & Prat, A. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0548-6 · Cited by 118 · see citing works
Tsao, L.-C., Crosby, E. J., Trotter, T. N., Agarwal, P., Hwang, B.-J., Acharya, C. R., Shuptrine, C. W., Wang, T., Wei, J.-P., Yang, X. Y., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131882 · Cited by 117 · see citing works
Gavin, P. G., Song, N., Kim, S. R., Lipchik, C., Johnson, N. L., Bandos, H., Finnigan, M., Rastogi, P., Fehrenbacher, L., Mamounas, E. P., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.4884 · Cited by 113 · see citing works
Fcγ receptors: genetic variation, function, and disease
Hargreaves, C. E., Rose-Zerilli, M. J. J., Machado, L. R., Iriyama, C., Hollox, E. J., Cragg, M. S., & Strefford, J. C. (2015) · Immunological Reviews · doi:10.1111/imr.12341 · Cited by 102 · see citing works
Nagelkerke, S. Q., Schmidt, D. E., de Haas, M., & Kuijpers, T. W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02237 · Cited by 94 · see citing works
Perspectives of HER2-targeting in gastric and esophageal cancer
Gerson, J. N., Skariah, S., Denlinger, C. S., & Astsaturov, I. A. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1315406 · Cited by 93 · see citing works
Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study
Zhang, N., Liu, L., Dumitru, C. D., Houston-Cummings, N. R., Cukan, M. C., Jiang, Y., Li, Y., Li, F., Mitchell, T., Mallem, M. R., et al. (2011) · mAbs · doi:10.4161/mabs.3.3.15532 · Cited by 93 · see citing works
Muntasell, A., Cabo, M., Servitja, S., Tusquets, I., Martinez‐García, M., Rovira, A., Rojo, F., Albanell, J., & López‐Botet, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01544 · Cited by 90 · see citing works
Fifty years of monoclonals: the past, present and future of antibody therapeutics
Chan, A. C., Martyn, G. D., & Carter, P. J. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01207-9 · Cited by 96 · see citing works
Rugo, H. S., Im, S., Cardoso, F., Cortés, J., Curigliano, G., Musolino, A., Pegram, M. D., Bachelot, T., Wright, G. S., Saura, C., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.02937 · Cited by 87 · see citing works
Genotypes Affecting the Pharmacokinetics of Anticancer Drugs
den Besten-Bertholee, D., Maring, J. G., & Kuilenburg, A. B. P. (2016) · Clinical Pharmacokinetics · doi:10.1007/s40262-016-0450-z · Cited by 79 · see citing works
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Mandó, P., Rivero, S. G., Rizzo, M., Pinkasz, M., & Levy, E. M. (2021) · The Breast · doi:10.1016/j.breast.2021.08.007 · Cited by 76 · see citing works
HER2-positive breast cancer is lost in translation: time for patient-centered research
Gingras, I., Gebhart, G., de Azambuja, E., & Piccart, M. J. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.96 · Cited by 74 · see citing works
Vivekanandhan, S., & Knutson, K. L. (2022) · Cancers · doi:10.3390/cancers14205115 · Cited by 76 · see citing works
Anti-GD2 MABS and Next-Generation mAb-Based Agents for Cancer Therapy
Horta, Z. P., Goldberg, J. L., & Sondel, P. M. (2016) · Immunotherapy · doi:10.2217/imt-2016-0021 · Cited by 74 · see citing works
Liu, S. D., Chalouni, C. M., Young, J. C., Junttila, T. T., Sliwkowski, M. X., & Lowe, J. B. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0125 · Cited by 72 · see citing works
Roca, L., Dieras, V. C., Roche, H. H., Lappartient, E., Kerbrat, P., Cany, L., Chièze, S., Canon, J.-L. R., Spielmann, M., Penault-Llorca, F. M., et al. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2587-x · Cited by 70 · see citing works
Kurozumi, S., Inoue, K., Takei, H., Matsumoto, H., Kurosumi, M., Horiguchi, J., Takeyoshi, I., & Oyama, T. (2015) · BMC Cancer · doi:10.1186/s12885-015-1641-y · Cited by 68 · see citing works
Lesurf, R., Griffith, O. L., Griffith, M., Hundal, J., Trani, L., Watson, M. A., Aft, R., Ellis, M. J., Ota, D., Suman, V. J., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx048 · Cited by 68 · see citing works
Molecular determinants of trastuzumab efficacy: What is their clinical relevance?
De, P. K. R., Hasmann, M., & Leyland-Jones, B. R. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.02.006 · Cited by 66 · see citing works
Nagelkerke, S. Q., Tacke, C. E. A., Breunis, W. B., Tanck, M. W. T., Geissler, J., Png, E., Hoang, L. T., van der Heijden, J., Naim, A. N. M., Yeung, R. S. M., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00185 · Cited by 64 · see citing works
Fan, X., Brezski, R. J., Fa, M., Deng, H., Greenplate, A. R., Gonzalez, A. O., Dubinsky, W. P., Strohl, W. R., Jordan, R. E., Zhang, N., et al. (2012) · Breast Cancer Research · doi:10.1186/bcr3240 · Cited by 62 · see citing works
Clinicopathological values of PD-L1 expression in HER2-positive breast cancer
Kurozumi, S., Inoue, K., Matsumoto, H., Fujii, T., Horiguchi, J., Oyama, T., Kurosumi, M., & Shirabe, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-52944-6 · Cited by 51 · see citing works
Boero, S., Morabito, A., Banelli, B., Cardinali, B., Dozin, B., Lunardi, G., Piccioli, P., Lastraioli, S., Carosio, R., Salvi, S., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0680-0 · Cited by 49 · see citing works
Pharmacogenomics of breast cancer therapy: An update
Westbrook, K. E., & Stearns, V. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.03.001 · Cited by 49 · see citing works
Kurozumi, S., Padilla, M., Kurosumi, M., Matsumoto, H., Inoue, K., Horiguchi, J., Takeyoshi, I., Oyama, T., Ranger‐Moore, J., Allred, D. C., et al. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3856-2 · Cited by 49 · see citing works
Kurozumi, S., Inoue, K., Matsumoto, H., Fujii, T., Horiguchi, J., Oyama, T., Kurosumi, M., & Shirabe, K. (2019) · Scientific Reports · doi:10.1038/s41598-018-38272-1 · Cited by 49 · see citing works
Norton, N., Olson, R. M., Pegram, M. D., Tenner, K., Ballman, K. V., Clynes, R., Knutson, K. L., & Perez, E. A. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0059 · Cited by 48 · see citing works
Biological role of NK cells and immunotherapeutic approaches in breast cancer
Roberti, M. P., Mordoh, J., & Levy, E. M. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00375 · Cited by 47 · see citing works
The Neutrophil: The Underdog That Packs a Punch in the Fight against Cancer
Avtenyuk, N. U., Visser, N., Bremer, E., & Wiersma, V. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217820 · Cited by 45 · see citing works
Treffers, L. W., Zhao, X. W., van der Heijden, J., Nagelkerke, S. Q., van Rees, D. J., Gonzalez, P., Geissler, J., Verkuijlen, P., van Houdt, M., de Boer, M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201747215 · Cited by 42 · see citing works
Kurozumi, S., Fujii, T., Matsumoto, H., Inoue, K., Kurosumi, M., Horiguchi, J., & Kuwano, H. (2017) · Medical Molecular Morphology · doi:10.1007/s00795-017-0170-y · Cited by 42 · see citing works
Muntasell, A., Servitja, S., Cabo, M., Bermejo, B., Pérez‐Buira, S., Rojo, F., Costa-García, M., Arpí, O., Moraru, M., Serrano, L., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0896 · Cited by 40 · see citing works
Zhang, B., Shi, J., Shi, X., Xu, X., Gao, L., Liu, M., Liu, M., Gao, M., Jin, S., Zhou, J., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101068 · Cited by 38 · see citing works
Challenges and prospects in HER2-positive breast cancer-targeted therapy
Li, X., Zhang, X., Yin, S., & Nie, J. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104624 · Cited by 36 · see citing works
Batalha, S., Cristóvão‐Ferreira, S., & Brito, C. (2021) · Cancers · doi:10.3390/cancers13061305 · Cited by 30 · see citing works
Wege, A. K., Weber, F., Kroemer, A., Ortmann, O., Nimmerjahn, F., & Brockhoff, G. (2016) · Oncotarget · doi:10.18632/oncotarget.13159 · Cited by 30 · see citing works
Musolino, A., Naldi, N., Dieci, M. V., Zanoni, D., Rimanti, A., Boggiani, D., Sgargi, P., Generali, D., Piacentini, F., Ambroggi, M., et al. (2016) · The Pharmacogenomics Journal · doi:10.1038/tpj.2016.51 · Cited by 29 · see citing works
Geva, R., Vecchione, L., Kalogeras, K. T., Jensen, B. V., Lenz, H., Yoshino, T., Páez, D., Montagut, C. O., Souglakos, J., Cappuzzo, F., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-307234 · Cited by 28 · see citing works
Huang, L., Chen, S., Yang, W., Xu, B., Huang, T., Yang, H., Zheng, H. Y., Wang, Y., Song, E., Zhang, J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4337 · Cited by 23 · see citing works
Relevance of Fc Gamma Receptor Polymorphisms in Cancer Therapy With Monoclonal Antibodies
Mata, J. J., Rebollo-Liceaga, J., Martinez-Navarro, E., Manzano, R. G., Brugarolas, A., Juan, M., & Sureda, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.926289 · Cited by 23 · see citing works
Genetic Influences in Breast Cancer Drug Resistance
Daniyal, A., Santoso, I., Gunawan, N. H. P., Barliana, M. I., & Abdulah, R. (2021) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s284453 · Cited by 22 · see citing works
Musolino, A., Boggiani, D., Pellegrino, B., Zanoni, D., Sikokis, A., Missale, G., Silini, E. M., Maglietta, G., Frassoldati, A., & Michiara, M. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.102927 · Cited by 20 · see citing works
Antitumor Immunity: Easy as 1, 2, 3 with Monoclonal Bispecific Trifunctional Antibodies?
Maher, J. F., & Adami, A. A. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1852 · Cited by 20 · see citing works
Margetuximab in HER2-positive metastatic breast cancer
Gradishar, W. J., O'Regan, R. M., Rimawi, M. F., Nordstrom, J. L., Rosales, M. K., & Rugo, H. S. (2023) · Future Oncology · doi:10.2217/fon-2022-1040 · Cited by 21 · see citing works
Natural killer cell phenotype is altered in HIV-exposed seronegative women
Zhao, N. Q., Vendrame, E., Ferreira, A.-M., Seiler, C., Ranganath, T., Alary, M., Labbé, A., Guédou, F. A., Poudrier, J., Holmes, S., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238347 · Cited by 20 · see citing works
Antitumor Efficacy of Anti-GD2 IgG1 Is Enhanced by Fc Glyco-Engineering
Xu, H., Guo, H.-F., Cheung, I. Y., & Cheung, N. V. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0221 · Cited by 19 · see citing works
Wang, D., Wei, X., Wang, Z.-Q., Lu, Y., Shi, S.-M., Wang, N., Qiu, M., Wang, F.-H., Wang, R.-J., Li, Y., et al. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s142620 · Cited by 19 · see citing works
Hirvinen, M., Heiskanen, R., Oksanen, M., Pesonen, S. K., Liikanen, I., Joensuu, T. K., Kanerva, A., Cerullo, V., & Hemminki, A. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-193 · Cited by 19 · see citing works
Fiedler, W., Stoeger, H., Perotti, A., Gastl, G. A., Weidmann, J., Dietrich, B., Baumeister, H., Danielczyk, A., Goletz, S., Salzberg, M. O., et al. (2018) · ESMO Open · doi:10.1136/esmoopen-2018-000381 · Cited by 17 · see citing works
Shimizu, C., Mogushi, K., Morioka, M. S., Yamamoto, H., Tamura, K., Fujiwara, Y., & Tanaka, H. (2015) · Breast Cancer · doi:10.1007/s12282-015-0614-y · Cited by 17 · see citing works
Miolo, G., Muraro, E., Martorelli, D., Lombardi, D., Scalone, S., Spazzapan, S., Massarut, S., Perin, T., Viel, E., Comaro, E., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-954 · Cited by 16 · see citing works
Clinical Perspectives on Targeting Therapies for Personalized Medicine
Singer, D. R. J., & Zaïr, Z. M. (2015) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2015.11.003 · Cited by 15 · see citing works
Deligne, C., Milcent, B., Josseaume, N., Teillaud, J., & Sibéril, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00950 · Cited by 15 · see citing works
Pharmacokinetics, pharmacodynamics and clinical efficacy of pertuzumab in breast cancer therapy
Rocca, A., Andreis, D., Fedeli, A., Maltoni, R., Sarti, S., Cecconetto, L., Pietri, E., Schirone, A., Bravaccini, S., Serra, P., et al. (2015) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2015.1078311 · Cited by 16 · see citing works
Maskalenko, N. A., Zahroun, S., Tsygankova, O., Anikeeva, N., Sykulev, Y. K., & Campbell, K. S. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0384 · Cited by 13 · see citing works
Stein, M. M., Hrusch, C. L., Sperling, A. I., & Ober, C. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0038-8 · Cited by 13 · see citing works
De Novo Resistance Biomarkers to Anti-Her2 Therapies in Her2-Positive Breast Cancer
Madrid-Paredes, A., Cañadas‐Garre, M., Sánchez–Pozo, A., & Calleja‐Hernández, M. Á. (2015) · Pharmacogenomics · doi:10.2217/pgs.15.88 · Cited by 12 · see citing works
Husna, S. M. N., & Wong, K. K. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.10.005 · Cited by 11 · see citing works
The Role of Pharmacogenetic-Based Pharmacokinetic Analysis in Precise Breast Cancer Treatment
Wu, X., & Xiong, H. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16111407 · Cited by 10 · see citing works
Cocca, M., Bedognetti, D., Bianca, M. L., Gasparini, P., & Girotto, G. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0778-z · Cited by 10 · see citing works
Exploiting Antibody Biology for the Treatment of Cancer
Khanna, V., Panyam, J., & Griffith, T. S. (2020) · Immunotherapy · doi:10.2217/imt-2019-0118 · Cited by 9 · see citing works
Kløve‐Mogensen, K., Steffensen, R., Masmas, T. N., Glenthøj, A. B., Jensen, C. F., Haunstrup, T. M., Ratcliffe, P., Höglund, P., Hasle, H., & Nielsen, K. R. (2023) · International Journal of Immunogenetics · doi:10.1111/iji.12614 · Cited by 8 · see citing works
Kløve‐Mogensen, K., Terp, S. K., & Steffensen, R. (2024) · Journal of Immunological Methods · doi:10.1016/j.jim.2024.113628 · Cited by 8 · see citing works
Investigational drugs in early stage clinical trials for the treatment of HER2+ breast cancer
Gombos, A., Franzoi, M. A., & Awada, A. H. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1633306 · Cited by 8 · see citing works
Murphy, K. E., Niederer, H. A., King, K. S., Harris, E. C., Glass, S. M., & Cox, C. J. (2015) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000175 · Cited by 8 · see citing works
Serum immunoglobulin and the threshold of Fc receptor-mediated immune activation
Bauer-Smith, H., Sudol, A. S. L., Beers, S. A., & Crispin, M. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130448 · Cited by 9 · see citing works
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Hertz, D. L., & Rae, J. M. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22909-6_8 · Cited by 6 · see citing works
Predictive Value of FcR Polymorphisms
Dolcetti, R. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.4905 · Cited by 6 · see citing works
Furrer, D., Dragic, D., Chang, S.-L., Fournier, F., Droit, A., Jacob, S., & Diorio, C. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2022.63 · Cited by 6 · see citing works
Botticelli, A., Mazzuca, F., Borro, M., Mazzotti, E., Torre, M. L., Bonifacino, A., Ciabatta, F. R., Gentile, G., Maddalena, C., Simmaco, M., et al. (2015) · World Journal of Oncology · doi:10.14740/wjon934w · Cited by 4 · see citing works
Matlawska‐Wasowska, K., Gale, J. M., Nickl, C. K., Khalili, P., Shirley, B., Wilson, B. S., Vasef, M. A., & Winter, S. S. (2014) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-014-0120-5 · Cited by 4 · see citing works
Breast Cancer Pharmacogenetics in the Era of Personalized Medicine
Yao, S., Maghsoudlou, D., & Ambrosone, C. B. (2012) · Current Breast Cancer Reports · doi:10.1007/s12609-012-0088-2 · Cited by 4 · see citing works
FCGR3A V158F gene polymorphism and trastuzumab response in HER2-positive breast cancer patients
Abdel-Wahed, M. A., Sabbour, G. S., Hamed, A. I., Kady, M. S. E., Mohammed, S. K., & Shaaban, M. A. A. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-76024-6 · Cited by 3 · see citing works
Immunotherapy for HER2-Positive Breast Cancer: Changing the Paradigm
Soberino, J., Racca, F., Pérez-García, J. M., García‐Fernández, L., & Cortés, J. (2019) · Current Breast Cancer Reports · doi:10.1007/s12609-019-00332-4 · Cited by 3 · see citing works
Rožman, S., Novaković, S., Grabnar, I., Cerkovnik, P., & Novaković, B. J. (2016) · Oncology Letters · doi:10.3892/ol.2016.4402 · Cited by 2 · see citing works
Monoclonal Antibodies for Cancer Therapy and Prevention
Zhang, H., Samanta, A., Nagai, Y., Tsuchiya, H., Ohtani, T., Cai, Z., Zhu, Z., Liu, J., & Greene, M. I. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394296-8.00014-2 · Cited by 2 · see citing works
Update Breast Cancer 2022 Part 5 – Early Stage Breast Cancer
Fehm, T. N., Welslau, M., Müller, V., Lüftner, D., Schütz, F., Fasching, P. A., Janni, W., Thomssen, C., Witzel, I., Beierlein, M., et al. (2023) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-2018-9053 · Cited by 2 · see citing works
Twomey, J. D., George, S., & Zhang, B. (2025) · Antibody Therapeutics · doi:10.1093/abt/tbaf003 · Cited by 1 · see citing works
Way to go to exploit NK cells' versatile talents for cancer immunotherapy
Cho, D. (2014) · Blood Research · doi:10.5045/br.2014.49.3.139 · Cited by 1 · see citing works
Could Pharmacogenomics Improve Efficacy and Safety of Trastuzumab?
Yiannakopoulou, E. C. (2015) · Biochemistry & Pharmacology Open Access · doi:10.4172/2167-0501.1000e174 · Cited by 1 · see citing works
Chae, H., Yoo, C., Yoon, J.-A., Lee, H. J., Kim, K., Kim, J., Ahn, J., Jung, K. H., Gong, G., & Kim, S. (2018) · Journal of Breast Cancer · doi:10.4048/jbc.2018.21.1.45 · Cited by 1 · see citing works
Riller, Q., Varthaman, A., & Sibéril, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-50224-9_9 · Cited by 1 · see citing works
The Potential Predictors in Chemotherapy Sensitivity
Kim, E., & Shin, H.-C. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9620-6_19 · Cited by 1 · see citing works
Zheng, S., Wang, W., & Zhou, H. (2015) · Pharmaceutical Sciences Encyclopedia · doi:10.1002/9780470571224.pse545 · Cited by 1 · see citing works
- Authors
- Hurvitz, S. A., Betting, D. J., Stern, H. M., Quinaux, E., Stinson, J., Seshagiri, S., Zhao, Y., Buyse, M., Mackey, J., Driga, A., Damaraju, S., Sliwkowski, M. X., Robert, N. J., Valero, V., Crown, J., Falkson, C., Brufsky, A., Pienkowski, T., Eiermann, W., Martin, M., Bee, V., Marathe, O., Slamon, D. J., & Timmerman, J. M.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Authors' Affiliations: 1University of California at Los Angeles, Los Angeles; 2Genentech, South San Francisco, California; 3International Drug Development Institute, Louvain-la-Neuve, Belgium; 4Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; 5Virginia Cancer Specialists, US Oncology, Fairfax, Virginia; 6University of Texas MD Anderson Cancer Center, Houston, Texas; 7St. Vincent's Hospital, Dublin, Ireland; 8University of Alabama at Birmingham, Birmingham, Alabama; 9University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; 10Cancer Center, Warsaw, Poland; 11Redcross Women's Hospital, Muenchen, Germany; 12Hospital Gregorio Maranon, Madrid, Spain; and 13Breast Cancer International Research Group (BCIRG), Paris, France
- Corresponding author
- Hurvitz, Sara A.
- ORCID
- Venue
- Clinical Cancer Research
- Published
- 2012-06-14
- Volume
- 18
- Issue
- 12
- Pages
- 3478-3486
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- PMC
- PMC3821872
- OpenAlex
- W2162904392
- Cited by
- 115
- References
- 27
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 11 · 2016: 14 · 2015: 16 · 2014: 13 · 2013: 9 · 2012: 5
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1ul1rr033176-01, UL1TR000124)
- National Cancer Institute (P30CA016042)
- National Center for Research Resources (UL1-RR-033176)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Keywords
- FcγRIIIa, FCGR2A, single nucleotide polymorphisms, trastuzumab, HER2-positive breast cancer, disease-free survival, antibody-dependent cellular cytotoxicity, pharmacogenetics, adjuvant chemotherapy
- MeSH terms
- Trastuzumab, Adult, Aged, Breast Neoplasms, Female, Gene Frequency, Genotype, Humans, Middle Aged, Treatment Outcome, Receptors, IgG, Amino Acid Substitution, Polymorphism, Single Nucleotide, Young Adult, Antibodies, Monoclonal, Humanized
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