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Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate
Open accessPublished version of a preprint
Abstract
Purpose: Glutamine addiction in c-MYC–overexpressing breast cancer is targeted by the aminotransferase inhibitor, aminooxyacetate (AOA). However, the mechanism of ensuing cell death remains unresolved. Experimental Design: A correlation between glutamine dependence for growth and c-MYC expression was studied in breast cancer cell lines. The cytotoxic effects of AOA, its correlation with high c-MYC expression, and effects on enzymes in the glutaminolytic pathway were investigated. AOA-induced cell death was assessed by measuring changes in metabolite levels by magnetic resonance spectroscopy (MRS), the effects of amino acid depletion on nucleotide synthesis by cell-cycle and bromodeoxyuridine (BrdUrd) uptake analysis, and activation of the endoplasmic reticulum (ER) stress–mediated pathway. Antitumor effects of AOA with or without common chemotherapies were determined in breast cancer xenografts in immunodeficient mice and in a transgenic MMTV-rTtA-TetO-myc mouse mammary tumor model. Results: We established a direct correlation between c-MYC overexpression, suppression of glutaminolysis, and AOA sensitivity in most breast cancer cells. MRS, cell-cycle analysis, and BrdUrd uptake measurements indicated depletion of aspartic acid and alanine leading to cell-cycle arrest at S-phase by AOA. Activation of components of the ER stress–mediated pathway, initiated through GRP78, led to apoptotic cell death. AOA inhibited growth of SUM159, SUM149, and MCF-7 xenografts and c-myc–overexpressing transgenic mouse mammary tumors. In MDA-MB-231, AOA was effective only in combination with chemotherapy. Conclusions: AOA mediates its cytotoxic effects largely through the stress response pathway. The preclinical data of AOA's effectiveness provide a strong rationale for further clinical development, particularly for c-MYC–overexpressing breast cancers. Clin Cancer Res; 21(14); 3263–73. ©2015 AACR.
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“Glutamate consumption by aminotransferases to generate NEAAs has also been indicated to be required for tumor growth in diverse cancer types29,40–42.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [41]
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Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Mediators of endoplasmic reticulum stress-induced apoptosis
Szegezdi, E., Logue, S. E., Gorman, A. M., & Samali, A. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400779 · Cited by 2,345
Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124
Self-citationWise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683
Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
Jordheim, L. P., Durantel, D., Zoulim, F., & Dumontet, C. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4010 · Cited by 1,217
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature · doi:10.1038/nature11743 · Cited by 1,007
Cited by
Sorted by citations
Items 101–187 of 187
Delgir, S., Ilkhani, K., Safi, A., Rahmati, Y., Montazari, V., Zaynali-Khasraghi, Z., Seif, F., Bastami, M., & Alivand, M. R. (2021) · BMC Medical Genomics · doi:10.1186/s12920-021-01029-3 · Cited by 20
UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling
Sancerni, T., Renoult, O., Luby, A., Caradeuc, C., Lenoir, V., Croyal, M., Ransy, C., Aguilar, E., Postic, C., Bertho, G., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.960226 · Cited by 19
Yang, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.04.061 · Cited by 20
Elebo, N., Fru, P., Omoshoro–Jones, J., Candy, G. P., & Nweke, E. E. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11622 · Cited by 19
Yu, T., der Jeught, K. V., Zhu, H., Zhou, Z., Sharma, S., Liu, S., Eyvani, H., So, K. M., Singh, N., Wang, J., et al. (2024) · Advanced Science · doi:10.1002/advs.202310308 · Cited by 20
Trilla‐Fuertes, L., Gámez‐Pozo, A., López‐Camacho, E., Prado-Vázquez, G., Zapater‐Moros, A., López‐Vacas, R., Arevalillo, J. M., Díaz‐Almirón, M., Navarro, H., Maı́n, P., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-06764-x · Cited by 17
Glutaminolysis: A Driver of Vascular and Cardiac Remodeling in Pulmonary Arterial Hypertension
Mprah, R., Adzika, G. K., Gyasi, Y. I., Noah, M. L. N., Adu‐Amankwaah, J., Adekunle, A. O., Duah, M., Wowui, P. I., & Qiao, W. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.667446 · Cited by 17
Blood Plasma Metabolome Profiling at Different Stages of Renal Cell Carcinoma
Maslov, D. L., Trifonova, O. P., Lichtenberg, S., Balashova, E. E., Mamedli, Z. Z., Alferov, A. A., Stilidi, I. S., Lokhov, P. G., Кушлинский, Н. Е., & Archakov, A. I. (2022) · Cancers · doi:10.3390/cancers15010140 · Cited by 17
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
Southwell, N., Primiano, G., Nadkarni, V., Attarwala, N., Beattie, E., Miller, D., Alam, S., Liparulo, I., Shurubor, Y. I., Valentino, M. L., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216951 · Cited by 16
Ripoll, C., Roldán, M., Ruedas-Rama, M. J., Orte, Á., & Martı́n, M. (2021) · Biology · doi:10.3390/biology10121267 · Cited by 16
Metabolic interventions: A new insight into the cancer immunotherapy
Yu, T., Dong, T., Eyvani, H., Fang, Y., Wang, X., Zhang, X., & Lu, X. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108659 · Cited by 16
Aspartate in tumor microenvironment and beyond: Metabolic interactions and therapeutic perspectives
Soon, J. W., Manca, M. A., Laskowska, A., Starková, J., Rohlenová, K., & Rohlena, J. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167451 · Cited by 15
Targeting “undruggable” c-Myc protein by synthetic lethality
Wang, C., Fang, H., Zhang, J., & Gu, Y. (2021) · Frontiers of Medicine · doi:10.1007/s11684-020-0780-y · Cited by 13
Vacek, L., Dvořák, A., Bechyňská, K., Kosek, V., Elkalaf, M., Trinh, M. D., Fišerová, I., Pospíšilová, K., Slovakova, L., Vı́tek, L., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.663625 · Cited by 12
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
Houshmand, M., Vitale, N., Orso, F., Cignetti, A., Molineris, I., Gaidano, V., Sainas, S., Giorgis, M., Boschi, D., Fava, C., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05028-9 · Cited by 12
Targeting cellular adaptive responses to glutaminolysis perturbation for cancer therapy
Kim, M., Hwang, S., & Jeong, S. M. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100096 · Cited by 12
Cutruzzolà, F., Bouzidi, A., Liberati, F. R., Spizzichino, S., Boumis, G., Macone, A., Rinaldo, S., Giardina, G., & Paone, A. (2021) · Cancers · doi:10.3390/cancers13122891 · Cited by 12
Systematic Review of the Use of Phytochemicals for Management of Pain in Cancer Therapy
Harrison, A. M., Heritier, F., Childs, B. G., Bostwick, J. M., & Dziadzko, M. A. (2015) · BioMed Research International · doi:10.1155/2015/506327 · Cited by 12
Zhao, P., Shen, Y., Li, M., Dan, H., Zhao, Z., & Zhang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.793499 · Cited by 11
Huang, Y., Lu, H., Liu, Y. Z., Wang, J., Xia, Q., Shi, X., Jin, Y., Liang, X., Wang, W., Ma, X., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-024-00359-z · Cited by 10
Low-mass-ion discriminant equation (LOME) for ovarian cancer screening
Lee, J. H., Yoo, B. C., Kim, Y. H., Ahn, S.-A., Yeo, S., Cho, J. Y., Kim, K., & Kim, S. C. (2016) · BioData Mining · doi:10.1186/s13040-016-0111-7 · Cited by 10
A critical appraisal of the role of metabolomics in breast cancer research and diagnostics
Gadwal, A., Panigrahi, P., Khokhar, M., Sharma, V., Setia, P., Vishnoi, J. R., Elhence, P. A., & Purohit, P. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.119836 · Cited by 9
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02647-2 · Cited by 8
Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells
Chen, T., Xu, Y., Yang, F., Pan, Y., Ji, N., Li, J., Zeng, X. Y., Chen, Q., Jiang, L., & Shen, Y. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111874 · Cited by 9
Emerging roles and regulatory mechanisms involved in glutamine metabolism
Ryu, K. W., Fung, T. S., & Thompson, C. B. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.04.008 · Cited by 9
Baguet, T., Verhoeven, J., Pauwelyn, G., Hu, J., Lambe, P., Lombaerde, S. D., Piron, S., Donche, S., Descamps, B., Goethals, I., et al. (2020) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2020.03.006 · Cited by 7
The Use of Patient-Derived Organoids in the Study of Molecular Metabolic Adaptation in Breast Cancer
Glibetić, N., Bowman, S., Skaggs, T., & Weichhaus, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910503 · Cited by 6
Vasco, V. R. L. (2023) · OBM Geriatrics · doi:10.21926/obm.geriatr.2302234 · Cited by 6
GOT2: a moonlighting enzyme at the crossroads of cancer metabolism and theranostics
Hu, J., Liu, Q., Ren, Q., He, W., Hou, J., Wang, X., & Shu, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1626914 · Cited by 5
Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma
Galvan, C., Flores, A., Cerrilos, V., Avila, I., Murphy, C., Zheng, W., Christofk, H. R., Christofk, H. R., & Lowry, W. E. (2024) · Science Advances · doi:10.1126/sciadv.adn2806 · Cited by 5
Lestari, I. A., Putra, I., Fatimah, N., Ujiantari, N. S. O., Putri, D. D. P., & Hermawan, A. (2024) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2024.25.5.1623 · Cited by 5
Xie, B., Li, J., Lou, Y., Chen, Q., Yang, Y., Zhang, R., Liu, Z., He, L., & Cheng, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113019 · Cited by 4
Wang, Y., Dong, Q., Yuan, M., Hu, J., Lin, P., Yan, Y., Yan, Y., & Wang, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113892 · Cited by 4
Imaging the uptake and metabolism of glutamine in prostate tumor models using CEST MRI
Hodo, Y., Tressler, C. M., Ghaemi, B., Thomas, R. L., Webster, A. S., Williams, K. N. B., Li, Y., Pomper, M. G., Dang, C. V., Bhujwalla, Z. M., et al. (2025) · npj Imaging · doi:10.1038/s44303-025-00100-3 · Cited by 4
Self-citationYang, B., Su, Y., Han, S., Chen, R., Sun, R., Rong, K., Long, F., Teng, H., Zhao, J., Liu, Q., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.980678 · Cited by 5
Diseases & Disorders | Therapies Targeting Glutamine Addiction in Cancer
Attarwala, N., Zhang, C., & Le, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00079-7 · Cited by 4
MYC amplification sensitizes TNBC to CHK1 inhibitors
Li, B., Liu, T., Zhao, M., Guo, D., Peng, W., Tao, Z., Hu, X., & Jin, J. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111709 · Cited by 3
Targeting CAF-specific metabolic pathways in breast cancer
Bediwi, A. K., Hjazi, A., Kedhem, M., Alkhathami, A. G., RenukaJyothi, S., Nayak, P. P., Pargaien, A. V., Singh, U., Hammady, F. J., & Salih, S. A. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04390-7 · Cited by 3
Metabolic Vulnerabilities as a Therapeutic Target in Breast Cancer
Guo, S., & Addison, C. (2026) · Current Oncology · doi:10.3390/curroncol33020129 · Cited by 4
Siwo, G., Singal, A. G., & Waljee, A. K. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1727389 · Cited by 3
Therapeutic Targeting of Glutamine Metabolism in Colorectal Cancer
Ratre, Y. K., Verma, H. K., Mehta, A., Soni, V. K., Sonkar, S. C., Shukla, D., Ekka, A., Prajapati, S. K., Mahilkar, S., & Vishvakarma, N. K. (2021) · Springer eBooks · doi:10.1007/978-3-030-64668-4_15 · Cited by 4
Recent Advances in Drug Development Targeting Cancer Metabolism
Sugandha, N., Mittal, L., Awasthi, A., & Asthana, S. (2020) · Springer eBooks · doi:10.1007/978-981-15-1991-8_8 · Cited by 2
Emerging roles of the chromatin remodeler MORC2 in cancer metabolism
Mohapatra, B., & Pakala, S. B. (2024) · Medical Oncology · doi:10.1007/s12032-024-02464-9 · Cited by 1
Su, M., Qin, H., Shen, J., An, H., & Cao, Y. (2025) · Journal of Cell Communication and Signaling · doi:10.1002/ccs3.70033 · Cited by 1
Li, M., Zhao, W., Bai, L., Yuan, S., Zhu, Y., Wang, H., & Deng, J. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c01654 · Cited by 1
Targeting the Glutaminolysis Pathway in Glaucoma-Associated Fibrosis
Kelly, Á., Irnaten, M., & O’Brien, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010012 · Cited by 1
Amălinei, C., Balan, R. A., & Lozneanu, L. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_233 · Cited by 1
Terapia nutricional en el enfermo oncológico en estado crítico
Villarreal, A. Q., & Rodríguez, C. N. (2016) · Acta Colombiana de Cuidado Intensivo · doi:10.1016/j.acci.2016.07.002 · Cited by 1
Cheng, S., & Cui, D. (2017) · Translational medicine research · doi:10.1007/978-94-024-0951-2_5
[Bite marks as evidence in violent incidents, rapes and murders. Report of 2 cases].
Stavrianos, C., & Hourdakis, K. (1989) · PubMed
Baguet, T., Verhoeven, J., Pauwelyn, G., Hu, J., Lambe, P., Lombaerde, S. D., Piron, S., Donche, S., Descamps, B., Goethals, I., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.14.948372
Computational metabolomics hints at the relevance of glutamine metabolism in breast cancerPreprint
Trilla‐Fuertes, L., Gámez‐Pozo, A., López‐Camacho, E., Prado-Vázquez, G., Zapater‐Moros, A., López‐Vacas, R., Arevalillo, J. M., Díaz‐Almirón, M., Navarro, H., Maı́n, P., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/370221
Zhou, Y.-J., Zhou, Y.-J., Yu, H., Yu, H., Cheng, S., Cheng, S., Ren, J., Ren, J., Ren, F., Ren, F., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-105979/v1
Petruk, A. O., Lytvak, O. O., & Khabrat, A. (2021) · Clinical and Preventive Medicine · doi:10.31612/2616-4868.3(17).2021.09
Gleeson, P. A. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738812025.793585380
Amălinei, C., Balan, R. A., & Lozneanu, L. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_233-1
Delgir, S., Ilkhani, K., Safi, A., Seif, F., Bastami, M., Alivand, M. R., & Bastami, M. (2020) · doi:10.21203/rs.3.rs-28926/v1
Delgir, S., Ilkhani, K., Safi, A., Seif, F., Bastami, M., Alivand, M. R., & Montazari, V. (2020) · doi:10.21203/rs.3.rs-28926/v2
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279378
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279375
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279351
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279354
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279381
Trilla‐Fuertes, L., Gámez‐Pozo, A., López‐Camacho, E., Prado-Vázquez, G., Zapater‐Moros, A., López-Vacas, R., Arevalillo, J. M., Díaz-Almirón, M., Navarro, H., Maı́n, P., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12134208
Trilla‐Fuertes, L., Gámez‐Pozo, A., López‐Camacho, E., Prado-Vázquez, G., Zapater‐Moros, A., López-Vacas, R., Arevalillo, J. M., Díaz-Almirón, M., Navarro, H., Maı́n, P., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12134217
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C.-Y., & Zhou, L. (2022) · Figshare · doi:10.6084/m9.figshare.20279360
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C.-Y., & Zhou, L. (2022) · Figshare · doi:10.6084/m9.figshare.20279372
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C.-Y., & Zhou, L. (2022) · Figshare · doi:10.6084/m9.figshare.20279363
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C.-Y., & Zhou, L. (2022) · Figshare · doi:10.6084/m9.figshare.20279369
Trilla‐Fuertes, L., Gámez‐Pozo, A., López‐Camacho, E., Prado-Vázquez, G., Zapater‐Moros, A., López-Vacas, R., Arevalillo, J. M., Díaz-Almirón, M., Navarro, H., Maı́n, P., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12134193
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C.-Y., & Zhou, L. (2022) · Figshare · doi:10.6084/m9.figshare.20279366
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C.-Y., & Zhou, L. (2022) · Figshare · doi:10.6084/m9.figshare.20279357
Trilla‐Fuertes, L., Gámez‐Pozo, A., López‐Camacho, E., Prado-Vázquez, G., Zapater‐Moros, A., López-Vacas, R., Arevalillo, J. M., Díaz-Almirón, M., Navarro, H., Maı́n, P., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12134202
Trilla‐Fuertes, L., Gámez‐Pozo, A., López‐Camacho, E., Prado-Vázquez, G., Zapater‐Moros, A., López-Vacas, R., Arevalillo, J. M., Díaz-Almirón, M., Navarro, H., Maı́n, P., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12134220
Trilla‐Fuertes, L., Gámez‐Pozo, A., López‐Camacho, E., Prado-Vázquez, G., Zapater‐Moros, A., López-Vacas, R., Arevalillo, J. M., Díaz-Almirón, M., Navarro, H., Maı́n, P., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12134226
Dietary depletion of glutamine is atheroprotectivePreprint
Salamon, A., Katra, P., Milosek, V. M., Tripathi, R., Raval, R., Shankman, L. S., Krinsky, A. L., Koo, N., Shamsuzzaman, S., Engelbertsen, D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.06.710174
Rôle du transporteur mitochondrial UCP2 dans la leucémie
Sancerni, T. (2019) · theses.fr (ABES) · doi:10.70675/c0f1a3a3z992az4717zb426z210e51dadf82
Biochemical characterization of mTORC1 regulation by glutamine metabolism
Bodineau, C. (2020) · theses.fr (ABES) · doi:10.70675/9d5aaabdz81bdz4118zb3edze237bdd8dee0
Tang, N., Gong, Y., Zhao, C., Niu, Y., Tan, L., Song, C., Qiu, X., Liao, Y., Yu, S., Ding, C., et al. (2026) · Tumour Virus Research · doi:10.1016/j.tvr.2026.200342
Bardelčíková, A., Smolková, K., Špačková, J., Gotvaldová, K., Gardlík, R., Kovalčíková, A. G., Kudlicková, Z., Kello, M., & Mojžíš, J. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112189
Role of molecular target therapies in effective breast cancer treatments
Ghosh, B., Shil, S., & Kumavath, R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-43846-2.00017-9
Dieterich, W., Pradhan, R., Suwandi, A., Korkmaz, R. Ü., Neurath, M. F., & Zopf, Y. (2026) · Nutrients · doi:10.3390/nu18132125
Peng, X., Liu, S., & Tao, Y. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00812-1
Kadyrova, A. S., Rizvanov, A. A., & Solovyeva, V. V. (2026) · Molecular Biology · doi:10.1134/s0026893326700159
Zhang, C., Yang, Y., Tian, W., Zhang, J., Ge, C., Meng, L., Liu, Y., Wei, Z., & Tian, H. (2026) · Science Advances · doi:10.1126/sciadv.aei7877
Metadata
- Authors
- Korangath, P., Teo, W. W., Sadik, H., Han, L., Mori, N., Huijts, C. M., Wildes, F., Bharti, S., Zhang, Z., Santa-Maria, C. A., Tsai, H., Dang, C. V., Stearns, V., Bhujwalla, Z. M., & Sukumar, S.
- Affiliations
- Johns Hopkins University (US)
- 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
- 1Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
- University of Pennsylvania (US)
- Corresponding author
- Sukumar, Saraswati
- ORCID
- Venue
- Clinical Cancer Research
- Published
- 2015-07-14
- Volume
- 21
- Issue
- 14
- Pages
- 3263-3273
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- PMC
- PMC4696069
- OpenAlex
- W2011628468
- Cited by
- 182
- References
- 40
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 18 · 2023: 7 · 2022: 30 · 2021: 15 · 2020: 28 · 2019: 13 · 2018: 13 · 2017: 17 · 2016: 15 · 2015: 3
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pennsylvania
- National Cancer Institute (R01CA051497, P30CA060553, P30CA006973, P30CA016520)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- aminooxyacetic acid, glutamine metabolism, glutaminolysis, MYC overexpression, breast cancer, endoplasmic reticulum stress, GRP78, apoptosis, S phase arrest, amino acid starvation, nucleotide synthesis, combination chemotherapy, xenografts
- MeSH terms
- Endoplasmic Reticulum Chaperone BiP, Aminooxyacetic Acid, Animals, Antineoplastic Agents, Breast Neoplasms, Enzyme Inhibitors, Female, Glutamine, Humans, Mice, Transgenic, Magnetic Resonance Spectroscopy, Xenograft Model Antitumor Assays, Cell Line, Tumor, Mice
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