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Cited by 517

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

Open access
Meyskens, Frank L., McLaren, Christine E., Pelot, Daniel, Fujikawa-Brooks, Sharon, Carpenter, Philip M., Hawk, Ernest, Kelloff, Gary, Lawson, Michael J., Kidao, Jayashri, McCracken, John, Albers, C. Gregory, Ahnen, Dennis J., Turgeon, D. Kim, Goldschmid, Steven, Lance, Peter, Hagedorn, Curt H., Gillen, Daniel L., Gerner, Eugene W.·2008·Cancer Prevention Research
DOI 10.1158/1940-6207.capr-08-0042
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Abstract

Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing adenomas with little additional toxicities, suggesting a strategy to improve risk to benefit ratios for preventing recurrent adenomas. Three hundred seventy-five patients with history of resected (≥3 mm) adenomas were randomly assigned to receive oral difluoromethylornithine (DFMO) 500 mg and sulindac 150 mg once daily or matched placebos for 36 months, stratified by use of low-dose aspirin (81 mg) at baseline and clinical site. Follow-up colonoscopy was done 3 years after randomization or off-study. Colorectal adenoma recurrence was compared among the groups with log-binomial regression. Comparing the outcome in patients receiving placebos to those receiving active intervention, (a) the recurrence of one or more adenomas was 41.1% and 12.3% (risk ratio, 0.30; 95% confidence interval, 0.18-0.49; P < 0.001); (b) 8.5% had one or more advanced adenomas, compared with 0.7% of patients (risk ratio, 0.085; 95% confidence interval, 0.011-0.65; P < 0.001); and (c) 17 (13.2%) patients had multiple adenomas (>1) at the final colonoscopy, compared with 1 (0.7%; risk ratio, 0.055; 0.0074-0.41; P < 0.001). Serious adverse events (grade ≥3) occurred in 8.2% of patients in the placebo group, compared with 11% in the active intervention group (P = 0.35). There was no significant difference in the proportion of patients reporting hearing changes from baseline. Recurrent adenomatous polyps can be markedly reduced by a combination of low oral doses of DFMO and sulindac and with few side effects.

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Registry

Crossref · 10.1158/1940-6207.capr-08-0042

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Metadata

Authors
Meyskens, F. L., McLaren, C. E., Pelot, D., Fujikawa-Brooks, S., Carpenter, P. M., Hawk, E., Kelloff, G., Lawson, M. J., Kidao, J., McCracken, J., Albers, C. G., Ahnen, D. J., Turgeon, D. K., Goldschmid, S., Lance, P., Hagedorn, C. H., Gillen, D. L., & Gerner, E. W.
Venue
Cancer Prevention Research
Publisher
American Association for Cancer Research (AACR)
Published
2008-06-01
Volume
1
Issue
1
Pages
32-38
ISSN
  • 1940-6207 (ISSN-L)
  • 1940-6215
DOI
10.1158/1940-6207.capr-08-0042
OpenAlex
W2097235831
Cited by
517
References
31
FWCI
25.41
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial. https://app.cochat.ai/papers/10.1158/1940-6207.capr-08-0042
The paper
Meyskens, F. L., McLaren, C. E., Pelot, D., Fujikawa-Brooks, S., Carpenter, P. M., Hawk, E., Kelloff, G., Lawson, M. J., Kidao, J., McCracken, J., Albers, C. G., Ahnen, D. J., Turgeon, D. K., Goldschmid, S., Lance, P., Hagedorn, C. H., Gillen, D. L., & Gerner, E. W. (2008). Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial. Cancer Prevention Research. https://doi.org/10.1158/1940-6207.capr-08-0042

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.