Toxic phytochemicals and their potential risks for human cancer
Open accessAbstract
Consuming plants for their presumed health benefits has occurred since early civilizations. Phytochemicals are found in various plants that are frequently included in the human diet and are generally thought to be safe for consumption because they are produced naturally. However, this is not always the case and in fact many natural compounds found in several commonly consumed plants are potential carcinogens or tumor promoters and should be avoided.
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High doses of pure compounds have been linked to carcinogenesis.
“and even carcinogenesis [236]”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [236]
The in vivo safety of high doses of pure compounds (over 100 times higher than the natural occurrence in some cases) is unlikely to be feasibly extrapolated from in vitro mechanistic research.
“Furthermore, the in vivo safety of high doses of pure compounds (over 100 times higher than the natural occurrence in some cases) is unlikely to be feasibly extrapolated from in vitro mechanistic research, with several studies reporting the increased risk of hepatotoxicity [234], and others highlighting the increased risk of stroke and premature death [235], and even carcinogenesis [236].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [236]
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References 120 · Cited by 140
Research works printed but not linked: 1
- [94]Radominska-Pandya A Preface Drug Metab Rev 2010 42 1 2 20070243
- Authors
- Bode, A. M., & Dong, Z.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Dong, Zigang
- Venue
- Cancer Prevention Research
- Published
- 2015-01-01
- Volume
- 8
- Issue
- 1
- Pages
- 1-8
- ISSN
- 1940-6207 (ISSN-L)
- 1940-6215
- PMC
- PMC4289646
- OpenAlex
- W2133630830
- Cited by
- 140
- References
- 120
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 19 · 2023: 17 · 2022: 21 · 2021: 21 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 2
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Prevention Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 120388, R01CA111536, CA 077646, R01CA120388, R01CA077646, R37CA081064, CA111536)
- National Institute of Environmental Health Sciences (ES016548, R01ES016548)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Toxicity and Pharmacological Properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- tumor promoters, dietary cancer risk, food safety, natural compounds, cancer prevention
- MeSH terms
- Amygdalin, Capsaicin, Cycasin, Diet, Drug Screening Assays, Antitumor, Humans, Indans, Phytotherapy, Neoplasms, Phorbol Esters, Plant Extracts, Plants, Pyrrolizidine Alkaloids, Safrole, Sesquiterpenes, Aristolochic Acids, Cell Line, Tumor, Phytoestrogens, Phytochemicals
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