An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Guo, Deliang, Reinitz, Felicia, Youssef, Mary, Hong, Cynthia, Nathanson, David, Akhavan, David, Kuga, Daisuke, Amzajerdi, Ali Nael +22 more·2011·Cancer Discovery

Cited by (451)

Items 301–400 of 451

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    Alina M. Winkelkotte, Kamal M. Al-Shami, Adriano B. Chaves‐Filho, Felix C. E. Vogel, Almut Schulze · 2024 · Cold Spring Harbor Perspectives in Medicine
  3. Involvement of Intracellular Cholesterol in Temozolomide-Induced Glioblastoma Cell Death
    Y. Lucas Yamamoto, Nobuyoshi Sasaki, Kosuke Kumagai, Satoru Takeuchi, Terushige Toyooka, Naoki Otani, Kojiro Wada, Yoshitaka Narita, Koichi Ichimura, Hiroki Namba et al. · 2018 · Neurologia medico-chirurgica
  4. Oroxin A from Oroxylum indicum improves disordered lipid metabolism by inhibiting SREBPs in oleic acid-induced HepG2 cells and high-fat diet-fed non-insulin-resistant rats
    Tianqi Cai, Xiaoxue Xu, Ling Dong, Shufei Liang, Meiling Xin, Tianqi Wang, Tianxing Li, Xudong Wang, Weilong Zheng, Chao Wang et al. · 2024 · Heliyon
  5. Metabolism: an important player in glioma survival and development
    Ning Wang, Yiru Yuan, Tianhao Hu, Huizhe Xu, Haozhe Piao · 2024 · Discover Oncology
  6. Tumor-infiltrating and circulating B cells mediate local and systemic immunomodulatory mechanisms in Glioblastoma
    Pierfrancesco De Domenico, Filippo Gagliardi, Francesca Roncelli, Silvia Snider, Pietro Mortini · 2025 · Journal of Neuro-Oncology
  7. Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma
    Verónica Freire-Benéitez, Nicola Pomella, Thomas O Millner, Anaëlle A Dumas, Maria Victoria Niklison-Chirou, Eleni Maniati, Jun Wang, Vinothini Rajeeve, Pedro R. Cutillas, Silvia Marino · 2021 · NAR Cancer
  8. RNA mutations in the moth pheromone gland
    Peng Ru, Deliang Guo · 2014 · RNA & DISEASE
  9. LXR Inhibits Proliferation of Human Breast Cancer Cells through the PI3K-Akt Pathway
    Treska S. Hassan, Aida Paniccia, Vincenzo E. A. Russo, Knut Rune Steffensen · 2015 · Nuclear Receptor Research
  10. Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells
    Leonardo Gatticchi, Bruno Cerra, Paolo Tommaso Scarpelli · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  11. Phospholipase Cε Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway
    Yongbo Zheng, Jiajia Jin, Yingying Gao · 2020 · Medical Science Monitor
  12. Transcriptomic Analysis Unveils Correlations between Regulative Apoptotic Caspases and Genes of Cholesterol Homeostasis in Human Brain
    Raffaella Picco, Andrea Tomasella, Federico Fogolari, Claudio Brancolini · 2014 · PLoS ONE
  13. Tumor Metabolism: A New Field for the Treatment of Glioma
    Xiaoqian Chai, Yingjie Zhang, Wen Zhang, Kuanhan Feng, Yingyu Jiang, Anran Zhu, Xiaojin Chen, Liuqing Di, Ruoning Wang · 2024 · Bioconjugate Chemistry
  14. Metabolic adaptation of myeloid cells in the glioblastoma microenvironment
    Nora Essakhi, Alexandre Bertucci, Nathalie Baeza, Carole Colin, Rosario Lavignolle, Paulina A García-González, Rafael José Argüello, Aurélie Tchoghandjian, Émeline Tabouret · 2024 · Frontiers in Immunology
  15. Targeting cholesterol metabolism: a promising therapy strategy for cancer
    Chun-Lan Dai, Zi-yang Qiu, Anqi Wang, Yan Hong Shen, Lijun Zhang, Xin Luan · 2025 · Acta Pharmacologica Sinica
  16. Combined therapeutic potential of nuclear receptors with receptor tyrosine kinase inhibitors in lung cancer
    Peninah M. Wairagu, Kwang Hwa Park, Jihye Kim, Jong-Whan Choi, Hyun-Won Kim, Byung‐Il Yeh, Soon‐Hee Jung, Suk‐Joong Yong, Yangsik Jeong · 2014 · Biochemical and Biophysical Research Communications
  17. Altered gene expression in glycolysis–cholesterol synthesis axis correlates with outcome of triple-negative breast cancer
    Pengcheng Zhong, Rong Shu, Huiwen Wu, Zhiwen Liu, Xiaoling Shen, Yingjie Hu · 2020 · Experimental Biology and Medicine
  18. SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma
    Chuandong Cheng, Junhong Tu, Zengchun Hu · 2022 · Pathology - Research and Practice
  19. The Aurora Kinase Inhibitor TAK901 Inhibits Glioblastoma Growth by Blocking SREBP1-Mediated Lipid Metabolism
    Xiudan Zhan, Ru Qiu, Yi He · 2022 · Cancers
  20. Recent advances in understanding brain cancer metabolomics: a review
    Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Raja Ganesan, Kaviyarasi Renu, Balachandar Vellingiri, Abhijit Dey, Mohamudha Parveen Rahamathulla · 2023 · Medical Oncology
  21. LXRα‐mediated downregulation of EGFR suppress colorectal cancer cell proliferation
    Xiaolong Liang, Yi Lin Cao, Song Xiang · 2019 · Journal of Cellular Biochemistry
  22. Transcriptomic Analysis of Glioma Based on IDH Status Identifies ACAA2 as a Prognostic Factor in Lower Grade Glioma
    Chenxing Wu, Hongwang Song, Xiaojun Fu, Shouwei Li, Tao Jiang · 2020 · BioMed Research International
  23. Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development
    Saketh Sriram Dinavahi, Yu‐Chi Chen, Raghavendra Gowda et al. · 2022 · International Journal of Molecular Sciences
  24. The multifaceted therapeutical role of low‐density lipoprotein receptor family in high‐grade glioma
    Elisa Mastrantuono, Matilde Ghibaudi, Diana Matias, Giuseppe Battaglia · 2024 · Molecular Oncology
  25. Lipidomics-driven drug discovery and delivery strategies in glioblastoma
    Xiaohui Weng, Michael Gonzalez, Jeannes Angelia, Somayeh Piroozmand, Saleh Jamehdor, Amir Barzegar Behrooz, Hamid Latifi‐Navid, Mazaher Ahmadi, Stevan Pecic · 2024 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  26. Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth
    Huali Su, Yaogang Zhong, Liqing He, Feng Geng, Xinmin Yin, Yongjun Kou, Chengyao Chiang, Xiaokui Molly Mo, Yunzhou Fan, Yanwei Liu et al. · 2025 · Science Advances
  27. Lipids: Driving Forces in the Underlying Biology of Carcinogenesis
    Sohini Chakraborty, Anudarshini Sathish Kumar, Satarupa Banerjee · 2025 · ACS Pharmacology & Translational Science
  28. Anlotinib affects systemic lipid metabolism and induces lipid accumulation in human lung cancer cells
    Zhongling Zhu, Shan Xu, Jing Ren · 2023 · Lipids in Health and Disease
  29. Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers
    Mohamed Ksila, Imen Ghzaiel, Khouloud Sassi, Amira Zarrouk, Valerio Leoni, Giuseppe Poli, Leila Rezig, Vivien Pires, Smail Meziane, Atanas G. Atanasov et al. · 2023 · Advances in experimental medicine and biology
  30. Hydrogen sulfide accumulates LDL receptor precursor via downregulating PCSK9 in HepG2 cells
    Yong Chun Huang, Ke Ning, Wenwen Li · 2020 · American Journal of Physiology-Cell Physiology
  31. Repurposing Clemastine to Target Glioblastoma Cell Stemness
    Michael A. Sun, Rui Ryan Yang, Heng Liu, Wenzhe Wang, Xiao Song, Bo Hu, Nathan Reynolds, Kristen Roso, Lee H. Chen, Paula K. Greer et al. · 2023 · Cancers
  32. Suppressing PD-L1 Expression via AURKA Kinase Inhibition Enhances Natural Killer Cell-Mediated Cytotoxicity against Glioblastoma
    Trang Thi Thu Nguyen, Qiuqiang Gao, Jeong-Yeon Mun, Zhe Zhu, Chang Shu, Aaron Naim, Meri Rogava, Benjamin Izar, Mike‐Andrew Westhoff, Georg Karpel‐Massler et al. · 2024 · Cells
  33. Cholesterol: The driving force behind the remodeling of tumor microenvironment in colorectal cancer
    Ke Wang, Yuanyuan Zhang, Chengshuai Si, Yuepeng Cao, Peng Shao, Pei Zhang, Nannan Wang, Guoqing Su, Jinghang Qian, Yang Liu · 2024 · Heliyon
  34. Research progress of epidermal growth factor receptor in metabolic dysfunction‐associated steatotic liver disease and related diseases
    Ziwen Wang, Ze Jin, Zhi-fan Xiong · 2025 · Diabetes Obesity and Metabolism
  35. SREBP1a induced PINK1-Parkin mediated mitophagy facilitates ovarian cancer progression
    S. K. Eashayan Tanbir, Sib Sankar Roy · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  36. Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma
    Xu Zhang, Rongrong Gao, Liuke Yang, Youwei Zhu, Tiancheng Zhang, Xiaorong Shen, Wenwen Gu, Long Yang, Shenjie Peng · 2024 · Clinical and Translational Discovery
  37. Transcriptional Analysis of Aggressiveness and Heterogeneity across Grades of Astrocytomas
    Chunjing Wang, Cory C. Funk, James A. Eddy, Nathan D. Price · 2013 · PLoS ONE
  38. ATF4/TXNIP/REDD1/mTOR signaling mediates the antitumor activities of liver X receptor in pancreatic cancers
    Zhikang Chen, Xiaobo Lai, Hui Ding, Aijun Zhang, Yufei Sun, Jianhua Ling, Paul J. Chiao, Zihua Chen, Xuefeng Xia · 2022 · Cancer Innovation
  39. L-methionine promotes CD8+ T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling
    Chengsha Yuan, Chang-Peng Hu, Hu-Yue Zhou, Wuyi Liu, Wen-jing Lai, Ya-Feng Liu, Yue Yin, Guo-Bing Li, Rong Zhang · 2025 · Neoplasia
  40. Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism
    James Wood, Salah Abdelrazig, Sergey Evseev, Catherine A. Ortori, Marcos Castellanos‐Uribe, Sean Tobias May, David A. Barrett, Mohammed Diksin, Sajib Chakraborty, Dong‐Hyun Kim et al. · 2022 · Cancers
  41. Therapeutic protein PAK restrains the progression of triple negative breast cancer through degrading SREBP-1 mRNA
    Pan Hu, Peiyi Zhou, Tieyun Sun · 2023 · Breast Cancer Research
  42. Targeting NPC1 in Renal Cell Carcinoma
    Rushaniya Fazliyeva, Peter B. Makhov, Robert G. Uzzo, Vladimir M. Kolenko · 2024 · Cancers
  43. NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells
    Yuhki Saito, Yanhong Yang, Misa Saito, Christopher Y. Park, Kosuke Funato, Viviane S. Tabar, Robert B. Darnell · 2024 · Proceedings of the National Academy of Sciences
  44. Integrating lipidomics, 16S rRNA sequencing, and network pharmacology to explore the mechanism of Qikui granule in treating diabetic kidney disease mice
    Qing You, Lin Yang, Jiahui Gong · 2024 · Journal of Chromatography B
  45. Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer
    Doaa S. R. Khafaga, Ghazala Muteeb, Darin W Aswa, Mohammad Aatif, Mohd Farhan, Salma Allam · 2025 · SLAS DISCOVERY
  46. Comprehensive Analysis of a Novel Lipid Metabolism-Related Gene Signature for Predicting the Prognosis and Immune Landscape in Uterine Corpus Endometrial Carcinoma
    Xiaofang Tan, Shuang Liu, Liangyu Yao, Guoliang Cui, Jinhui Liu, Jiayi Ding · 2022 · Journal of Oncology
  47. Fasudil Increased the Sensitivity to Gefitinib in NSCLC by Decreasing Intracellular Lipid Accumulation
    Tingting Liao, Jingjing Deng, Wenjuan Chen et al. · 2022 · Cancers
  48. A systematic review of antipsychotic drug effects on human gene expression related to risk factors for cardiovascular disease
    Debra L. Foley, Andrew James Mackinnon · 2014 · The Pharmacogenomics Journal
  49. A Novel Liver X Receptor Inverse Agonist Impairs Cholesterol and Phospholipid Metabolism and Induces Apoptosis and Necroptosis in Pancreatic Ductal Adenocarcinoma Cells
    Scott Widmann, Shivangi Srivastava, Chin‐Yo Lin · 2023 · Receptors
  50. Comprehensive analysis reveals cholesterol metabolism-related signature for predicting prognosis and guiding individualized treatment of glioma
    Dengfeng Lu, Fei Wang, Yayi Yang · 2025 · Heliyon
  51. The roles of ATP‐binding cassette transporter A1 and its substrate cholesterol in head and neck cancers
    Fatma Şanli, Ömer Faruk Karataş · 2023 · Cell Biology International
  52. Menin Maintains Cholesterol Content in Colorectal Cancer via Repression of LXR-Mediated Transcription
    Thomas E. Nyul, Keely A. Beyries, Taylor Hojnacki et al. · 2023 · Cancers
  53. Advances in the study of antisense long‑stranded non‑coding RNAs in tumors (Review)
    Yifan Shao, Yuwei Dong, Jing Zhou, Zhihua Lü, Chen Chen, Xiaomin Yuan, Linhai He, Wenwen Tang, Zepeng Chen, Yuji Wang et al. · 2024 · International Journal of Oncology
  54. Mitochondrial lipid metabolism in metastatic breast cancer
    Bhuban Ruidas · 2024 · Mitochondrial Communications
  55. SREBP-1 increases glucose uptake to promote tumor resistance to lysosome inhibition
    Yaogang Zhong, Feng Geng, Huali Su, Logan Mazik, Xinmin Yin, Meixia Pan, Na Li, C. W. Chiang, Jeffrey R. Tonniges, Xiaokui Molly Mo et al. · 2026 · Science Translational Medicine
  56. Predictors of early colorectal cancer metastasis to lymph nodes: providing rationale for therapy decisions
    Song Xu, Jun Li, Jiang Zhu, Yun-Fei Kong, Yuhang Zhou, Zi-Kun Wang, Jin Zhang · 2024 · Frontiers in Oncology
  57. HDL Nanodiscs Loaded with Liver X Receptor Agonist Decreases Tumor Burden and Mediates Long‐term Survival in Mouse Glioma Model
    Troy A. Halseth, Anzar Mujeeb, Lisha Liu, Kaushik Banerjee, Nigel Lang, Todd Charles Hollon, Minzhi Yu, Mark Vander Roest, Ling Mei, Hongliang He et al. · 2025 · Small
  58. The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches
    Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis · 2025 · Medicinal Research Reviews
  59. Modified lipidomic profile of cancer-associated small extracellular vesicles facilitates tumorigenic behaviours and contributes to disease progression
    Jordan Fyfe, Pratibha Malhotra, Marco Falasca · 2022 · Advances in Biological Regulation
  60. Advances in synthetic lethality modalities for glioblastoma multiforme
    Seidu A. Richard · 2024 · Open Medicine
  61. Lipoproteins and Cancer
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  62. Hippo pathway effectors are associated with glioma patient survival, control cell proliferation and sterol metabolism through TEAD3
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  63. Targeting cholesterol metabolism in tumor and its immune microenvironment: opportunities and challenges
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  64. Quercetin’s regulation of glucose and lipid metabolism in gestational diabetes mellitus: role of the PCSK9/LDLR axis
    Letong Hong, Shuting Xia, Niankun Chen, Zilian Wang, Zhuyu Li · 2025 · Nutrition & Metabolism
  65. Targeting Metabolic Vulnerabilities in Glioblastoma: a Framework for Multi-node Combination Therapy
    Vishal Gokani, Anuhya Kotta, Venkata Repaka, Sukanya Rauniyar, Evan Noch · 2026 · Current Oncology Reports
  66. Deciphering the topological landscape of glioma using a network theory framework
    Meng-Chao Yao, Yang Su, Ruiqi Xiong, Xile Zhang, Xiaomei Zhu, Yong-Cong Chen, Ping Ao · 2024 · Scientific Reports
  67. EGFR inhibitor suppresses tumor growth by blocking lipid uptake and cholesterol synthesis in non-small cell lung cancer
    Byung‐Ho Rhie, Sang Hyeon Woo, Hyun‐Yi Kim et al. · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  68. Cancer Stem Cells in Glioblastoma: The Role of the mTOR Pathway
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  69. Cholesterol metabolism and tumor radiotherapy
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  70. Cancer RNome: Evolution and Sustenance
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  71. Fructose, Another Sweet for Cancer: A Context Acting Nutrient Hypothesis
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  72. Dynamic extracellular proximal interaction profiling reveals Low-Density Lipoprotein Receptor as a new Epidermal Growth Factor signaling pathway component
    Rasha Al Mismar, Payman Samavarchi‐Tehrani, Brendon Seale · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Targeting Liver X Receptors in Cancer Drug Discovery
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  74. Aging-associated mechanisms and metabolic vulnerabilities in esophageal carcinoma: an integrative review
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  75. Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity
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  76. Enhanced delivery of low-density lipoprotein-based nanoparticles to the mouse glioblastoma using focused ultrasound as a novel therapy
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  77. Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway
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  79. Highlights from the Literature
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  80. 4-Acetylantrocamol LT3 Inhibits Glioblastoma Cell Growth and Downregulates DNA Repair Enzyme O6-Methylguanine-DNA Methyltransferase
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  81. The Effects of Sterol-Related Signaling Pathways on Glioma
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  85. Correction: An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway
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  86. Identification and validation of cholesterol metabolism-related gene GNB3 as prognosis biomarker for pancreatic adenocarcinoma
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  98. ZBTB18 inhibits SREBP-dependent fatty acid synthesis by counteracting CTBPs and KDM1A/LSD1 activity in glioblastoma
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  99. Cholesterol Analogs Ginsenosides Rg1 and Compound K Control Temozolomide Resistance in Glioblastoma Cells by Regulating Cholesterol Efflux and Lipid Raft Distribution
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  100. Energy Landscape near Glioma Decipher the Role of Glioma Stem Cells within Glioma Hierarchy
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